Position:
Adjunct Professor
Division:
Neurology
Research Interests:

Application of PET to Neurology, Radionuclide production; Gas targets; Fast chemical separations; PET tomograph physics; Astatine chemistry; Isotope separators; Automation.

Education:
BS St. Francis College, PA Chemistry
MA College of William & Mary, VA Nuclear Chemistry
Ph.D. Clark University, MA Nuclear Spectroscopy
Recent Publications:
  • DJ Doudet, P Rosa-Netto, TJ Ruth, S Jivan, P Cumming. Mapping of markers for monoaminergic neurons of normal and MPTP poisoned rhesus monkeys: A multi-tracer PET study. Neuroimage. 30: 26-35 (2006).
  • Doudet DJ, Rosa-Neto P, Munk OL, Ruth TJ, Jivan S, Cumming P. Effect of age on markers for monoaminergic neurons of normal and MPTP-lesioned rhesus monkeys: A multi-tracer PET study. Neuroimage. 2006; 30:26-35.
  • Doudet DJ, Ruth TJ, Holden JE. Sequential versus nonsequential measurement of density and affinity of dopamine D2 receptors with [11C]raclopride: 2: effects of DAT inhibitors. J Cereb Blood Flow Metab. 2006; 26:28-37.
  • EWK Young, K Buckley DM Martinez, S Jivan, JA Olson, V Sossi, TJ Ruth “Sedimentation of Papermaking Fibres”, Am Inst Chem Eng J. 52(8): ?-? 2006.
  • Guo, B., Liu, W.P., Trinczek, M., Lapi, S, Ames, F., Buckley, K.R., D’Auria, J.M., Jayamanna, K., Ruiz, C., Ruth, T.J. Production of intense radioactive beams using low energy protons. High Energy Physics and Nuclear Physics (Chinese edition) 30: 679-679 (2006).
  • Koochesfahani KM, de la Fuente-Fernández R, Sossi V, Schulzer M, Yatham LN, Ruth TJ, Stoessl AJ (2006).  Oral methylphenidate fails to elicit significant changes in extracellular dopamine levels in Parkinson’s disease (PD) patients: positron emission tomographic studies (PET). Movement Disorders 21: 970-5.
  • M. Trinczek, S. Lapi, B. Guo, F. Ames, K.R. Buckley, J.M. D’Auria, K. Jayamanna, W.P. Liu, C. Ruiz, T.J. Ruth. Production of intense radioactive beams at ISAC using low-energy protons. Can. J. Phys., 84: 325- 333 (2006).
  • S Heath, K Buckley, DM Martinez, S Lapi, JA Olson, TJ Ruth. Some Observations of the Flow of a Semi-Dilute Fibre Suspension Through a Sudden Expansion Using Positron Emission Tomography. Amer. Inst. Chem. Eng. accepted December 2006.
  • S-J Kim, DJ Doudet, AR Studenov, C Nian, TJ Ruth, SS Gambhir, CHS McIntosh. Quantitative micro positron emission tomography (PET) imaging for the in vivo determination of pancreatic islet graft survival. Nat. Med. 12:1423-8 (2006).
  • V Sossi, S McCormick, R Kornelsen, EM Strome, TJ Ruth, DJ Doudet. TJ Ruth. Effect of anesthesia on DTBZ and MP binding as evaluated by a Concord-CTI microPET imaging and post mortem measures. Mol. Imaging Biol. In press, 2006.
  • CL Ferreira, S Lapi, J Steele, DE Green, TJ Ruth, MJ Adam, C Orvig. Cobalt-55 Complexes with Pendant Carbohydrates as Potential PET Imaging Agents. Appl. Radiat. Isot. 65: 1303-1308 (2007).
  • DTT Yapp, TJ Ruth, MJ Adam, D Green, M Gleave. Non-invasive evaluation of tumor model for prostate cancer with 18F-EF5 and positron emission tomography. Brit. J. Urology International. 99:1154-60 (2007).
  • JT Wong, PTW Kim, AL-F Mui, ST Chung, V Sossi, D Doudet, D Green, T Ruth, R Parsons, CB Verchere, CJ Ong. Pten haploinsufficiency promotes insulin hypersensitivity. Diabetologia, 50:395-403. (2007).
