Position:
Clinical Associate Professor
Division:
Critical Care Medicine
Education:
Chem/Biochem – undergrad University of Toronto
MD University of Toronto
Recent Publications:
  • Dodek PM, Norena M, Wong H, Keenan S, Martin C. Assessing the influence of intensive care unit organizational factors on outcomes in Canada: Is there residual confounding? J Intensive Care Med 2015; 30:413-419
  • Sood MM, Shafer LA, Ho J, Reslerova M, Martinka G, Keenan S, Dial S, Wood G, Rigatto C, Kumar A; Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group. Early reversible acute kidney injury is associated with improved survival in septic shock. J Crit Care 2014; 29:711-717
  • Sood M, Mandelzweig K, Rigatto C, Tangri N, Komenda P, Martinka G, Arabi Y, Keenan S, Kumar A; Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group. Non-pulmonary infections but not specific pathogens are associated withincreased risk of AKI in septic shock. Intensive Care Med 2014; 40:1080-1088
  • Burry L, Cook D, Herridge M, Devlin JM, Fergusson D, Meade M, Steinberg M, Skrobnik Y, OlafsonK, Burns K, Dodek P, GrantonJ, Ferguson N, Jacka M, Tanios M, Fowler R, Reynolds S, Keenan S, Mallick R, Mehta S; SLEAP Investigators and the Canadian Critical Care Trials Group. Recall of ICU stay in patients managed with a sedation protocol or a sedation protocol with daily interruption. Crit Care Med 2015; 43:218-2190
  • Mehta S, Cook D, Devlin JW, Skrobik Y, Meade M, Fergusson D, Herridge M, Steinbery M, Granton J, Ferguson N, Tanios , Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Mallick R, Reynolds S, Keenan S, Burry L; SLEAP Investigators: Canadian Critical Care Trials Group. Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. Crit Care Med 2015;43:557-566
  • Cook DJ, Ferguson ND, Hand L, Austin P, Zhou Q, Adhikari NK, Danesh V, Arabi Y, Matte AL, Clarke FE,Mehta S, Smith O, Wise MP, Friedrich JO, Keenan SP, Hanna S, Meade MO; OSCILLation for ARDS Treated Early Investigators; Canadian Critical Care Trials Group. Coenrollment in a randomized trial of High-frequency oscillation: prevalence, patterns, predictors and outcomes. Crit Care Med 2015;43:328-338
  • Digby GC, Keenan SP, Parker CM, Sinuff T, Burns KE, Mehta S, Ronco JJ, Kutsogiannis DJ, Rose L, Ayas NT, Berthiaume LR, D’Arsigny CL, Stollery DE, and Muscedere J. Non-Invasive Ventilation Practice Patterns in Canadian Tertiary Care Centers: A Descriptive Analysis. Canadian Respiratory Journal. 2015. [in press].
  • Boyce K, Dillon EC, Perrott J, Malyuk DL, Mabasa VH, Attfield E, McCormack G, Keenan S. Drug-Use Evaluation Comparing Dexmedetomidine Use at 3 Health Authority Sites Relative to Manufacturer’s Recommended Directions (DECODE Study). Can J Hosp Pharm 2014; 67(5):379-386
  • Dodek PM, Wong H, Norena M, Ayas N, Reynolds SR, Keenan SP, Hamric A, Rodney P, Stewart M, Alden L. Moral Distress in ICU Professionals is Associated with Profession, Age, and Years of Experience Journal of J Crit Care. 2016 Feb;31(1):178-82. doi: 10.1016/j.jcrc.2015.10.011. Epub 2015 Oct 20.
  • Rose L, Burry L, Mallick R, Luk E, Cook D, Fergusson D, Dodek P, Burns K, Granton J, Ferguson N, Devlin JW, Steinberg M, Keenan S, Reynolds S, Tanios M, Fowler RA, Jacka M, Olafson K, Skrobik Y, Mehta S. Prevalence, risk factors, and outcomes associated with physical restraint use in mechanically ventilated adults. J Crit Care. 2016 Feb;31(1):31-5. doi: 10.1016/j.jcrc.2015.09.011. Epub 2015 Sep 25.
