Position:
Associate Professor
Division:
Critical Care Medicine
Research Interests:

Airways inflammatory diseases, apoptosis, ischemia/reperfusion

Education:
McGill University, Biochemistry, BSc,
McGill University, MD
McGill University, PhD
Recent Publications:

•Allahverdian S, Patchell BJ and Dorscheid DR. Carbohydrates and epithelial repair – more than just post-translational modification. Curr Drug Targets. 7(5):597-606. 2006.
•Allahverdian S, Wojcik KR, Dorscheid DR. Airway Epithelial Wound Repair: Role of Carbohydrate Sialyl Lewis X. Am J Physiol Lung Cell Mol Physiol. Jun 2. [Epub ahead of print] 2006.
•Davani EY, Boyd JH, Dorscheid DR, Wang Y, Meredith A, Chau E, Singhera GK, Walley KR. Cardiac ICAM-1 mediates leukocyte-dependent decreased ventricular contractility in endotoxemic mice. Cardiovasc Res. Jul 14; [Epub ahead of print] 2006.
•Davidson WJ, Dorscheid DR, Spragg R, Schulzer M, Mak E, Ayas NT. Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. Crit Care. 10(2):R41. doi:10.1186/cc4851. 2006.
•”Dorscheid DR#, Patchell BJ#, Estrada O, Marroquin BA, Tse R, White SR. Effects of corticosteroid-induced apoptosis on airway epithelial wound closure in vitro. Am J Physiol Lung Cell Mol Physiol. Jun 2. [Epub ahead of print] 2006.
•# Authors are equal contributors and co-first authors.”
•Patchell BJ and Dorscheid DR. Repair of the injury to respiratory epithelial cells characteristic of asthma is stimulated by Allomyrina dichotoma agglutinin specific serum glycoproteins. Clin Exp Allergy. 36(5):585-93. 2006.
•Singhera GK, Chan TS, Cheng JY, Vitalis TZ, Hamann KJ, Dorscheid DR. Apoptosis of viral-infected airway epithelial cells limit viral production and is altered by corticosteroid exposure. Respir Res. 7(1):78. 2006.
•Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR. Myocardial hypoxia-inducible HIF-1?, VEGF and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia. Am J Physiol Heart Circ Physiol. 293:H448-H456. 2007.
•MacRedmond RE, Greene CM, Dorscheid DR, McElvaney NG, O’Neill SJ. Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. Respir Res. 8:84. 2007.
•Patchell, Benjamin; Wojcik, Kimberly; Yang, Ting-Ling; White, Steven; Dorscheid, Delbert. Glycosylation and Annexin II cell surface translocation mediate airway epithelial wound repair. Am J Physiol Lung Cell Mol Physiol. 293(2):L354-63. [Epub ahead of print May 18] 2007.
•Allahverdian S, Harada N, Singhera GK, Knight DA, Dorscheid DR. Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF. Am J Respir Cell Mol Biol. 38:153-60. 2008.
•Singhera GK, MacRedmond R, Dorscheid DR. Interleukin-9 and -13 inhibit spontaneous and corticosteroid induced apoptosis of normal airway epithelial cells. Exp Lung Res. 34:579-598. 2008.
•MacRedmond R, Singhera GK, Dorscheid DR. Erythropoietin inhibits respiratory epithelial cell apoptosis in a model of ALI. Eur Respir J. 33(6):1403-1414, 2009.
•Allahverdian S, Dorscheid DR. EGF receptor for glycosylation and ligand affinity and involved in airway epithelial repair. Clinical and Experimental Allergy [Epub Dec 2009] 40(4):607-18, 2010.
•MacRedmond R, Singhera G, Attridge S, Bahzad M, Fava C, Lai Y, Hallstrand T, Dorscheid D. Conjugated Linoleic Acid (CLA) improves airway hyperreactivity in overweight mild asthmatics. Clinical and Experimental Allergy [Epub June 10] 40(7):1071 – 1078, 2010.
•Marchant D, Singhera, GK Utokaparch S, Boyd B , Luo Z, Si X, Dorscheid DR, McManus BM, Hegele RG. Toll Like Receptor 4 mediated p38 Mitogen Activated Protein Kinase Activation is a Determinant of Respiratory Virus Entry and Tropism. Journal of Virology [Epub Aug 11] 84(21):11359-73, 2010.
•Wadsworth SJ, Atsuta R, McIntyre JO, Hackett T-L, Singhera GK, Dorscheid DR. Interleukin-13 and TH2 cytokine exposure triggers matrix metalloproteinase-7 mediated Fas ligand cleavage from bronchial epithelial cells. Journal of Allergy and Clinical Immunology [Epub 2010 Jul 10] 126(2):366-74, 374.e1-8, 2010.
•Tam A, Wadsworth S, Dorscheid D, Paul Man SF, Sin DD. The airway epithelium: More than just a structural barrier. Journal of Therapeutic Advances in Respiratory Disease [Epub 12 Dec 2010].