Position:
Professor
Division:
Hematology
Research Sumary:

The role of cytokines in regulation of the generation of lymphohemopoietic cells and in inflammatory and neoplastic disease.  My particular interest is in interleukin-3.  My laboratory was one of the first to purify IL-3 and document its broad range of activities on hemopoietic cells, its importance in mast cell pathophysiology and its role in leukemogenesis. Current research is focussed on signal transduction mechanisms and their perturbation in disease, with an emphasis on two novel proteins we discovered, M-Ras and the Ras Pathway Modulator, RPM. My laboratory has also developed a novel approach to generating monoclonal antibodies and is using it to develop novel therapeutic agents and new tools for research into intracellular processes and gene therapy.

Education:
B. Med. Sc. (Honours) University of Melbourne Cellular Immunology: Immunoregulation
M.B.B.S. University of Adelaide Medicine
Ph.D. University of Melbourne B-cell tolerance & activation
Recent Publications:
  • Guo X, Stratton L, and Schrader JW. Expression of activated M-Ras in hematopoietic stem cells initiates leukemogenic transformation, immortaliztion and preferential differentiation to mast cell. Oncogene, 2006. (in press).
  • Guo X, Stratton L, and Schrader JW. Expression of activated M-Ras in hematopoietic stem cells initiates leukemogenic transformation, immortaliztion and preferential differentiation to mast cell. Oncogene, 2006. (in press).
  • Kolobova E, Efimov A, Kaerina I, Rishi AK, Schrader JW, Ham A, Larocca MC & Goldenring JR. Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. Exp Cell Res 315:542-555, 2009.
  • Lorén CE, Schrader JW, Ahlgren U & Gunhaga L.  FGF signals induce Caprin2 expression in the vertebrate lens. Differentiation 77:386-394, 2009.