Position:
Professor
Division:
Critical Care Medicine
Education:
A.B. Princeton University Biology (Cum Laude)
MD University of Toronto
Recent Publications:
  • Sutherland AM, Sham AHP, Wurfel MM, Walley KR, Russell JA. A Non-synonymous polymorphism of IRAK4 associated with increased prevalence of Gram-positive infection and decreased response to Toll-like receptor ligands. J Innate Immune (In press, 2011).
  • Boyd JH, Forbes J, Nakada T, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med October 21, 2010 [Epub ahead of print].
  • Gordon AC, Russell JA, Walley KR, Singer J, Ayers D, Stors MM, Holmes CL Hebert JC, Cooper DJ, Mehta S, Granton JT, Cook DJ, Presneill JJ for the Vasopressin and Septic Shock Trail (VASST) Investigators.  The effects of vasopressin on acute kidney injury in septic shock.  Intensive Care Med 36(1): 83. 2010.
  • Gordon AC, Russell JA, Walley KR, Singer J, Ayers D, Stors MM, Holmes CL Hebert JC, Cooper DJ, Mehta S, Granton JT, Cook DJ, Presneill JJ for the Vasopressin and Septic Shock Trail (VASST) Investigators. The effects of vasopressin on acute kidney injury in septic shock.  Intensive Care Med 36(1):83, 2010.
  • Nakada T, Boyd JH,Aguirre-Hernandez R, Thain K, Thair S, Nakada E, McConechy M, Russell JA, Walley KR. Beta2-receptor gene polymorphism is associated with mortality in septic shock. Am J Resp Crit Care Med 181: 143-149, 2010.
  • Nakada T, Boyd JH,Aguirre-Hernandez R, Thain K, Thair S, Nakada E, McConechy M, Russell JA, WalleyKR. Beta2-receptor gene polymorphism is associated with mortality in septicshock. Am J Resp Crit Care Med 181:143-149, 2010.
  • Russell JA, Boyd JH, Nakada T, Thair SA, Walley KR. Molecular mechanisms of sepsis. Contrib Microbiol (In press, 2010).
  • Russell JA, Gordon AC, Walley KR. Interaction of vasopressin infusion, corticosteroid treatment and mortality of septic shock. Corticostoids and the original vasopressin and septic shock trial subgroups. Crit Care Med 38(1) 338-339, 2010.
  • Russell JA, Wally KR.  Vasopressin and its immune effects in septic shock. J Innate Immun 2:446-360, 2010.
  • Russell JA.  Are copy number variants of defensins a key source of variation in the orchestrated response to infection? Anesthesiol 112(6):1307-1308, 2010.
  • Russell JA.  Vasopressin in septic shock. Minerva Anestesiol (In press, 2010).
  • Russell JA. Gene expression in human sepsis. What have we learned? Crit Care 15:121, 2010.
  • Russell JA. Prone positioning in patients with acute respiratory distress syndrome. JAMA. 303(9):832, 2010 (Letter).
  • Russell JA. Vasopressin in the management of septic shock. Crit Care (In press, 2010).
  • Russell JA. Vasopressin, levosimendan and cardiovascular function in septic shock. Crit Care Med 38(10): 2071-2073, 2010.
  • Thair SA, Walley KR, Nakada T, McConechy MK, Boyd JH, Russell JA. A single nucleotide polymorphism in NF-B inducing kinase is associated with mortality in septic shock. J Immunol  (In press, 2011).
  • von Dadelszen P, Payne B, Li J, Ansermino JM, Broughton-Pipkin F, Cote AM, Douglas JM, Gruslin A, Hutcheon JA, Joseph KS, Kyle PM, Lee T, Loughna P, Menzies JM, Merialdi M, Millman AL, Moore MP, Moutquin JM, Ouellet AB, Smith GN, Walker JJ, Walley KR, Walters BN, Widmer M, Lee SK, Russell JA, Magee LA for the PIERS Study Group. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation fo the fullPIERS model. Lancet December 23, 2010 [Epub ahead of print].
  • Hodder RV, Hall R, Russell JA, Fisher HN, Lee B.  Early drotrecogin alpha (activated) administration in severe sepsis is associated with lower mortality: a retrospective analysis of the Canadian ENHANCE cohort.  Crit Care. 13(3):R78, 2009.
  • Russell JA, Walley KR, Singer J, Gordon AC, Hébert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D for the VASST investigators. Interaction of vasopressin infusion, corticosteroid treatment and mortality of septic shock. Crit Care Med 37(3):811-818, 2009.
  • Russell JA. Vasopressin and its copilot copeptin in sepsis and septic shock. Crit Care Med 37(2): 749 – 750, 2009.
  • Shaw DM, Sutherland AM, Russell JA, Lichtenstein SV, Walley KR.  Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery.  Crit Care 29;13(1):R9, 2009.
  • Meade MO, Cook DJ, Guyatt, GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P, Lapinsky S, Baxter A, Russell J, Skrobnik Y, Ronco JJ, Stewart TE, and LOVS investigators.  Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 299(6): 637 – 645, 2008.
