The ability to confirm equivalent quality of life after direct, non-directed and paired exchange living kidney donation would be a considerate benefit in promoting non-directed and paired exchange living kidney donation thus potentially decreasing deceased kidney donor waiting lists and time to kidney transplantation.
By investigating the associations and etiology of complications post kidney transplantation, such complications may be avoided in the future.
Living kidney donor quality of life; complication after kidney transplantation; complications of transplant failure and repeat kidney transplantation; metabolic consequences of kidney transplantation
It has been shown that donating a kidney to a loved one (direct living kidney donation) does not not decrease the donor’s quality of life (QOL) after the donor surgery. However very little is known about the quality of life after donor surgery if the donor does not know the recipient of the kidney (non-directed and paired exchange living kidney donation ). My current study examines this question by asking donors to complete QOL surveys before and after the donor surgery. We will then compare the results between direct donors with non-directed and paired exchange living kidney donors. The ability to confirm equivalent quality of life after direct, non-directed and paired exchange living kidney donation would be a considerate benefit in promoting non-directed and paired exchange living kidney donation thus potentially decreasing deceased kidney donor waiting lists and time to kidney transplantation.
My research also involves assessing the etiology and factors associated with complications after kidney transplantation and kidney transplant failure in an attempt to reduce or avoid such complications in the future.
- Johnston O. Kidney disease: A guide for living. Book review. Am J Transplant 2011 Oct; 11(11):2532.
- Johnston O, Cassidy H, O’Connell S, O’Riordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T. Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods. Proteomics Clin Appl. 2011 May 30.
- Browne S, Gill J, Dong J, Rose C, Johnston O, Zhang P, Landsberg D, Gill JS. The Impact of Pancreas Transplantation on Kidney Allograft Survival. Am J Transplant. 2011 Sept; 11(9):1951-8.
- Günther OP, Lin D, Balshaw RF, Ng RT, Hollander Z, Wilson-McManus J, McMaster WR, McManus BM, Keown PA; Biomarkers in Transplantation Team. Effects of sample timing and treatment on gene expression in early acute renal allograft rejection. Transplantation. 2011 Feb 15;91(3):323-9.
- J. Gill, O. Diec, D.N. Landsberg, C. Rose, O. Johnston, P.A. Keown, J.S. Gill. Opportunities to deter transplant tourism exist before referral for transplantation and during work-up and management of transplant candidates. Kidney Int 2011 Jan 12 (Epub ahead of print)
- O. Johnston, D. Jaswal, J.S. Gill, S. Doucette, D.A. Fergusson, G.A. Knoll. Treatment of Polyomavirus Infection in Kidney Transplant Recipients: A Systematic Review. Transplantation 2010; 89(9): 1057-1070.
- J.S. Gill, D. Landsberg, O. Johnston, R.J. Shapiro, A.B. Magill, V. Wu, K. Tinkham, P.A. Keown. Screening for de-novo anti-HLA antibodies in non-sensitized kidney transplant recipients does not predict acute rejection. Transplantation 2010;89 (2):178-184.
- Transplant Research Foundation of BC Venture Grant 2011-2012