  • Digby GC, Keenan SP, Parker CM, Sinuff T, Burns KE, Mehta S, Ronco JJ, Kutsogiannis DJ, Rose L, Ayas NT, Berthiaume LR, D’Arsigny CL, Stollery DE, Muscedere J.
    Noninvasive ventilation practice patterns for acute respiratory failure in Canadian tertiary care centres: A descriptive analysis. Can Respir J. 2015 Nov-Dec;22(6):331-40. Epub 2015 Oct 15
  • Burry L, Cook D, Herridge M, Devlin JW, Fergusson D, Meade M, Steinberg M, Skrobik Y, Olafson K, Burns K, Dodek P, Granton J, Ferguson N, Jacka M, Tanios M, Fowler R, Reynolds S, Keenan S, Mallick R, Mehta S; SLEAP Investigators; Canadian Critical Care Trials Group. Recall of ICU Stay in Patients Managed With a Sedation Protocol or a Sedation Protocol With Daily Interruption. Crit Care Med. 2015 Oct;43(10):2180-90. doi: 10.1097/CCM.0000000000001196.
  • Henrich NJ, Dodek PM, Alden L, Keenan SP, Reynolds S, Rodney P.Causes of moral distress in the intensive care unit: A qualitative study.J Crit Care. 2016 Oct;35:57-62. doi: 10.1016/j.jcrc.2016.04.033. Epub 2016 May 12
  • Amaral AC, Fowler RA, Pinto R, Rubenfeld GD, Ellis P, Bookatz B, Marshall JC, Martinka G, Keenan S, Laporta D, Roberts D, Kumar A; Cooperative Antimicrobial Therapy of Septic Shock Database Research Group. Patient and Organizational Factors Associated With Delays in Antimicrobial Therapy for Septic Shock. Crit Care Med. 2016 Dec;44(12):2145-2153.
  • D’Aragon F, Dhanani S, Lamontagne F, Cook DJ, Burns K, Akhtar A, Chassé M, Frenette AJ, Keenan S, Lize JF, Kutsogiannis DJ, Kramer A, Hand LE, Arseneau E, Masse MH, Ribic C, Ball I, Baker A, Boyd G, Rochwerg B, Healey A, Hanna S, Guyatt GH, Meade MO; Canadian Critical Care Trials Group and the Canadian National Transplant Research Program.Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors. BMJ Open. 2017 Sep 28;7(9):e018858. doi: 10.1136/bmjopen-2017-018858
  • Rochwerg B, Brochard L, Elliott MW, Hess D, Hill NS, Nava S, Navalesi P Members Of The Steering Committee, Antonelli M, Brozek J, Conti G, Ferrer M, Guntupalli K, Jaber S, Keenan S, Mancebo J, Mehta S, Raoof S Members Of The Task Force. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure.Eur Respir J. 2017 Aug 31;50(2). pii: 1602426. doi: 10.1183/13993003.02426-2016. Print 2017 Aug
    Henrich NJ, Dodek PM, Gladstone E, Alden L, Keenan SP, Reynolds S, Rodney
  • P.Consequences of Moral Distress in the Intensive Care Unit: A Qualitative Study. Am J Crit Care. 2017 Jul;26(4):e48-e57. doi: 10.4037/ajcc2017
  • Kok B, Karvellas CJ, Abraldes JG, Jalan R, Sundaram V, Gurka D, Keenan S, Kumar A, Martinka G, Bookatz B, Wood G, Kumar A; Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Research Group. The impact of obesity in cirrhotic patients with septic shock: A retrospective cohort study. Liver Int. 2018 Jul;38(7):1230-1241. doi: 10.1111/liv.13648. Epub 2017 Dec 18. PMID:9194916
  • Belway D, Henderson W, Keenan SP, Levy A, Dodek PM.  The Effect of Pretransport Stabilization and Specialization of Transport Personnel on Outcome of Critically Ill Patients Transferred Between Hospitals: A Systematic Review of the Literature.  J Crit Care 2006; 21:8-17.
