Position:
Professor
Division:
Hematology
Education:
MD Erasmus University, Rotterdam, The Netherlands Internal Medicine
PhD University of Amsterdam, The Netherlands Experimental Hematology
Recent Publications:
  • Chiang YJ, Calado RT, Hathcock KS, Lansdorp PM, Young NS & Hodes RJ. Telomere length is inherited with resetting of the telomere set point. Proc Natl Acad Sci USA 107: 10148-10153, 2010.
  • Falconer E, Chavez E, Henderson A & Lansdorp PM. Chromosome orientation fluorescence in situ hybridization to study sister chromatid segregation in vivo. Nat Protoc 5: 1362-1377, 2010.
  • Falconer E, Chavez EA, Henderson A, Poon SSS, McKinney S, Brown L, Huntsman DG & Lansdorp PM. Identification of sister chromatids by DNA template strand sequences. Nature 463: 93-7, 2010.
  • Gourronc FA, Robertson MM, Herrig AK, Lansdorp PM, Goldman FD & Klingelhutz AJ. Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA component, TERC.  Exp Dermatol  Volume 19, Issue 3, Date: March 2010, Pages: 279-288.
  • Kimura M, Gazitt Y, Cao X, Zhao X, Lansdorp PM & Aviv A. Synchrony of telomere length among hematopoietic cells. Exp Hematol 38: 854-859, 2010.
  • Banath JP, Banuelos CA, Klokov D, MacPhail SM, Lansdorp PM & Olive PL. Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells.  Exp Cell Res 315: 1505-1520, 2009.
  • Breakey VR, Meyn S, Ng V, Allen C, Dokal I, Lansdorp PM, Abla O & Dror Y. Hepatitis-associated aplastic anemia presenting as a familial bone marrow failure syndrome.  J Pediatr Hematol Oncol 31: 884-887, 2009.
  • Calado RT, Regal JA, Hills M, Yewdell WT, Dalmazzo LF, Zago MA, Lansdorp PM, Hogge D, Chanock SJ, Estey EH, Falcao RP & Young NS. Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia.  Proc Natl Acad Sci USA 106: 1187-1192, 2009.
  • Calado RT, Regal JA, Kleiner DE, Schrump DS, Peterson NR, Pons V, Chanock SJ, Lansdorp PM & Young NS. A spectrum of severe liver and blood disorders associate with telomerase mutations.  PLoS One 4: e7926 2009.
  • Decker ML, Chavez E, Vulto I & Lansdorp PM. Telomere length in Hutchinson-Gilford progeria syndrome.  Mech Ageing Dev 130: 377-383, 2009.
  • Falconer E, Chavez EA, Henderson A, Poon SSS, McKinney S, Brown L, Huntsman DG & Lansdorp PM. Identification of sister chromatids by DNA template strand sequences.  Nature 463: 93-7, 2009.
  • Hills M & Lansdorp PM. Short telomeres resulting from heritable mutations in the telomerase reverse transcriptase gene predispose for a variety of malignancies.  Ann N Y Acad Sci 1176: 179-190, 2009.
  • Hills M, Lucke K, Chavez EA, Eaves CJ & Lansdorp PM. Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA).  Blood 113: 5765-5775, 2009.
  • Lansdorp PM. Telomeres and disease.  EMBO J 28: 2532-2540, 2009.
  • Alder JK, Chen JJ, Lancaster L, Danoff S, Su SC, Cogan JD, Vulto I, Xie M, Qi X, Tuder RM, Phillips JAI, Lansdorp PM, Loyd JE & Armanios MY. Short telomeres are a risk factor for idiopathic pulmonary fibrosis.  Proc Natl Acad Sci USA 105: 13051-13056, 2008.
  • Aubert G & Lansdorp P. Telomeres and aging.  Physiol Rev 82: 557-579, 2008.
  • Banuelos CA, Banath JP, MacPhail SH, Zhao J, Eaves CJ, O’Conner MD, Lansdorp PM & Olive PL. Mouse but not human embryonic stem cells are deficient in repair of DNA double-strand breaks induced by ionizing radiation.  DNA Repair 7: 1471-1483, 2008.
  • Berger C, Jensen MC, Lansdorp PM, Gough M, Elliott C & Riddell SR. Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates.  J Clin Invest 118: 294-305, 2008.
  • Goldman FD, Aubert G, Klingelhutz AJ, Hills M, Cooper SR, Hamilton WS, Schlueter A, Lambie K, Eaves CJ & Lansdorp PM. Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita.  Blood 111: 4523-4531, 2008.
