Position:
Professor
Division:
Neurology
Vision Statement:

By understanding better the role of monoamine neurotransmitters in the brain, we can address the significant problems associated with their dysfunctions, as in mood disorders or Parkinson’s disease.

Research Interests:

Parkinson’s disease, depression, role of dopamine, noradrenaline and serotonin in brain function, animal models of disease

Research Sumary:

I use in vivo brain imaging techniques such as PET and MRI to investigate the physiology and pathophysiology of monoaminergic systems and mechanisms of action of various therapeutic approaches.

Personal:

Ride and compete horses (Dressage), collect stray cats and drive fast.

Education:
University of Bordeaux, 1983, PhD. Neurophysiology
University of Bordeau, 1985, PhD Human Biology and behavior
Recent Publications:

(SELECTED)
Strome EM, Wheeler GH, Higley D, Loriaux DL, Suomi SJ, Doudet DJ “Intracerebroventricular corticotrophin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in non-human primates” PNAS 99:15749-15754 (2002)

McGeer P.L., Schwab C., Parent A., Doudet D.J., “Presence of reactive microglia in monkey substantia nigra years after MPTP administration” Ann. Neurol., 54:599-604 (2003)

Doudet D.J., Holden J.E. “”Sequential vs non-sequential measurement of density and affinity of dopamine D2 receptors with [11C]raclopride: 1: Effect of methamphetamine” J. Cereb. Blood Flow Metab , 23:1489-1494 (2003)

Rosa-Neto P., Doudet D.J., Cumming P. “Gradients of dopamine D1 and D2/3 binding sites in the basal ganglia of pig and monkey measured by PET” NeuroImage 22:1076-1083 (2004)

Doudet D.J., Allen R., Honey C., Schweikert A., Cornfeldt M. “In vivo evaluation of retinal pigment epithelial cell transplant by PET “ Exp. Neurol. 189:361-368 (2004)

Strome EM, Clark CM, Zis AP, Doudet DJ. “Electroconvulsive shock decreases binding to 5-HT2 receptors in non-human primates: an in vivo PET study with [18f]setoperone1″ Biol. Psychiatry 57:1004-1010 (2005)

Doudet D.J., Ruth T., Holden J.E. “Sequential vs Non sequential measurement of density and affinity of dopamine D2 receptors with [11C]raclopride: 2: Effects of DAT inhibitors” J. Cereb. Blood Flow Metab. 26:28-37 (2006)

Doudet D.J., Rosa-Netto P, Munk O, Ruth TJ, Jivan S., Cumming P. “Effects of age on markers for monoaminergic neurons of normal and MPTP-lesioned rhesus monkeys: A multi-tracer PET study” NeuroImage, 30:26-35 (2006)

Miklossy J. Doudet DJ, Schwab C, Yu S, McGeer EG, McGeer PL. “Role of ICAM-1 in persisting inflammation in Parkinson’s Disease and MPTP monkeys” Exp. Neurol. 197:275-283 (2006)

Strome E, Cepeda I, Sossi V, Doudet DJ “Evaluation of the integrity of the dopamine system in a rodent model of Parkinson’s disease: small animal pet compared to behavioral assessment and autoradiography” MIB 8:292-299 (2006)

Kim S, Doudet DJ, Studenov AR, Ruth TJ, Gambhir SS, McIntosh CHS “Quantitative micro positron emission tomography (PET) imaging for the in vivo determination of pancreatic islet graft survival” Nature Medicine 12:1423-1428 (2006)

Strome EM, Doudet DJ. Animal Models of Neurodegenerative Diseases: Insight from Imaging Studies”. MIB march 9:186-195 (2007)

Sossi V, Holden JE, Topping GS, Camborde ML, Kornelsen R, McCormick S, Greene J, Studenov AR, Ruth TJ, Doudet DJ “In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD” J. Cereb. Blood Flow Metab. 27:1407-1415 (2007)

Strome EM, Zis AP, Doudet DJ “Electroconvulsive shock enhances striatal D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats” I J. Psychiat. Neurosci. 32:193-202 (2007)

Cepeda I, Flores J, Cornfeldt M, O’Kusky J, Doudet DJ. “Human Retinal Pigment Epithelial Cell Implants Ameliorate Motor Deficits in Two Rat Models of Parkinson’s Disease” J. Neuropath. Exp. Neurol. 66:576-584 (2007)

Flores J, Cepeda I, Cornfeldt M, O’Kusky J, Doudet DJ. Characterization of Long Term Implants of Human Retinal Pigment Epithelial Cells Attached to Gelatin Microcarriers in a Rat Model of Parkinson’s Disease” J. Neuropath. Exp. Neurol. 66:585-596 (2007)

Doudet DJ. Neurodegenerative Diseases. Editorial – MIB 32:159-160 (2007)

Ostergaard SD, Olsen AK, Gramsbergen JB, Minuzzi L, Pedersen K, Jensen SB, Doudet DJ, Cumming P. MDMA-evoked changes in the binding of dopamine D2 receptor ligands in the striatum of rats with unilateral serotonin depletion. Synapse 64:70-82 (2010)

Phenix C, Rempel BP, Colobong K, Doudet DJ, Adam MJ, Clarke LA, Withers SG. Noninvasive Imaging of replacement therapy in vivo using PET: proof of concept for Gaucher Disease. PNAS 107:10842:10847 (2010)

Peterson E, Moller A, Doudet DJ, Bailey,CJ, Vang Hansen K, Rodell A, Linnet J, Gjedde A. Pathological gambling: relation of skin conductance response to dopamine neurotransmission and sensation seeking. Eur. Neurophsychopharmacol. 20:766-775 (2010)

Sossi V. Dinelle K, Schulzer M, Doudet DJ, de la Fuente-Fernandez R. Levodopa and pramipexole effect on presynaptic dopamine PET markers and estimated DA release. Eur. J. Nuc. Med. Mol. Imaging 37:2364-2370 (2010)

Linnet J, Moller A, Peterson E, Gjedde A, Doudet DJ. Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling. Addiction 106:383-390 (2011)

Landau A, Chakaravarty M, Clark C, Zis A, Doudet DJ. Electroconvulsive therapy alters dopamine signalling in the striatum of non-human primates. Neuropsychopharmacol. 36: 511-518 (2011)

Landau AM, Clark C, Jivan S, Doudet DJ. Antiparkinsonian mechanism of electroconvulsive therapy in MPTP-lesioned non human primates. Neurodegenerative Dis 2011 in press

Ma Y, Peng S, Spetsieris PG, Sossi V, Eidelberg D, Doudet DJ. Abnormal metabolic brain networks in a non human primate model of parkinsonism. J.Cereb.Blood Flow Metab. 2011 in press

Awards & Recognition:

Roche Neurological prize (1986)
NIH Fogarthy Fellowship, USA (1986-1988)
NARSAD young investigator award (1998)
Martin HoffmanAward for Excellence in Research (2003)