  • Norena M, Wong H, Thompson WD, Keenan SP, Dodek PM.  Severity of Illness and Comorbidity Scores as Predictors of Intensive Care Outcomes.  J Crit Care 2006; 21:142-150.
  • The Canadian Critical Care Trials Group.  A randomized trial of diagnostic techniques for ventilator-associated pneumonia.  N Engl J Med 2006;355:2619-2630.
  • Curtis JR, Cook DJ, Sinuff T, White DB, Hill N, Keenan S, Benditt JO, Kacmarek R, Kirchhoff KT, Levy MM. Noninvasive positive pressure ventilation in critical and palliative care settings: Understanding the goals of therapy.  Critical Care Medicine 2007; 35:932-939.
  • Keenan SP, Martin CM, Norena M, Wong H, Priestap F, Dodek PM.  Variation in length of ICU stay in patients admitted post-cardiac arrest.  Crit Care Med 2007; 35:836-841.
  • O’Donnell DE, Aaron S, Bourbeau J, Hernandez P, Marciniuk D, Balter M, Ford G, Gervais A, Goldstein R, Hodder R, Kaplan A, Keenan S, Lacasse Y, Maltais F, Road J, Rocker G, Sin D, Sinuff T, Voduc N.  Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease – 2007 update. Can Respir J 2007;14(Suppl):5B-32B.
  • Belway D, Dodek PM, Keenan SP, Norena M, Wong H.  The Role of Transport Intervals in Outcomes for Critically Ill Patients Who Are Transferred to Referral Centers. J Crit Care 2008; 23:287-294.
  • “Heyland DK, Dodek P, Muscedere J, Day A, Cook D; Canadian Critical Care Trials Group.  Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia.
  • Crit Care Med. 2008 Mar;36(3):737-44.”
  • “Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P, Lapinsky S, Baxter A, Russell J, Skrobik Y, Ronco JJ, Stewart TE; Lung Open Ventilation Study Investigators. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial.
  • JAMA. 2008 Feb 13;299(6):637-45.”
  • Muscedere J, Dodek PM, Keenan SP, Fowler R, Cook D, Heyland D for the VAP Guideline Committee and the Canadian Critical Care Trials Group.  Comprehensive Evidence-Based Clinical Practice Guidelines for Ventilator-Associated Pneumonia: Prevention  J Crit Care 2008, 23; 126-137.
  • Muscedere J, Dodek PM, Keenan SP, Fowler R, Cook DJ, Heyland DK for the VAP Guideline Committee and the Canadian Critical Care Trials Group.  Comprehensive Evidence-Based Clinical Practice Guidelines for Ventilator-Associated Pneumonia: Diagnosis and Treatment.  J Crit Care 2008, 23; 138-147.
  • Russell JA, Walley KR, Singer J, Gordon AC, Hébert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D; VASST Investigators.Vasopressin versus norepinephrine infusion in patients with septic shock.  N Engl J Med. 2008 Feb 28;358(9):877-87.
  • Sinuff T, Cook DJ, Keenan SP, Adhikari N, Eva K, Mehta S, Burns K, Rocker G, Hill NS. Noninvasive Ventilation for AcuteRespiratory Failure Near the End-of-Life. Crit Care Med 2008; 36:789-794.
  • Sweet DD, Naismith A, Keenan SP, Sinuff T, Dodek PM.  Missed opportunities for noninvasive positive pressure ventilation: a utilization review.  J Crit Care 2008; 23:111-117.
  • Azoulay E, Timsit JF, Sprung CL, et al. for the Conflicus Study Investigators.  Prevalence and factors of Intensive Care Unit conflicts: The Conflicus Study.  Am J Respir Crit Care Med 2009;180:853-860.
  • Burns KEA, Adhikari NKJ, Keenan SP, Meade M.  Noninvasive ventilation to wean critically ill adults from invasive mechanical ventilation:  a meta-analysis update.  BMJ 2009;338:b1574.
