Position:
Associate Professor
Division:
Hematology
Research Interests:

Cancer associated thrombosis, epidemiology, prevention, diagnosis, management

Education:
Doctor of Medicine University of British Columbia, Vancouver, BC
Master of Science McMaster University, Hamilton, ON Clinical Health Sciences, Health Research Methodology
Recent Publications:
  • Carrier M, Le Gal G, Tay J, Wu C. Lee AY.  Rates of Venous Thromboembolism in Multiple Myeloma Patients Undergoing Immunomodulatory Therapy with Thalidomide and Lenalidomide: A Systematic Review and Meta-Analysis. J Thrombo Haemost 2011 (in press).
  • Lee AYY. Evidence-Based Treatment of Cancer-Associated Thrombosis.  Canadian Journal of General Internal Medicine 2011 (in press).
  • Saber W, Moua T, Willimas EC, Verso M, Agnelli G, Couban S, Young A, De Cicco M, Biffi R, van Rooden CJ, Husiman MV, Fagnani D, Cimminiello A, Magagnoli M, Povoski SP, Malak S, Lee A.  Independent risk factors of catheter-related thrombosis (CRT) in adult cancer patients: an individual patient-level data (IPD) meta-analysis of randomized clinical trials and prospective cohort studies. J Thromb Haemost 2011;9:312-9.
  • Chan WS, Lee A, Spencer F, Chunilal S, Crowther M, Au M, Johnston M, Rodger M, Ginsberg JS.  D-dimer testing in pregnant patients: towards determining the next level in the diagnosis of DVT. J Thromb Haemost 2010;8(5):1004-1011.
  • Lee AY.  Diagnosis and treatment of cancer-related thrombosis.  Haematologica 2010 (in press).
  • Lee AY.  The roles of anticoagulants in patients with cancer.  Thromb Res 2010 (in press).
  • Lee AY. En route to personalized prophylaxis. Blood 2010;116(24):5085-6.
  • Wu C, Lee AY.  Malignancy and thrombosis in the critical care patient.  Critical Care Med 2010;38 (2):S64-S70.
  • Carrier M, Le Gal G, Cho R, Tierney A, Rodger M, Lee AY. Dose escalation of low molecular weight heparin to manage recurrent venous thromboembolic events despite systemic anticoagulation in cancer patients. J Thromb Haemost 2009;7:760-765.
  • Cook D, Sinuff  T, Zytaruk N, Rabbat C, Lee A, O’Donnell M, Thabane L, Linkins L, Treleaven D, Patel R, Meade M, Crowther M, Marshall J, Douketis J. Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis J Crit Care 2009;24:168-175.
  • Fitchett D, Eikelboom J, Fremes S, Mazer D, Singh S, Bittira B, Brister s, Graham J, Gupta M, Karkouti K, Lee AY, Love M, McArthur R, Peterson M Verma S, Yau T. Dual Antiplatelet therapy in patients requiring urgent coronary artery bypass grafting surgery: A position statement of the Canadian Cardiovascular Society. Can J Cardiol 2009;25(12): 683-689.
  • Lee AY.  Treatment of venous thromboembolism in cancer patients.  BestPract Res Clin Haematol 2009;22(1):93-101.
  • Lee AY. Anticoagulation in the treatment of established venous thromboembolism in patients with cancer.  J Clin Oncol 2009;27(29):4895-4901.
  • Lyman GH, Khorana AA, Kuderer NM, Lee AY. Cancer and Thrombosis: Back to the Future Renewed Interest in an Old Problem. Cancer Investigation 2009;27:472-473.
  • Scully M, Lee AY. The Challenge of Cancer and Thromboembolic Disease: Current trends and recommendations.  Oncology Exchange 2009;8(3): 6-10.
  • Brose K, Lee AYY.  Cancer-associated thrombosis: prevention and treatment. Curr Oncol 2008;15 Suppl 1:S58-S67.
  • Carrier M, Lee AYY, Bates SM, Anderson DR, Wells PS.  Accuracy and usefulness of a clinical prediction rule and D-dimer testing in excluding deep vein thrombosis in cancer patients.  Thromb Res 2008;123:177-183.
  • Carrier M, Lee AYY.  Prophylactic and therapeutic anticoagulation for thrombosis: major issues in oncology. Nat Clin Prac Oncol 2008;6(2):74-84.
  • Kavsak P, Lee A, Hirte A, Young E, Gauldie J.  Cytokine elevations in acute coronary syndrome and ovarian cancer: a mechanism for the up-regulation of the acute phase proteins in these different disease etiologies. Clin Biochem 2008;41:7-8:607-610.
  • Lee AYY.  Cancer and venous thromboembolism: prevention, treatment and survival.  J Thromb Thrombolysis 2008;25:33-36.
  • Lee AYY.  VTE in patients with cancer – diagnosis, prevention and treatment.  Thromb Res 2008;123 Suppl 1:S50-S54.
  • Zacharski L, Lee AYY. Heparin as an anticancer therapeutic. Expert Opinions on Investigation Drugs 2008;17(7):1029-1037.
  • Chan W-S, Chunilal S, Lee A, Crowther M, Rodger M, Ginsberg JS.  A red cell agglutination D-dimer test for the exclusion of deep venous thrombosis in pregnancy: a prospective cohort study. Ann Intern Med 2007;147:165-170.
  • Lee AYY.  Prevention of Deep Vein Thrombosis in Cancer Patients.  Semin Thromb Haemost 2007;33(7):699–706.
  • Lee AYY. The effects of low molecular weight heparins on venous thromboembolism and survival in patients with cancer.  Thromb Res 2007;120(Suppl 2):S121-127.
  • Andreou EA, Lee AYY.  Prevention of venous thromboembolism in patients with cancer. New Oncology: Thrombosis 2006;1(2):18-23.
  • Kearon C, Ginsberg J, Douketis J, Turpie AGG, Bates SM, Lee AY, Crowther MA, Weitz JI, Brill-Edwards P, Wells P, Anderson DR, Kovacs MJ, Linkins LA, Julian JA, Bonilla LR, Gent M for the Canadian Pulmonary Embolism Diagnosis Study (CANPEDS) Group. An evaluation of D-dimer in the diagnosis of pulmonary embolism: randomized trial.  Ann Intern Med 2006;144(11):812-21.
  • Lee AY.  The role of low-molecular-weight heparins in treating thrombosis.  J Support Oncol 2006;4(3):123-4.
  • Lee AY.  Treatment of cancer-associated thrombosis.  Vnitr Lek 2006;52 Suppl 1:127-8, 130-1.
  • Lee AYY, Levine MN, Butler G, Webb C, Costantini L, Chushu G, Julian JA. Incidence, risk factors and outcomes of catheter-related thrombosis in adult patients with cancer. J Clin Oncol 2006;24(9):1404-8.
  • Lee AYY.  Dalteparin sodium in the management of thromboembolic disorders.  Therapy 2006; 3(4):461-474.