Position:
Professor
Division:
Neurology
Research Interests:
  • c Neuroscience
  • Computational Neuroscience
  • Electrophysiology
  • Functional Magnetic Resonance Imaging
  • MRI
  • Parkinson’s Disease
  • Virtual R
Education:
B.Eng summa cum laude McMaster University, Hamilton, Ontario Physics
MD University of Toronto
FRCP
Recent Publications:
  • Wing-Lok Au, Ni Lei, Meeko M K Oishi, Martin J McKeown. (2010).  L-Dopa induces under-damped visually guided motor responses in Parkinson’s disease.  Exp Brain Res 202: 3. 553-559 May.
  • Appel-Cresswell S, Galley S, de la Fuente-Fernandez R, McKeown MJ. (2010)  Imaging of Compensatory Mechanisms in Parkinson’s disease. Current Opinion in Neurology 23: 4. 407-412 Aug.
  • Chen X , Wang ZJ, McKeown MJ. (2010). Asymptotic Analysis of Robust LASSOs in the Presence of Noise with Large Variance   IEEE Transactions on Information Theory 56:10. 5131 – 5149 Oct.
  • Kokotilo KJ, Eng JJ, McKeown MJ, Boyd LA. (2010).  Greater activation of secondary motor areas is related to less arm use after stroke. Neurorehabil Neural Repair 24:1. 78-87 Jan.
  • Ng B, Palmer S, Abugharbieh R, McKeown MJ. (2010).  Focusing effects of L-dopa in Parkinson’s disease.   Hum Brain Mapp 31: 1. 88-97 Jan.
  • Palmer SJ, Lee P W-H, Wang ZJ, Au W-L, McKeown MJ. (2010).  Theta, Beta But Not Alpha-Band EEG Connectivity Has Implications For Dual Task Performance In Parkinson¹s Disease Parkinsonism and Related Disorders 16: 393-397.
  • Palmer SJ, Li J, Wang ZJ, McKeown MJ. (2010). Joint amplitude and Connectivity compensatory mechanisms in Parkinson’s disease. Neuroscience 166: 4.1110-1118 Apr.
  • Ma Z, Wang JZ, McKeown MJ. Probabilistic Boolean Network Analysis of Brain Connectivity in Parkinson’s Disease. IEEE Journal of Selected Topics In Signal Processing (special Issue on fMRI Analysis for Human Brain Mapping). vol. 2, issue 6, pp. 975-985.
  • Ng B, Abugharbieh R, McKeown MJ. “Discovering Sparse Functional Brain Networks Using Group Replicator Dynamics”. Accepted to Information Processing in Medical Imaging (IPMI), Williamsburg-USA, 2009.
  • Ng B, Abugharbieh R, McKeown MJ. “Functional Segmentation of fMRI Data using Adaptive Non-negative Sparse PCA (ANSPCA)”. Accepted to Medical Image Computing and Computer Assisted Intervention (MICCAI), London-UK, 2009.
  • Palmer S J, M. EL, T H, GR M, Troiano A, McKeown MJ. Levodopa-sensitive, dynamic changes in effective connectivity during simultaneous movements in Parkinson’s Disease. Neuroscience. 158(2):693-704. 2009.
  • Palmer SJ, Ng B, Abugharbieh R, Eigenraam L, and McKeown MJ. Motor reserve and novel area recruitment: amplitude and spatial characteristics of compensation in Parkinson’s disease. European Journal of Neuroscience, 2009, 29:  2187-2196.
  • Uthama A, Abugharbieh R, PS J, Traboulsee A, McKeown MJ. SPHARM-Based Spatial fMRI Characterization with Intersubject Anatomical Variability Reduction IEEE Journal of Selected Topics In Signal Processing (special Issue on fMRI Analysis for Human Brain Mapping).2009, vol. 2, issue 6, pp. 907-918.
  • Wang ZJ, Lee P and McKeown MJ. A Novel Segmentation, Mutual Information Network Frame-work for EEG Analysis of Motor Tasks BioMedical Engineering OnLine, 2009.