  • Keenan SP, Mehta S.  Noninvasive positive pressure ventilation for patients presenting with acute respiratory failure: the randomized controlled trials.  Resp Care 2009, Jan;54(1):116-26.
  • Kesecioglu J, Beale R, Stewart TE, et al. for the HL10 INT Study Group.  Exogenous natural surfactant for treatment of acute lung injury and the acute respiratory distress syndrome.  Am J Respir Crit Care Med 2009; 180:989-994.
  • Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. Critically ill patients with 2009 Influenza A (H1N1) infection in Canada.  JAMA. 2009 Nov 4;30
  • Martin CM, Priestap F, Fisher H, Fowler RA, Heyland DK, Keenan SP, Longo C, Morrison T, Bentley D, Antman N.  Outcomes, prevalence and incidence for patients with severe sepsis in a prospective, observational registry: The Canadian Sepsis Treatment and Response (STAR) Registry.  Crit Care Med 2009 Jan;37(1):81-8.
  • Mehta S, Al-Hashim AK, Keenan SP.  Noninvasive positive pressure ventilation in patients with acute cardiogenic pulmonary edema.  Resp Care 2009, Feb;54(2):186-97.
  • Burns KE, Meade MO, Lessard MR, Keenan SP, Lellouche F.  Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial. Trials. 2009 Sep 4;10:81.
  • Dodek PM, Keenan SP, Norena M, Martin C, Wong H.  Structure, process and outcome of all intensive care units within the province of British Columbia, Canada.  J Intensiv Care 2010, Jan 21, ahead of press, PMID: 20097666.
  • Dubord J, Dodek PM, Chan K, Keenan SP, Marion S, Wong H.  In-hospital death in critically ill patients who have congestive heart failure: does size of hospital matter?  Am J Med Qual 2010, Feb 9, ahead of press, PMID: 20145195.
  • Keenan SP. Systematic reviews: summarizing the existing literature.  Intensive Care Med 2010, in press.
  • Kumar A, Zarychanski R, Light B, Parrillo J, Maki D, Simon D, Laporta D, Lapinsky S, Ellis P, Mirzanejad Y, Martinka G, Keenan S, Wood G, Arabi Y, Feinstein D, Kumar A, Dodek P, Kravetsky L, Doucette S; Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Early combination antibiotic therapy yields improved survival compare to monotherapy in septic shock: a propensity anaylsis.  Crit Care Med. 2010 Sep;38(9):1773-85.
  • Burns KE, Adhikari NK, Keenan SP, Meade MO.  Noninvasive positive pressure ventilation as a weaning strategy for intubated adults with acute respiratory failure. Cochrane Database Syst Rev. 2010 Aug 4;(8):CD004127. Review.
  • Dodek PM, Norena M, Keenan SP, Teja A, Wong H. Intensive care unit admission for community-acquired pneumonia are seasonal but are not associated with weather or reports of influenza-like illness in the community. J Crit Care. 2010 Oct 29. [Epub ahead of print]PMID: 21036532.
  • Keenan SP. Noninvasive ventilation in acute lung injury: caution is good, more evidence is better.  Respir Care. 2010 Dec;55(12):1757-9.
  • Keenan SP, Sinuff T, Burns KE, Muscedere J, Kutsogiannis J, Mehta S, Cook DJ, Ayas N, Adhikari NK, Hand L, Scales DC, Pagnotta R, Lazosky L, Rocker G, Dial S, Laupland K, Sanders K, Dodek P; Canadian Critical Care Trials Group/Canadian Critical Care Society Noninvasive Ventilation Guidelines Group. Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting. CMAJ. 2011 Feb 22;183(3):E195-214. Epub 2011 Feb 14.
  • Dodek PM, Norena M, Keenan SP, Teja A, Wong H. Intensive care unit admissions for community-acquired pneumonia are seasonal but are not associated with weather or reports of influenza-like illness in the community. J Crit Care. 2011 Jun;26(3):228-33. Epub 2010 Oct 30.