  • Halaschek-Wiener J, Vulto I, Fornika D, Collins J, Connors JM, Le ND, Lansdorp PM & Brooks-Wilson A. Reduced telomere length variation in healthy oldest old.  Mech Ageing Dev 129: 638-41, 2008.
  • Lansdorp PM. Telomeres, stem cells and hematology.  Blood 111: 1759-1766, 2008.
  • Liu Y, Bohr VA & Lansdorp P. Telomere, telomerase and aging.  Mech Ageing Dev 129: 1-2, 2008.
  • Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM & Alter BP. TINF2, a component of the Shelterin telomere protection complex, is mutated in dyskeratosis congenita.  Am J Hum Genet 82: 501-509, 2008.
  • Tsangaris E, Adams SL, Yoon G, Chitayat D, Lansdorp P, Dokal I & Dror Y. Ataxia and pancytopenia caused by a mutation in TINF2.  Hum Genet 124: 507-13, 2008.
  • Vrisekoop N, van Gent R, de Boer AB, Otto SA, Borleffs JCC, Steingrover R, Prins JM, Kuijpers TW, Wolfs TFW, Geelen SPM, Vulto I, Lansdorp P, Tesselaar K, Borghans JAM & Miedema F. Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging.  J Immunol 181: 1573-1581, 2008.
  • Alter BP, Baerlocher GM, Savage SA, Chanock SJ, Weksler BB, Willner JP, Peters JA, Giri N & Lansdorp PM. Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita.  Blood 110: 1439-1447, 2007.
  • Armanios MY, Chen JJ-L, Cogan JD, Alder JK, Ingersoll RG, Xie M, Markin C, Lawson WE, Vulto I, Phillips III JA, Lansdorp PM, Greider CW & Loyd JE. Telomerase mutations in families with idiopathic pulmonary fibrosis.  N Engl J Med 356: 1317-1326, 2007.
  • Baerlocher GM, Rice K, Vulto I & Lansdorp PM. Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around one year of age.  Aging Cell 6: 121-123, 2007.
  • Baerlocher GM, Sloand EM, Young NS & Lansdorp PM. Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size.  Exp Hematol Epub ahead of print  2007.
  • Calado RT, Graf SA, Wilkerson KL, Kajigaya S, Ancliff PJ, Dror Y, Chanock SJ, Lansdorp PM & Young NS. Mutations in the SBDS gene in acquired aplastic anemia.  Blood 110: 1141-1146, 2007.
  • Lansdorp PM. Immortal strands? Give me a break.  Cell 129: 1244-1247, 2007.
  • Ouyang Q, Baerlocher G, Vulto I & Lansdorp PM. Telomere length in human natural killer cell subsets.  Ann N Y Acad Sci 1106: 240-252, 2007.
  • Röth A, Dürig J, Himmelreich H, Bug S, Siebert R, Dührsen U, Lansdorp PM & Baerlocher GM. Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia (T-PLL).  Leukemia Epub ahead of print 2007.
  • Sharma S, Stumpo DJ, Balajee AS, Bock CB, Lansdorp PM, Brosh RM, Jr. & Blackshear PJ. RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.  Mol Cell Biol 27: 1784-1794, 2007.
  • Shepherd BE, Kiem H-P, Lansdorp PM, Dunbar CE, Aubert G, Larochelle A, Seggewiss R, Guttorp P & Abkowitz JL. Hematopoietic stem cell behavior in non-human primates.  Blood 110: 1806-1813, 2007.
  • Westin ER, Chavez E, Lee KM, Gourronc FA, Riley S, Lansdorp PM, Goldman FD & Klingelhutz AJ. Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts.  Aging Cell 6: 383-394, 2007.
  • Xin ZT, Beauchamp A, Calado RT, Bradford JW, Regal JA, Shenoy A, Liang Y, Lansdorp PM, Young NS & Ly H. Functional characterization of natural telomerase mutations found in patients hematological disorders.  Blood 109: 524-532, 2007.
  • Baerlocher GM, Vulto I, de Jong G & Lansdorp PM. Flow cytometry and FISH to measure the average length of telomeres (flow FISH).  Nature Protocols 1: 2365-2376, 2006.
  • Cheung I, Schertzer M, Rose A & Lansdorp PM. High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans.  Nucleic Acids Res 34: 96-103, 2006.
  • Lansdorp PM. Stress, social rank and leukocyte telomere length.  Aging Cell 5: 583-584, 2006.
  • Savage SA, Stewart BJ, Weksler BB, Baerlocher GM, Lansdorp PM, Chanock SJ & Alter BP. Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure.  Blood Cells, Molecules and Diseases 37: 134-136, 2006.