Position:
Clinical Assistant Professor
Division:
Allergy & Immunology
Research Interests:
  • Experimental Neurology
  • Tissue Culture
Research Sumary:

In the late 1970’s, Dr. Kim and his lab developed tissue culture methods for isolating and maintaining enriched populations of human oligodendrocytes derived from epilepsy surgery and post-mortem material.  These culture methods have been employed by many investigators world-wide in MS-related studies.  Using cultured human oligodendrocytes, Dr. Kim has investigated the morphological, electrophysiological, and immunological properties of oligodendrocytes in order to understand the pathogenesis of MS in which oligodendrocytes and myelin are lost.

Dr. Kim’s current research interest is centered on how to promote the proliferation of human oligodendrocyte/oligodendrocyte precursors in culture using various growth factors that include FGF, IGF, and PDGF.  If he could recruit oligodendrocytes that are remaining in the MS lesions to proliferate and remyelinate axons, it would be the definitive and best treatment for MS.

Education:
MD College of MedicineSeoul National University, Seoul, Korea
Ph.D. Kyoto University, Kyoto, Japan Pathology
Recent Publications:
  • Choi HB, Ryu JK, Kim SU, McLarnon JG. Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. J Neurosci 27:4957-4968, 2007.
  • Danks MK, K. Yoon KJ, BushRA, Remack JS, Wierdl M , Tsurkan L, Kim SU, Garcia E, Metz MZ, Najbauer J, Potter PM, Aboody KS. Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma. Cancer Res 67:22-25, 2007.
  • Dickson PV, Hamner JB, Burger RA, Garcia E, Ouma AA, Kim SU, Ng CY, Gray JT, Aboody KS, Danks MK, Davidoff AM. Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-beta and restricts tumor growth in a murine model of disseminated neuroblastoma. J Pediatr Surg 42:48-53, 2007.
  • Hara K, Matsukawa N, Yasuhara T, Xu L, Yu G, Maki M, Kawase T, Hess DC, Kim SU, Borlongan CV. Transplantation of post-mitotic human neuroteratocarcinoma-overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: in vitro evidence of expedited neuronal differentiation and GDNF secretion. J Neurosci Res 85:1240-1251, 2007.
  • Ishii J, Natsume A, Wakabayashi T, Takeuchi H, Hasegawa H, Kim SU, Yoshida J. The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress. Neurosci Lett 423:225-30, 2007.
  • Kang BS, Ahn JY, Kim MK, Kim HJ, Kang L, Lim HC, Park KS, Lee JS, Seo JS, Cha CI, Kim SU, Park YJ, Kim M. Heat shock protein 70 alters the endosome-lysosomal localization of huntingtin. Exp Mol Med 39:38-46, 2007.
  • Kim BG, Hwang TH, Kim EJ, Lee SI, Kim SU. Stem cell-based therapy in spinal cord injury. Cell Transplant 16:355-364, 2007.
  • Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, Choi KS. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 67:6314-6324, 2007.
  • Kim M, Lee ST, Chu K, Kim SU: Stem cell-based cell therapy for Huntington disease: A review. Neuropathology, 2007 Dec 5 [Epub ahead of print].
  • Kim SU. Genetically engineered human neural stem cells for brain repair in neurological diseases. Brain Dev 29:193-201, 2007.
  • Kim SY, Moon JH, Lee HG, Kim SU, Lee YB. ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion. Exp Mol Med 39:820-827, 2007.
  • Lee HJ Kim KS, Kim EJ, Lee KH, Choi HB, Park IH, Ko Y, Jeong SW, Kim SU. Brain transplantation of human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model. Stem Cells 25, 211-224, 2007.
  • Lee HJ, Kim KS, Kim EJ, Park IH, Kim SU. Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS One 1/e156:1-14, 2007.
  • Lin D, Najbauer J, Salvaterra PM, Mamelak AN, Barish ME, Garcia E, Metz MZ, Kendall SE, Bowers M, Kateb B, Kim SU, Johnson M, Aboody KS. Novel method for visualizing and modeling the spatial distribution of neural stem cells within intracranial glioma. Neuroimage 37 Suppl 1:S18-26, 2007.
  • Nagai A, Kim WK, Lee HJ, Jeong HS, Kim KS, Hong SH, Park IH, Kim SU. Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow.PLoS ONE. 2/e1272: 1-16, 2007.