  • S Lapi, J Wilson, S McQuarrie, J Publicover, M Schueller, D Schyler, J Ressler, TJ Ruth. Measurement of cross sections production of 181-186Re isotopes from proton bombardment of natural tungsten. Appl. Radiat. Isotopes. 65:345-9 2007.
  • V Sossi, JE Holden, G Topping, M-L Camborde, R Kornelsen, S McCormick, J Greene, A Studenov, TJ Ruth, DJ Doudet. In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD. JCBF 27:1407-15 (2007).
  • V Sossi, R de la Fuente-Fernández, M Schulzer, A Troiano, TJ Ruth, AJ Stoessl. Dopamine transporter relation to dopamine turnover in Parkinson’s: a PET study. Ann. Neur. (2007); 62:468-74.
  • AL Annett, S Lapi, TJ Ruth, MT Maldonado. The effects of Cu and Fe availability on the growth and Cu:C ratios of marine Diatoms. Limnology and Oceanography, 53: 2451–2461 (2008).
  • Harwig CW, Ting R, Adam MJ, Ruth TJ, Perrin DM. Synthesis and characterization of 2,6-difluoro-4-carboxyphenylboronic acid and a biotin derivative thereof as captors of anionic aqueous [18F]-fluoride to prepare an [18F]-labeled aryltrifluoroborates with high kinetic stability. Tetrahedron Letters, 49: 3152-3156 (2008).
  • JAH Inkster, B Guérin, TJ Ruth, MJ Adam. Radiosynthesis and bioconjugation of [18F]FPy5yne, a prosthetic group for the 18F labeling of bioactive peptides. J Lab Comp. Radiopharm.  51: 444-452 (2008).
  • R. Nandhagopal, E Mak, M Schulzer, J McKenzie, S McCormick, V Sossi,  TJ Ruth, A Strongosky, MJ. Farrer, ZK Wszolek, AJ Stoessl. Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study. Neurology. 71:1790-5. (2008).
  • Ting R, Harwig C, auf dem Keller U, McCormick S, Austin P, Overall CM, Adam MJ, Ruth TJ, Perrin DM. Toward [18F]-labeled aryltrifluoroborate radiotracers: in vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice. JACS, 130:12045-55 (2008).
  • Ting R, Harwig C, Lo J, Li Y, Adam MJ, Ruth T, Perrin D. Substituent Effects on Aryltrifluoroborate Solvolysis in Water: Implications for Suzuki-Miyaura Coupling and the Design of Stable 18F-Labeled Aryltrifluoroborates for Use in PET Imaging.  J Organic Chem 73:4662-70 (2008).
  • Ting R, Lo J, Adam MJ, Ruth TJ, Perrin DM. Synthesis, purification, and aqueous stability of a fluorescent [18F]-labeled aryltrifluoroborate. J Fluorine Chem, 129: 349-358. (2008).
  • Troiano AR, de la Fuente-Fernandez R, Sossi V, Schulzer M, Mak E, Ruth TJ, Stoessl AJ (2008). PET demonstrates reduced dopamine transporter expression in PD with dyskinesias. Neurology. 2008 Nov 19. [Epub ahead of print].
  • Ruth TJ. Accelerating production of medical isotopes. Nature 457:536-537 (Invited Essay – 29 January 2009).
  • de la Fuente-Fernández R, Sossi V, McCormick S, Schulzer M, Ruth TJ, Stoessl AJ. Visualizing vesicular dopamine dynamics in Parkinson’s disease.  Synapse 63:713-716. (2009.).
  • Inkster JAH, Adam MJ, Storr T, Ruth TJ. Labelling of an Antisense Oligonucleotide with [18F]FPy5yne. Nucleosides, Nucleotides and Nucleic Acids, 28: 1131-1143. 2009.
  • Nandhagopal R, Kuramoto L, Schulzer M, Mak E, Cragg J, Lee CS, McKenzie J, McCormick S, Samii A, Troiano A, Ruth, TJ, Sossi V, de la Fuente-Fernandez R, Calne DB, Stoessl AJ (2009). Longitudinal progression of sporadic Parkinson’s disease: a multi-tracer positron emission tomography study. Brain.132: 2970-9.
