Infectious Diseases
University of British Columbia, MD
Recent Publications:

•Gill KK, Leligdowicz A, Luo M, Bielawny T, Brunham R, and Plummer FA. Identification of Four Novel HLA-A Alleles from an East African Population by High-Resolution Sequence-Based Typing. Hum. Immunol. 2006. 67:833-838.
•Keynan Y, Luo M, Lacap P, Brunham R, Plummer FA. Identification of two novel HLA-C alleles, Cw*070105 and Cw*1408, from East African women. Hum Immunol. 2006;67:359-362.
•Mak A, Rahmanian R, Lei V, Lawrence D, Krajden M, Brunham RC, Skowronski D, Li Y, Booth T, Goh SH, Petric M. Longitudinal Analysis of Genotype Distribution of Influenza A Virus from 2003 to 2005. J Clin Microbiol 2006. 44(10):3583-3588.
•Patrick DM, Petric M, Skowronski DM, Guasparini R, Booth TF, Krajden M, McGeer P, Bastien N, Gustafson L, Dubord J, MacDonald D, David ST, Srour L, Parker R, Andonov A, Isaac-Renton J, Loewen N, McNabb G, McNabb A, Goh S, Henwick S, Astell C, Guo JP, Drebot M, Tellier R, Plummer F, Brunham RC.  An outbreak of human coronavirus OC43 infection and serological cross-reactivity with SARS coronavirus.  Can J Infect Dis Med Microbiol 2006; 17(6): 330-336.
•See HR, Zakhartchouk AN, Petric M, Lawrence EJ, Mok CPY, Hogan RJ, Rowe T, Zitzow LA, Karunakaran KP, Hitt MM, Graham FL, Prevec L, Rini JM, Tingle AJ, Scheifele DW, Skowronski DM, Patrick DM, Voss TG, Babiuk LA, Gauldie J, Roper RL, Brunham R, Finlay BB.  Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus.”  J Gen Virol. 2006;87:641-650.
•Skowronski D, Woolcott JC, Tweed SA, Brunman R, Marra F.  Potential cost-effectiveness of annual influenza immunization for infants and toddlers: Experience from Canada.  Vaccine. 2006 May 8;24:4222-4232.
•Rey-Ladino J, Jiang X, Gabel BR, Shen C, and Brunham RC. Survival of Chlamydia muridarum within Dendritic Cells. Infect. Immun. 2007;75(8): 3707-3714.
•Skowronski DM, Li Y, Tweed SA, Tam TWS, Petric M, David ST, Marra F, Bastien N, Lee SW, Krajden M, Brunham RC: Protective measures and human antibody response during an avian influenza H7N3 outbreak in poultry in British Columbia, Canada. CMAJ 2007; 176(1): 47-53.
•Zaharik ML, Nayar T, White R, Ma C, Vallance BA, Straka N, Jiang X, Rey-Ladino J, Shen C, Brunham RC. Genetic profiling of dendritic cells exposed to live- or ultraviolet-irradiated Chlamydia muridarum reveals marked differences in CXC chemokine profiles. Immunology. 2007 Feb;120(2):160-72.
•Zakhartchouk AN, Sharon C, Satkunarajah M, Auperin T, Viswanathan S, Mutwiri G, Petric M, See RH, Brunham RC, and Finlay BB et al. Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: Implications for a subunit vaccine. Vaccine 2007. 25, 136-143.
•Brunham, RC and Rekart, ML. The arrested immunity hypothesis and the epidemiology of Chlamydia control. Sex. Transm. Dis. 2008; 35(1):53-4.
•Günther OP, Ogilvie G, Naus M, Young E, Patrick DM, Dobson S, Duval B, Noël PA, Marra F, Miller D, Brunham RC, Pourbohloul B. Protecting the next generation: what is the role of the duration of human papillomavirus vaccine-related immunity? J Infect Dis. 2008 Jun 15;197(12):1653-61.
•Jiang X, Shen C, Rey-Ladino J, Yu H, and Brunham RC.  Characterization of a murine dendritic cell line (JAWS II) and primary bone marrow derived dendritic cells (BMDCs) in Chlamydia antigen presentation and induction of protective immunity. Infect Immun. 2008; Jun;76(6):2392-401.
•Karunakaran, KP, Rey-Ladino, J, Stoynov, N, Berg K, Shen C, Jiang X, Gabel BR, Yu H, Foster LJ, Brunham RC.  Immunoproteomic discovery of novel T cell antigens from the obligate intracellular pathogen Chlamydia.  J Immunol.  2008; 180(4):2459-65.
•Marra F, Marra CA, Sadatsafavi M, Morán-Mendoza O, Cook V, Elwood RK, Morshed M, Brunham RC, Fitzgerald JM. Cost-effectiveness of a new interferon-based blood assay, QuantiFERON-TB Gold, in screening tuberculosis contacts. Int J Tuberc Lung Dis. 2008; 12(12):1414-24.