  • Oh HS, Lee MC, Kim HS, Lee JS, Lee JH, Kim MK, Woo YJ, Kim JH, Kim HI, Kim SU. Pathophysiological characteristics of balloon cells in cortical dysplasia. Childs Nerv Syst, 2007 Sept 26 [Epub ahead of print].
  • Redmond DE Jr, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, Sladek JR Jr, Sidman RL, Snyder EY. From the Cover: Behavioral improvement in a primate Parkinson’s model is associated with multiple homeostatic effects of human neural stem cells. Proc Natl Acad Sci USA 104:12175-12180, 2007.
  • Ryu MY, Kim DW, Arima K, Mouradian M, Kim SU, Lee G. Localization of CKII subunits in Lewy bodies of Parkinson’s disease. J Neurol Sci, 2007 Dec 5 [Epub ahead of print].
  • Shimato S, Natsume A, Takeuchi H, Wakabayashi T, Fujii M, Ito M, Ito S, Park IH, Bang JH, Kim SU, Yoshida J. Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medulloblastoma. Gene Ther 15:1132-1142, 2007.
  • Song YG, Kim EH, Kim JY, Kim SU, Kwon TK, Yoon AR, Yun CD, Choi KS. Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and surviving. Cancer Res 67: 8274-8284, 2007.
  • Song YS, Lee HJ, Park IH, Kim WK, Ku JH, Kim SU. Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells. Int J Impot Res 19:378-385, 2007.
  • Takeuchi H, Natsume A, Wakabayashi T, Aoshima C, Shimato S, Ito M, Ishii J, Maeda Y, Hara M, Kim SU, Yoshida J. Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner. Neurosci Lett 426:69-74, 2007.
  • Ahn SM, Byun K, Cho K, Kim JY, Yoo JS, Kim D, Paek SH, Kim SU, Lee B. Human microglial cells synthesize albumin in brain. PLoS ONE 3:e2829, 2008.
  • Chu K, Jung KH, Kim SJ, Lee ST, Kim J, Park HK, Song EC, Kim SU, Kim M, Lee SK, Roh JK.Transplantation of human neural stem cells protect against ischemia in a preventive mode via hypoxia-inducible factor-1alpha stabilization in the host brain. Brain Res 1207:182-192, 2008.
  • Gutova M, Najbauer J, Frank RT, Kendall SE, Gevorgyan A, Metz MZ, Guevorkian M, Edmiston M, Zhao D, Glackin CA, Kim SU, Aboody KS. Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors. Sem Cells 26:1406-1413, 2008.
  • Hara K, Yasuhara T, Maki M, Matsukawa N, Yu G, Xu L, Kim SU, Hesse D, Borlongan C. Generating neural progeneitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke. Prog Neurobiol. 85:318-334, 2008.
  • Hwang DW, Jang SJ, Kim YH, Kim HS, Shim IK, Jeong JM, Cheung J, Lee MC, Lee SJ, Kim SU, Kim SH, Lee DS. Real time in vivo monitoring of viable stem cells implanted on biocompatible scaffolds. Eur J Nucl Med Mol Imaging DOI 10.1007, 2008.
  • Jin YW, Na Y, Lee Y, An S, Lee JE, Jung M, Kim M, Nam SY, Kim CS, Yang KH, Kim SU, Kim WK, Park WY, Yoo K, Kim CS, Kim JH. Comprehensive analysis of time and dose-dpendent patterns of gene expression in a human mesenchymal stem cell line exposed to low-dose ionizing radiation. Oncol Reports 2008; 19:135-144, 2008.
  • Kendall S, Najbauer J, Johnston HF, Metz M, Li S, Bowers M, Garcia E, Kim SU, Barish ME, Aboody KS, Glackin CA. Neural stem cell targeting of glioma is dependent on PI3K signaling. Stem Cells 26:1575-1586, 2008.
  • Kim M, Lee ST, Chu K, Kim SU. Stem cell-based cell therapy for Huntington disease: A review. Neuropathology 28:1-9, 2008.
  • Kim SS, Yoo SW, Park TS, Ahn SC, Jeong HS, Kim JW, Chang DY, Cho KG, Kim SU, Huh Y, Lee JE, Lee SY, Lee YD, Suh-Kim H. Neural induction with neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain. Stem Cells 26:2217-2228, 2008.