  • Semeniuk DM, Cullen JT, Gagnon K, Ruth TJ, Maldonado MT. Plankton copper requirements and uptake in the sub-Arctic NE Pacific Ocean. Deep Sea Research I. 56, 1130-1142 (2009).
  • Sossi V, Dinelle K, de la Fuente-Fernandez R, Stoessl AJ,  Topping GJ, Holden JE, Schulzer M, Ruth TJ, Doudet D. Dopamine transporter relation to levodopa-derived synaptic dopamine in a rat model of Parkinson’s: an in-vivo imaging study. J. Neurochemistry. 109:85-92 (2009).
  • Troiano AR, de la Fuente-Fernandez R, Sossi V, Schulzer M, Mak E, Ruth, TJ, Stoessl AJ (2009). PET demonstrates reduced dopamine transporter expression in PD with dyskinesias. Neurology. 72: 1211-1216.
  • auf dem Keller U, Bellac C, Li Y, Lou Y, Lange P, Ting R, Harwig C, Kappelhoff R, Dedhar S, Adam M, Ruth R, Bernard F, Perrin D,  Overall C. [18F]-Marimastat-aryltrifluoroborate: A non-covalent peptidic metalloproteinase inhibitor for in vivo PET imaging in cancer . J Cancer Res. In press, June 2010.
  • de la Fuente-Fernandez R, Schulzer M, Kuramoto L, Cragg J, Nandhagopal R, Au WL, Mak E, McKenzie J, McCormick S, Sossi V, Ruth TJ, Lee CS, Calne DB, Stoessl AJ (2010). Age specific patterns of progression of nigrostriatal dysfunction in Parkinson’s disease. Ann Neurol. 2010 Oct 28. doi: 10.1002/ana.22284. [Epub ahead of print].
  • Gagnon K, Jensen M, McQuarrie, Publicover JG, Lapi SE, Ruth TJ. A new and simple calibration independent method for measuring the beam energy of a cyclotron. Appl. Radiat. Isotopes. In Press Sept. 2010.
  • Guo J, Annett AL, Taylor RL, Lapi S, Ruth TJ, Maldonado MT. Copper-uptake kinetics of coastal and oceanic diatoms, J. Phycol. 46, 1218–1228 (2010).
  • Lidstone S, Schulzer M, Mak E, Sossi V, Ruth TJ, Dinelle K, de la Fuente-Fernandez R, Stoessl AJ. Effects of Expectation on Placebo-Induced Dopamine Release in Parkinson Disease Arch. Gen. Psych. 2010; 67:857-865.
  • Powe J, Worsley D, Ruth TJ. Radioisotope Shortages in Nuclear Medicine: How we got there and developing solutions. Can. Assoc. Radiologists Journal. 61: 19-22 (2010).
  • Sossi V, de la Fuente-Fernandez R, Nandhagopal R, Schulzer M, McKenzie J, Ruth TJ, Aasly JO, Farrer MJ, Wszolek ZK, Stoessl AJ (2010). Dopamine turnover increases in asymptomatic LRRK2 mutation carriers. Movement Disorders 15 2717-2723.
  • Troiano AR, Schulzer M, de la Fuente-Fernandez R, Mak E, McKenzie J, Sossi V, McCormick S,  Ruth TJ, Stoessl AJ. Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function. Synapse. 2010; 64:146-51.
  • Yahtam L, Lam R, Erez J, Sossi V, Imperial M, Santana M, Ruth TJ, Liddle P. Brain serotonin-2 receptors in acute mania. Br J Psychiatry. 2010;196:47-51.
  • Yatham LN, Liddle PF, Lam RW,  Zis AP,  Stoessl JA, Sossi V,  Adam MJ, Ruth TJ. Decrease in Brain 5-HT2 Receptors with Electroconvulsive therapy in Patients with Major Depression. Brit. J. Psych. 196: 474-479 (2010).
  • Yatham LN, Liddle PF, Lam RW, Zis AP, Stoessl AJ, Sossi V, Adam MJ, Ruth TJ (2010). Effect of electroconvulsive therapy on brain 5HT2 receptors in major depression. Br J Psychiatry 196: 474-479.