Position:
Assistant Professor
Canada Research Chair in Precision Cardiovascular Disease Prevention
Division:
General Internal Medicine
Research Interests:
  • Inherited Dyslipidemias
  • Genetics of Premature Cardiovascular Disease
  • Pharmacogenomics of adverse Drug reactions
Education:
University of British Columbia, 2008, MD
University of British Columbia, 2008, PhD
Clinician Investigator Program, Singapore, 2015
Recent Publications:

Selected Publications

1: Trinder M, Boyd JH, Brunham LR. Molecular regulation of plasma lipid levels during systemic inflammation and sepsis. Curr Opin Lipidol. 2019 Apr; 30(2):108-116. doi: 10.1097/MOL.0000000000000577. PubMed PMID: 30649022.

2: Brunham LR, Ruel I, Aljenedil S, Rivière JB, Baass A, Tu JV, Mancini GBJ, Raggi P, Gupta M, Couture P, Pearson GJ, Bergeron J, Francis GA, McCrindle BW, Morrison K, St-Pierre J, Henderson M, Hegele RA, Genest J, Goguen J, Gaudet D, Paré G, Romney J, Ransom T, Bernard S, Katz P, Joy TR, Bewick D, Brophy J. Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia: Update 2018. Can J Cardiol. 2018 Dec;34(12):1553-1563. doi: 10.1016/j.cjca.2018.09.005. PubMed PMID: 30527143.

3: Genga KR, Trinder M, Kong HJ, Li X, Leung AKK, Shimada T, Walley KR, Russell JA, Francis GA, Brunham LR, Boyd JH. CETP genetic variant rs1800777 (allele A) is associated with abnormally low HDL-C levels and increased risk of AKI during sepsis. Sci Rep. 2018 Nov 13;8(1):16764. doi: 10.1038/s41598-018-35261-2. PubMed  PMID: 30425299; PubMed Central PMCID: PMC6233165.

4: Trinder M, Genga KR, Kong HJ, Blauw LL, Lo C, Li X, Cirstea M, Wang Y, Rensen PCN, Russell JA, Walley KR, Boyd JH, Brunham LR. Cholesteryl Ester Transfer Protein Influences High-Density Lipoprotein Levels and Survival in Sepsis. Am J Respir Crit Care Med. 2018 Oct 15. doi: 10.1164/rccm.201806-1157OC. [Epub ahead of print] PubMed PMID: 30321485.

5: Brunham LR, Ruel I, Khoury E, Hegele RA, Couture P, Bergeron J, Baass A, Dufour R, Francis GA, Cermakova L, Mancini GBJ, Brophy JM, Brisson D, Gaudet D, Genest J. Familial hypercholesterolemia in Canada: Initial results from the FH Canada national registry. Atherosclerosis. 2018 Oct;277:419-424. doi: 10.1016/j.atherosclerosis.2018.05.040. PubMed PMID: 30270080.

6: Razek O, Cermakova L, Armani H, Lee T, Francis GA, Mancini GBJ, Frohlich J, Brunham LR. Attainment of Recommended Lipid Targets in Patients With Familial Hypercholesterolemia: Real-World Experience With PCSK9 Inhibitors. Can J Cardiol. 2018 Aug;34(8):1004-1009. doi: 10.1016/j.cjca.2018.04.014. Epub 2018 Apr 20. PubMed PMID: 30056842.

7: Christidi E, Huang HM, Brunham LR. CRISPR/Cas9-mediated genome editing in human stem cell-derived cardiomyocytes: Applications for cardiovascular disease modelling and cardiotoxicity screening. Drug Discov Today Technol. 2018 Aug;28:13-21. doi: 10.1016/j.ddtec.2018.06.002. Epub 2018 Jun 25. Review. PubMed PMID: 30205876.

8: Brunham LR, Baker S, Mammen A, Mancini GBJ, Rosenson RS. Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence. Cardiovasc Res. 2018 Jul 1;114(8):1073-1081. doi: 10.1093/cvr/cvy119. PubMed PMID: 29878063; PubMed Central PMCID: PMC6014181.

9: Brunham LR, Lynch K, English A, Sutherland R, Weng J, Cho R, Wong GC, Anis AH, Francis GA, Khan NA, McManus B, Wood D, Walley KR, Leipsic J, Humphries KH, Hoens A, Krahn AD, John Mancini GB, Pimstone S. The design and rationale of SAVE BC: The Study to Avoid Cardio Vascular Events in British Columbia. Clin Cardiol. 2018  Jul;41(7):888-895. doi: 10.1002/clc.22959. Epub 2018 Jun 11. PubMed PMID: 29635745.

10: Abdel-Razek O, Sadananda SN, Li X, Cermakova L, Frohlich J, Brunham LR. Increased prevalence of clinical and subclinical atherosclerosis in patients with damaging mutations in ABCA1 or APOA1. J Clin Lipidol. 2018 Jan – Feb;12(1):116-121. doi: 10.1016/j.jacl.2017.10.010. Epub 2017 Nov 10. PubMed PMID: 29150341.