•Ness RB, Shen C, Bass D, Jackson C, Moysich K, Edwards R, Brunham RC. Chlamydia trachomatis serology in women with and without ovarian cancer. Infec Dis Obstet Gynecol 2008;2008:219672.
•Ness, RB, Soper DE, Richter HE, Randall H, Peipert JF, Nelson DB, Schubeck D, McNeeley SG, Trout W, Bass DC, Hutchison K, Kip K and Brunham RC.  Chlamydia antibodies, Chlamydia heat shock protein, and adverse sequelae after pelvic inflammatory disease: the PID Evaluation and Clinical Health (PEACH) Study.  Sex Transm Dis.  2008; 35(2): 129-135.
•Peterson TA, Luo M, Mao X, Brunham RC, Plummer FA. Identification of novel DPA1 allele, DPA1*010602, in an East African population. Hum Immunol. 2008; 69(12):885-6.
•Rekart, ML and Brunham, RC.  Debate.  Epidemiology of Chlamydial infection: Are we losing ground? Sex. Transm. Infect. 2008; 84: 87-91.
•Noël PA, Davoudi B, Brunham RC, Dubé LJ, Pourbohloul B. Time evolution of epidemic disease on finite and infinite networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Feb;79(2 Pt 2):026101.
•Ondondo BO, Brunham RC, Harrison WG, Kinyari T, Sheth PM, Mugo NR, Cohen CR. Frequency and magnitude of Chlamydia trachomatis elementary body- and heat shock protein 60-stimulated interferon gamma responses in peripheral blood mononuclear cells and endometrial biopsy samples from women with high exposure to infection. J Infect Dis. 2009 Jun 15;199(12):1771-9.
•Brunham RC, Rekart ML. Considerations on Chlamydia trachomatis disease expression. FEMS Immunol Med Microbiol. 2009; 55(2):162-6.
•Brunham RC. Infectious disease prevention and control: remember 1908 and imagining 2108. Can J Public Health. 2009; 100(1):5-8.
•Pourbohloul B, Ahued A, Davoudi B, Meza R, Meyers L, Skowronski D, Villasenor I, Galvan F, Cravioto P, Earn D, dushoff J, Fisman D, Edmunds WJ, Hupert N, Scarpino S, Trujillo J, Lutzow M, Morales J, Contreras A, Chavez C, Patrick D, Brunham RC.  Initial human transmission dynamics of the pandemic (H1N1) 2009 virus in North America. Influenza and Other Respiratory Viruses. 2009; 3(5):215-222.
•Yu H, Jiang X, Shen C, Karunakaran KP, Brunham RC. Novel Chlamydia muridarum T cell antigens induce protective immunity against lung and genital tract infection in murine models. J Immunol. 2009; 182(3):1602-8.
•Pourbohloul B, Ahued A, Davoudi B, Meza R, Meyers LA, Skowronski DM, Villaseñor I, Galván F, Cravioto P, Earn DJ, Dushoff J, Fisman D, Edmunds WJ, Hupert N, Scarpino SV, Trujillo J, Lutzow M, Morales J, Contreras A, Chávez C, Patrick DM, Brunham RC.  Initial human transmission dynamics of the pandemic (H1N1) 2009 virus in North America. Influenza Other Respi Viruses. 2009 Sep;3(5):215-22.
•Jiang X, Shen C, Yu H, Karunakaran P, Brunham RC.  Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection. Immunology. Sept 11 2009; (published online ahead of print).
•Myers GS, Mathews SA, Eppinger M, Mitchell C, O’Brien KK, White OR, Benahmed F, Brunham RC, Read TD, Ravel J, Bavoil PM, Timms P. Evidence that human Chlamydia pneumoniae was zoonotically acquired.  Journal of Bacteriology.  2009 Dec;191(23):7225-33.
•Xie F, Hu Y, Turvey SE, Magee LA, Brunham RM, Choi KC, Krajden M, Leung PC, Money DM, Patrick DM, Thomas E, von Dadelszen P. Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia.  BJOG 2010 Jan;117(1):99-108.
•Skowronski D, De Serres G, Crowcroft N, Janjua N, Boulianne N, Hottes T, Rosella L, Dickinson J, Gilca R, Sethi P, Ouhoummane N, Willison D, Rouleau I, Petric M , Fonseca K, Drews S, Rebbapragada A, Charest H, Hamelin M, Boivin G, Gardy J, Li Y, Kwindt T, Patrick D, Brunham R, for the Canadian SAVOIR Team. Association between the 2008-09 Seasonal Influenza Vaccine and Pandemic H1N1 Illness during Spring-Summer 2009: Four Observational Studies from Canada. PLoS Medicine. 7(4): e1000258. April 2010.
•Gardy J, Brunham RC. Navigating Transmission Networks with Genomics & Phylogenetic Trees. Future Virology. May 2010;5(3):251-253.