  • Morris P, Vincent JL, Russell JA, Wheeler A, Bernard GR. A double-blind placebo-controlled study to evaluate the safety and efficacy of procysteine in the treatment of patients with acutr respiratory distress syndrome. Crit Care Med 36 (3): 782 – 788, 2008.
  • Russell JA, Walley KR, Singer J, Gordon AC, Hébert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D for the VASST investigators. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 358: 877 – 887, 2008.
  • Russell JA, Walley KR.Vasopressin in septic shock. N Engl J Med 358: 2736 -2738, 2008.
  • Russell JA, Wellman H, Walley KR. Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry. Hum Genet 123: 661 – 663, 2008.
  • Russell JA. The current management of septic shock. Minerva Medica 99(5): 431 – 458, 2008.
  • Wurfel MM, Gordon AC, Holden TD, Radella F, Strout J, Kalikawa O, Ruzinski JT, Rona G, Black RA, Stratton S, Jarvik GP, Hajjar AM, Nickerson DA, Rieder M, Sevransky J, Maloney JP, Moss M, Martin G, Shanholz C, Garcia J, Gao L, Brower R, Barnes KC, Walley KR, Russell JA, Marin TR. TLR-1 polymorphisms confer higher innate immune responses and susceptibility to death in sepsis. Am J Resp Crit Care Med 178: 710 – 720, 2008.
  • Manocha S, Russell JA, Sutherland AM, Wattanathum A, Walley KR. Fibrinogen-beta gene haplotype clade is associated with mortality in sepsis. J Infection  54:572-7 2007  (doi:10.1016/j.inf.2006.10.001).
  • Menzies J, Magee LA, Macnab YC, Ansermino JM, Li J, Douglas MJ, Gruslin A, Kyle P, Lee SK, Moore MP, Moutquin JM, Smith GN, Walker JJ, Walley KR, Russell JA, von Dadelszen P. Current CHS and NHBPEP criteria for severe preeclampsia do not uniformly predict adverse maternal or perinatal outcomes. Hypertens Pregnancy.  26:447-62. 2007.
  • Russell JA. Management of sepsis. N Engl J Med 2007; 356: 1178-82 (letter reply).
  • Russell JA. Vasopressin in septic shock.  Crit Care Med. 35:S609-15. 2007.
  • Russell JA. Vasopressin in vasodilatory and septic shock. Curr Opin Crit Care. 13:383-91. 2007.
  • Tokunaga, C, Russell JA, Walley KR. Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemia.  Crit Care Med. 35:1341-7. 2007.
  • Walley KR, Russell JA. Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis. Crit Care Medicine 2007; 35(1): 12-17.
  • Bernard GR, Dhainaut JF, PhD, Russell JA, Shorr A, Macias WL, Nelson  DR, Sundin DP. Protein C Concentrations in Severe Sepsis: Early Directional Change in Plasma Levels Predict Outcome. Crit Care 2006; ccforum.com/content/10/3/R92  (open access).
  • Fink M, et al. The future of our specialty: critical care medicine a decade from now. Crit Care Med (In press 2006).
  • Gordon A, Rusell JA. Goal-directed therapy: how long can we wait? Crit Care 2006; 9(6): 647-8.
  • Gordon A, Russell JA. Goal-directed therapy: how long can we wait? Crit Care 2006; 9(6): 647 -8.
  • Manocha S, Gordon A, Ebrahim S, Groshaus H, Walley KR, Russell JA. Inhaled beta-2 agonist salbumtamol in acute lung injury: an association with improvement in acute lung injury. Crit Care 2006; 10: R12-R18.
  • Manocha S, Gordon A, Ebrahim S, Groshuas H, Walley KR, Russell JA. Inhaled beta-2 agonist salbumtamol in acute lung injury: an association with improvement in acute lung injury. Crit Care 2006; 10: R12 -R18.
  • Rice TW, Wheeler AP, Morris PE, Paz HL, Russell JA, Edens, TR, Bernard GR. Safety and efficacy of affinity purified, anti-tumor necrosis factor-alpha, ovine Fab for injection (CytoFAb™) in severe sepsis. Crit Care Medicine 2006; 34 (9): 2271 -2281.
  • Russell JA. Management of sepsis. N Engl J Med 2006; 355 (16): 699-713.
  • Sutherland A, Gordon A, Russell JA. Are vasopressin levels increased or decreased in septic shock? Crit Care Medicine 2006; 34 (2): 542 -543.
  • Sutherland A, Gordon A, Russell JA. Are vasopressin levels increased or decreased in septic shock? Crit Care Medicine 2006; 34 (2): 542-543.
  • Wheeler AP, Bernard GR, Thompson BT, et al of NHLBI ARDSnet. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med 2006; 354 (21): 2213 -2211. (J. Russell was Site PI of UBC site of ARDSnet).
  • Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, de Boisblanc B and NHLBI ARDSnet. Comparison of two fluid management strategies in acute lung injury. N Engl J Med 2006; 354 (24): 2564 -2575. (J. Russell was Site PI of UBC site of ARDSnet).