  • Kim SU, Nagai A, Nakagawa E, Choi HB, Bang JH, Lee HJ, Lee MA, Lee YB, Park IH. Production and characterization of immortal human neural stem cell line with multipotent differentiation property. Methods Mol Biol. 2008;438:103-21.
  • Lee ST, Chu K, Jung KH, Kim SJ, Kim DH, Kang KM, Hong NH, Kim JH, Ban JJ, Park HK, Kim SU, Park CG, Lee SK, Kim M, Roh JK. Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 131:616-629, 2008.
  • Lim HC, Lee ST, Chu K, Joo KM, Kang L, Im WS, Park JE, Kim SU, Kim M, Cha CI. Neuroprotective effect of neural stem cell-conditioned media in in vitro model of Huntington’s disease. Neurosci Lett 435:175-80, 2008.
  • Nagai A, Terashima M, Sheikh AM, Notsu Y, Shimode K, Yamaguchi S, Kobayashi S, Kim SU, Masuda J. Involvement of cystatin C in pathophysiology of CNS diseases. Front Biosci 13:3470-3479, 2008.
  • Najbauer J, Danks MK, Kim SU, Aboody KS. Neural Stem Cell-Mediated Therapy of Primary and Metastatic Solid Tumors. Progr Gene Therapy 3:1-42, 2008.
  • Oh HS, Lee MC, Kim HS, Lee JS, Lee JH, Kim MK, Woo YJ, Kim JH, Kim HI, Kim SU. Pathophysiologic characteristics of balloon cells in cortical dysplasia. Childs Nerv Syst 24:175-183, 2008.
  • Ozaki A, Nagai A, Lee YB, Myong NH, Kim SU. Expression of cytokines and cytokine receptors in human Schwann cells. Neuroreport 19:31-35, 2008.
  • Park IH, Kim MK, Kim SU. Ursodeoxycholic acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation. Biochem Biophys Res Commun 377:1025-1030, 2008.
  • Ryu MY, Kim DW, Arima K, Mouradian MM, Kim SU, Lee G. Localization of CKII beta subunits in Lewy bodies of Parkinson’s disease. J Neurol Sci 266:9-12, 2008.
  • Sheikh AM, Nagai A, Ryu JK, McLarnon JG, Kim SU, Masuda J. Lysophosphatidyl-choline induces glial cell activation: Role of rho kinase. Glia 2008 Dec 29 [Epub ahead of print].
  • Song YS, Lee HJ, Park IH, Lim IS, Ku JH, Kim SU. Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction. Brit J Urol 102:220-224, 2008.
  • Umegae N, Nagai A, Terashima M, Watanabe T, Shimode K, Kobayashi S, Masuda J, Kim SU, Yamaguchi S. Cystatin C expression in ischemic white matter lesions. Acta Neurol Scand 118:60-67, 2008.
  • Wang HK, Park UJ, Kim SY, Lee JH, Kim SU, Gwag BJ, Lee YB. Free radical production in CA1 neurons induces MIP-1alpha expression, microglia recruitment, and delayed neuronal death after transient forebrain ischemia. J Neurosci 28:1721-1727, 2008.
  • Zhao D, Najbauer J, Garcia E, Metz MZ, Gutova M, Glackin CA, Kim SU, Aboody KS.Neural stem cell tropism to glioma: Critical role of tumor hypoxia. Mol Cancer Res 2008 Dec 29, [Epub ahead of print].
  • An JH, Lee SY, Jeon JY, Cho KG, Kim, SU, Lee MA. Identification of gliotropic factors that induce human stem cell migration to malignant tumor. J Proteome Res. 2009 Jun;8(6): 2873-2881.
  • “Espinosa-Jeffrey A, Wakeman DR, Kim, SU, Snyder EY, de Vellis J. Culture system for rodent and human oligodendrocyte specification, lineage progression, and maturation.
  • Curr Protoc Stem Cell Biol. 2009 Sep;Chapter 2:Unit 2D.4.”
  • Frank RT, Edmiston M, Kendall SE, Najbauer J, Cheung CW, Kassa T, Metz MZ, Kim, SU, Glackin CA, Wu AM, Yazaki PJ, Aboody KS. Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies. PLoS One. 2009 Dec 15;4(12):e8314.