11: Saw WY, Tantoso E, Begum H, Zhou L, Zou R, He C, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY. Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study. Nat Commun. 2017 Sep 21;8 (1) :653. doi: 10.1038/s41467-017-00413-x. PubMed PMID: 28935855; PubMed Central PMCID: PMC5608948.

12: Rosenson RS, Baker S, Banach M, Borow KM, Braun LT, Bruckert E, Brunham LR, Catapano AL, Elam MB, Mancini GBJ, Moriarty PM, Morris PB, Muntner P, Ray KK, Stroes ES, Taylor BA, Taylor VH, Watts GF, Thompson PD. Optimizing Cholesterol Treatment in Patients With Muscle Complaints. J Am Coll Cardiol. 2017 Sep 5;70(10):1290-1301. doi: 10.1016/j.jacc.2017.07.752. Review. PubMed PMID: 28859793.

13: Brunham LR, Cermakova L, Lee T, Priecelova I, Alloul K, de Chantal M, Francis GA, Frohlich J. Contemporary Trends in the Management and Outcomes of Patients With Familial Hypercholesterolemia in Canada: A Prospective Observational Study. Can J Cardiol. 2017 Mar;33(3):385-392. doi: 10.1016/j.cjca.2016.08.016. Epub 2016 Sep 3. PubMed PMID: 27931859.

14: Maillet A, Tan K, Chai X, Sadananda SN, Mehta A, Ooi J, Hayden MR, Pouladi MA, Ghosh S, Shim W, Brunham LR. Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes. Sci Rep. 2016 May 4;6:25333. doi: 10.1038/srep25333. PubMed PMID: 27142468; PubMed Central PMCID: PMC4855185.

15: Sadananda SN, Foo JN, Toh MT, Cermakova L, Trigueros-Motos L, Chan T, Liany H, Collins JA, Gerami S, Singaraja RR, Hayden MR, Francis GA, Frohlich J, Khor CC, Brunham LR. Targeted next-generation sequencing to diagnose disorders of HDL cholesterol. J Lipid Res. 2015 Oct;56(10):1993-2001. doi: 10.1194/jlr.P058891. Epub 2015 Aug 8. PubMed PMID: 26255038; PubMed Central PMCID: PMC4583092.

16: Aminkeng F, Bhavsar AP, Visscher H, Rassekh SR, Li Y, Lee JW, Brunham LR, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Amstutz U, Rieder MJ, Bernstein D, Carleton BC, Hayden MR, Ross CJ; Canadian Pharmacogenomics Network for Drug Safety Consortium. A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer. Nat Genet. 2015 Sep;47(9):1079-84. doi: 10.1038/ng.3374. Epub 2015 Aug 3. PubMed PMID: 26237429;  PubMed Central PMCID: PMC4552570.

17: Brunham LR, Lansberg PJ, Zhang L, Miao F, Carter C, Hovingh GK, Visscher H, Jukema JW, Stalenhoef AF, Ross CJ, Carleton BC, Kastelein JJ, Hayden MR. Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin. Pharmacogenomics J. 2012 Jun;12(3):233-7. doi: 10.1038/tpj.2010.92. Epub 2011 Jan 18. PubMed PMID: 21243006.

18: Brunham LR, Hayden MR. Medicine. Whole-genome sequencing: the new standard of care? Science. 2012 Jun 1;336(6085):1112-3. doi: 10.1126/science.1220967. PubMed PMID: 22654044.

19: Brunham LR, Kruit JK, Pape TD, Timmins JM, Reuwer AQ, Vasanji Z, Marsh BJ,Rodrigues B, Johnson JD, Parks JS, Verchere CB, Hayden MR. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat Med. 2007 Mar;13(3):340-7. Epub 2007 Feb 18. PubMed PMID: 17322896.

20: Brunham LR, Kruit JK, Pape TD, Parks JS, Kuipers F, Hayden MR.
Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res. 2006 Sep 29;99(7):672-4. Epub 2006 Aug 31. PubMed PMID: 16946132.

21: Brunham LR, Kruit JK, Iqbal J, Fievet C, Timmins JM, Pape TD, Coburn BA, Bissada N, Staels B, Groen AK, Hussain MM, Parks JS, Kuipers F, Hayden MR. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest. 2006 Apr;116(4):1052-62. Epub 2006 Mar 16. PubMed PMID: 16543947; PubMed Central PMCID: PMC1401485.

22: Brunham LR, Singaraja RR, Pape TD, Kejariwal A, Thomas PD, Hayden MR. Accurate prediction of the functional significance of single nucleotide
polymorphisms and mutations in the ABCA1 gene. PLoS Genet. 2005 Dec;1(6):e83. Epub 2005 Dec 30. PubMed PMID: 16429166; PubMed Central PMCID: PMC1342637.

Awards & Recognition:
  • CIHR New Investigator Award, 2017
  • Michael Smith Foundation for Health Research Scholar Award, 2017
  • Heart and Stroke Foundation National New Investigator Award, 2016
  • Canada’s Top 40 under 40, 2017
  • CIHR
  • Genome BC
  • CFI