•Mitchell C, Hutton S, Myers G, Brunham R, Timms P. Chlamydia pneumoniae is genetically diverse in animals and appears to have crossed the host barrier to humans on (at least) two occasions. PLoS Pathogens. May 2010;6(5):1-11.
•Yu H, Jiang X, Shen C, Karunakaran K, Jiang J, Rosin N, Brunham RC. Chlamydia muridarum T cell antigens formulated with the adjuvant DDA/TDB induce immunity against infection that correlates with a high frequency of Gamma Interferon (IFN-γ)/Tumor Necrosis Factor Alpha and IFN-γ/Interleukin-17 double positive CD4+ T cells. Infection and Immunity. May 2010;78(5):2272-2282.
•Gottlieb S, Brunham R, Byrne G, Martin D, Xu F, Berman S. Introduction: The Natural History and Immunobiology of Chlamydia trachomatis Genital Infection and Implications for Chlamydia Control. Journal of Infectious Diseases. June 2010;201(Suppl 2):S85-S87.
•Gottlieb S, Martin D, Xu F, Byrne G, Brunham R. Summary: The Natural History and Immunobiology of Chlamydia trachomatis Genital Infection and Implications for Chlamydia Control. Journal of Infectious Diseases. June 2010;201(Suppl 2):S190-S204.
•Meza R, Pourbohloul B, Brunham RC. Birth cohort patterns suggest that infant survival predicts adult mortality rates. Journal of Developmental Origins of Health and Disease. June 2010;1(3):174-183.
•Karunakaran K, Yu H, Foster L, Brunham R. Development of a Chlamydia trachomatis T cell Vaccine. Human Vaccines. 2010;6(10):1-5.
•Cherkasov A, Hsing M, Zoraghi R, Foster LJ, See RH, Stoynov N, Jiang J, Kaur S, Lian T, Jackson L, Gong H, Swayze R, Amandoron E, Hormozdiari F, Dao P, Sahinalp C, Santos-Filho O, Axerio-Cilies P, Byler K, McMaster WR, Brunham RC, Finlay BB, Reiner NE. Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus. J Proteome Res. 2011 Mar 4;10(3):1139-50.
•Yu H, Karunakaran KP, Kelly I, Shen C, Jiang X, Foster LJ, Brunham RC. Immunization with live and dead Chlamydia muridarum induces different levels of protective immunity in a murine genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1 cells. J Immunol. 2011 Mar 15;186(6):3615-21. Epub 2011 Feb 4.
•Zoraghi R, See RH, Axerio-Cilies P, Kumar NS, Gong H, Moreau A, Hsing M, Kaur S, Swayze RD, Worrall L, Amandoron E, Lian T, Jackson L, Jiang J, Thorson L, Labriere C, Foster L, Brunham RC, McMaster WR, Finlay BB, Strynadka NC, Cherkasov A, Young RN, Reiner NE. Antimicrob Agents Chemother. 2011 May;55(5):2042-53.
•Collingro A, Tischler P, Weinmaier T, Penz T, Heinz E, Brunham RC, Read TD, Bavoil PM, Sachse K, Kahane S, Friedman MG, Rattei T, Myers GS, Horn M. Unity in variety–the pan-genome of the chlamydiae. Mol Biol Evol. 2011 Dec;28(12):3253-70. Epub 2011 Jun 20.
•Gardy JL, Johnston JC, Ho Sui SJ, Cook VJ, Shah L, Brodkin E, Rempel S, Moore R, Zhao Y, Holt R, Varhol R, Birol I, Lem M, Sharma MK, Elwood K, Jones SJ, Brinkman FS, Brunham RC, Tang P. Whole-genome sequencing and social-network analysis of a tuberculosis outbreak. N Engl J Med. 2011 Feb 24;364(8):730-9. Erratum in: N Engl J Med. 2011 Jun 2;364(22):2174.
•D’Souza C, Kronstad J, Taylor G, Warren R, Yuen M, Hu G, Jung W, Sham A, Kidd S, Tangen K, Lee N, Zeilmaker T, Sawkins J, McVicker G, Shah S, Gnerre S, Griggs A, Zeng Q, Bartlett K, Li W, Wang X, Heitman J, Stajich J, Fraser J, Meyer W, Carter D, Schein J, Krzywinski M, Kwon-Chung K, Varma A, Wang J, Brunham R, Fyfe M, Ouellette B, Siddiqui A, Marra M, Jones S, Holt R, Birren B, Galagan J, Cuomo C. Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. mBio. 2011. (in press).
•Zoraghi R, Warroll L, See RH, Strangman W, Popplewell WL, Gong H, Samaai T, Swayze RD, Kaur S, Vuckovic M, Finlay BB, Brunham RC, McMaster WR, Davies-Coleman MT, Strynadka NC, Andersen RJ, Reiner NE. MRSA pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities. J Biol Chem. 2011 Oct 26. [Epub ahead of print].