  • Gutova M, Najbauer J, Chen MY, Kim, SU, Aboody KS. Therapeutic Targeting of Melanoma Cells Using Neural Stem Cells Expressing Carboxylesterase, a CPT-11 Activating Enzyme. Curr Stem Cell Res Ther. 2009 Dec 2. [Epub ahead of print].
  • Hwang DH, Kim BG, Kim EJ, Lee SI, Joo IS, Suh-Kim H, Sohn S, Kim, SU. Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury. BMC Neurosci. 2009 Sep 22;10:117.
  • Hwang DH, Kim KS, Lee HJ, seok JI, Kim BG, Joo IS, Kim SU. Intrathecal transplantation of human neural stem cells over-expressing VEGF provides behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Gene Ther, in press.
  • Hwang DH, Lee HJ, Park IH, Seok JI, Kim BG, Joo IS, Kim, SU. Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Gene Ther. 2009 Oct; 16(10):1234-1244.
  • Ito S, Natsume A, Shimato S, Ohno M, Kato T, Chansakul P, Wakabayashi T, Kim, SU. Human neural stem cells transduced with IFN-beta and cytosine deaminase genes intensify bystander effect in experimental glioma. Cancer Gene Ther. 2009 Nov 6. [Epub ahead of print].
  • Joo K, Park IH, Shin JY, Jin J, Kang BG, Kim SY, Kim MH, Kim SU, Nam D. Human neural stem cells target and deliver therapeutic genes to breast cancer brain metastasis. Mol Ther, 2009 Jan 6 [Epub ahead of print].
  • Joo KM, Park IH, Shin JY, Jin J, Kang BG, Kim MH, Lee SJ, Jo MY, Kim, SU, Nam DH. Human neural stem cells can target and deliver therapeutic genes to breast cancer brain metastases. Mol Ther. 2009 Mar;17(3):570-575.
  • Kim BG, Hwang DH, Lee SI, Kim SU. Ex vivo delivery using neural stem cells enhances proliferation of glail progenitors, angiogenesis and tissue sparing after spinal cord injury. PLoS One, in press (02-24-09).
  • Kim HM, Hwang DH, Lee JE, Kim, SU, Kim BG. Ex vivo VEGF delivery by neural stem cells enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord injury. PLoS One. 2009;4(3):e4987. Epub 2009 Mar 25.
  • Kim JY, Kim EH, Kim, SU, Kwon TK, Choi KS. Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin down regulation. Carcinogenesis. 2009 Nov 25. [Epub ahead of print].
  • Kim SU, de Vellis J. Stem cell-based cell therapy for neurological diseases: A review. J Neurosci Res, in press.
  • Kim SY, Cho HS, Yang SH, Shin JY, Kim JS, Lee ST, Chu K, Roh JK, Kim SU, Park CG. Soluble mediators from human neural stem cells play a critical role in suppression of T cell activation and proliferation. J Neurosci Res, in press.
  • Kim SY, Cho HS, Yang SH, Shin JY, Kim JS, Lee ST, Chu K, Roh JK, Kim, SU, Park CG.  Soluble mediators from human neural stem cells play a critical role in suppression of T-cell activation and proliferation. J Neurosci Res. 2009 Aug 1;87(10):2264-2272.
  • “Kim, SU, de Vellis J. Stem cell-based cell therapy in neurological diseases: a review.
  • J Neurosci Res. 2009 Aug 1;87(10):2183-2200.”
  • Lee DH, Ahn Y, Kim, SU, Wang KC, Cho BK, Phi JH, Park IH, Black PM, Carroll RS, Lee J, Kim SK. Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. Clin Cancer Res. 2009 Aug 1;15(15):4925-4934. Epub 2009 Jul 28.
  • Lee HJ, Kim MK, Kim HJ, Kim, SU. Human neural stem cells genetically modified to overexpress Akt1 provide neuroprotection and functional improvement in mouse stroke model. PLoS One. 2009;4(5):e5586. Epub 2009 May 18.
  • Lee HJ, Park IH, Kim HJ, Kim SU. Human neural stem cells overexpressing glial cell line derived neurotrophic factor (GDNF) promote functional recovery and neuroprotection in experimental cerebral hemorrhage. Gene Ther, in press.