  • Chiang J, Wang ZJ, McKeown MJ. A Hidden Markov, Multivariate Autoregressive (HMM-mAR) Network Framework for Analysis of Surface EMG (sEMG) Data. Signal Processing, IEEE Transactions on. 2008;56(8):4069-4081.
  • Chiang J, Wang ZJ, McKeown MJ. A Windowed Eigenspectrum Method for Multivariate sEMG Classification During Reaching Movements. Signal Processing Letters, IEEE. 2008;15:293-296.
  • Lewis M, Smith  A, Styner M, Gu H, Poole R, Zhu H, Li Y, Barbero X, Gouttard S, McKeown M, Mailman R, Huang X. Asymmetrical lateral ventricular enlargement in Parkinsons disease. European Journal of Neurology (in press).
  • Li J, Wang ZJ, Eng JJ, McKeown MJ. Bayesian Network Modeling for Discovering “Dependent Synergies” Among Muscles in Reaching Movements. Biomedical Engineering, IEEE Transactions on. 2008;55(1):298-310.
  • McKeown M, Uthama A, Abugharbieh R, Palmer S, Lewis M, Huang X. Shape (But Not Volume) Changes in the Thalami in Parkinson Disease. BMC Neurology. 2008;8(8).
  • Nandhagopal R, McKeown MJ, Stoessl AJ. Functional imaging in Parkinson disease. Neurology. 2008;70(16 Pt 2):1478-1488.
  • Ng B, Abugharbieh R, Xuemei H, McKeown M. Spatial Characterization of fMRI Activation Maps Using Invariant 3D Moment Descriptors. IEEE Transactions on Medical Imaging. (in press).
  • Palmer S J., M. EL, T H, GR M, Troiano A, McKeown M. Levodopa-sensitive, dynamic changes in effective connectivity during simultaneous movements in Parkinson’s Disease. Neuroscience. 2008:(in press).
  • Uthuma A, Abugharbieh R, McKeown MJ. SPHARM-Based Spatial Fmri  Characterization with Intersubject Anatomical Variability Minimization. IEEE Journal of Select Topics in Signal Processing: Special issue on fMRI Analysis for Human Brain Mapping (in press).
  • Zheng M, Wang ZJ, McKeown MJ. Probabilistic Boolean Network Analysis of Brain Connectivity in Parkinson’s Disease. IEEE Journal of Select Topics in Signal Processing: Special issue on fMRI Analysis for Human Brain Mapping (in press).
  • Huang X, Lee YZ, McKeown M, et al. Asymmetrical ventricular enlargement in Parkinson’s disease. Movement Disorders. 2007;22(11):1657-1660.
  • Lewis MM, Slagle CG, Smith AB, et al. Task specific influences of Parkinson’s disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries. Neuroscience. 2007;147(1):224-235.
  • McKeown MJ, Li J, Huang X, et al. Local linear discriminant analysis (LLDA) for group and region of interest (ROI)-based fMRI analysis. Neuroimage. 2007;37(3):855-865.
  • Saab R, Yilmaz O, McKeown MJ, Abugharbieh R. Underdetermined Anechoic Blind Source Separation via lq-Basis-Pursuit. Signal Processing, IEEE Transactions on. 2007;55(8):4004-4017.
  • Liao R, McKeown MJ, Krolik JL. Isolation and minimization of head motion-induced signal variations in fMRI data using independent component analysis. Magnetic Resonance in Medicine. 2006;55(6):1396-1413.
  • McKeown MJ, Palmer SJ, Au WL, McCaig RG, Saab R, Abu-Gharbieh R. Cortical muscle coupling in Parkinson’s disease (PD) bradykinesia. Journal of Neural Transmission. 2006;Supplementum.(70):31-40.
  • McKeown MJ, Wang ZJ, Abugharbieh R, Handy TC. Increasing the effect size in event-related fMRI studies. Engineering in Medicine and Biology Magazine, IEEE. 2006;25(2):91-101.