  • Lee HJ, Park IH, Kim HJ, Kim, SU. Human neural stem cells overexpressing glial cell line-derived neurotrophic factor in experimental cerebral hemorrhage. Gene Ther. 2009 Sep;16(9):1066-76.
  • Lee SH, Chung YN, Kim YH, Kim YJ, Park JP, Kwon DK, Kwon OS, Heo JH, Kim YH, Ryu S, Kang HJ, Paek SH, Wang KC, Kim, SU, Yoon BW. Effects of human neural stem cell transplantation in canine spinal cord hemisection. Neurol Res. 2009 Nov;31(9):996-1002.
  • Lee SI, Kim BG, Hwang DH, Kim HM, Kim, SU. Overexpression of Bcl-XL in human neural stem cells promotes graft survival and functional recovery following transplantation in spinal cord injury. J Neurosci Res. 2009 Nov 1;87(14):3186-3197.
  • Narantuya D, Nagai A, Sheikh AM, Wakabayashi K, Shiota Y, Watanabe T, Masuda J, Kobayashi S, Kim, SU, Yamaguchi S. Microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition. Brain Res. 2009 Dec 23. [Epub ahead of print].
  • Obayashi S, Tabunoki H, Kim SU, Satoh JI. Gene expression profiling of human neural progenitor cells following the serum-induced astrocyte differentiation. 2009 Jan 6, [Epub ahead of print].
  • Obayashi S, Tabunoki H, Kim, SU, Satoh J. Gene expression profiling of human neural progenitor cells following the serum-induced astrocyte differentiation. Cell Mol Neurobiol. 2009 May;29(3):423-438.
  • Park MH, Lee YK, Lee YH, Kim YB, Yun YW, Nam SY, Hwang SJ, Han SB, Kim, SU, Hong JT. Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation. Exp Cell Res. 2009 Oct 1;315(16):2715-2726.
  • Satoh JI, Obayashi S, Tabunoki H, Wakana T, Kim, SU. Stable Expression of Neurogenin 1 Induces LGR5, a Novel Stem Cell Marker, in an Immortalized Human Neural Stem Cell Line HB1.F3. Cell Mol Neurobiol. 2009 Oct 8. [Epub ahead of print].
  • Schmidt NO, Koeder D, Messing M, Mueller FJ, Aboody KS, Kim, SU, Black PM, Carroll RS, Westphal M, Lamszus K. Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche. Brain Res. 2009 May 1;1268:24-37. Epub 2009 Mar 10.
  • Sheikh AM, Nagai A, Ryu JK, McLarnon JG, Kim, SU, Masuda J. Lysophosphatidylcholine induces glial cell activation: role of rho kinase. Glia. 2009 Jun;57(8):898-907.
  • Sims TL Jr, Hamner JB, Bush RA, Fischer PE, Kim, SU, Aboody KS, McCarville B, Danks MK, Davidoff AM. Neural progenitor cell-mediated delivery of osteoprotegerin limits disease progression in a preclinical model of neuroblastoma bone metastasis. J Pediatr Surg. 2009 Jan;44(1):204-210; discussion 210-211.
  • Song M, Kim Y, Kim Y, Ryu S, Song I, Kim, SU, Yoon BW. MRI tracking of intravenously transplanted human neural stem cells in rat focal ischemia model. Neurosci Res. 2009 Jun;64(2):235-239.
  • Thu MS, Najbauer J, Kendall SE, Harutyunyan I, Sangalang N, Gutova M, Metz MZ, Garcia E, Frank RT, Kim, SU, Moats RA, Aboody KS. Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model. PLoS One. 2009 Sep 29;4(9):e7218.
  • Wakabayashi K, Nagai A, Sheikh AM, Shiota Y, Narantuya D, Watanabe T, Masuda J, Kobayashi S, Kim, SU, Yamaguchi S. Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. J Neurosci Res. 2009 Nov 2. [Epub ahead of print].
  • Yuki K, Natsume A, Yokoyama H, Kondo Y, Ohno M, Kato T, Chansakul P, Ito M, Kim, SU, Wakabayashi T. Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling. Cancer Lett. 2009 Oct 18;284(1):71-79.