Position:
Clinical Assistant Professor
Medical Oncologist, BC Cancer Agency – Vancouver Island Center
Division:
Medical Oncology
Research Interests:
  • Prognostic and predictive biomarkers in breast cancer/sarcoma/neuroendocrine tumor
  • Novel therapeutic intervention through genomic and transcriptome sequencing
  • Clinical and translational research in sarcoma
  • Phase 1/2/3 clinical trials in breast/sarcoma/neuroendocrine tumor
Education:
Medicine, Tongji Medical University, MD, MSc
Cancer Biology, University of Calgary, PhD
Cancer Biology, University of Calgary, Postdoctoral Fellowship
Recent Publications:

Refereed Publications

1. Xiaolan Feng, Erin Pleasance, Eric Y Zhao, Tony Ng, Jasleen K. Grewal, Nissreen Mohammad, Sara K. Taylor, Christine Simmons, Amirrtha Srikanthan, S. Rod Rassekh, Rebecca Deyell, Jennifer Rauw, Meg Knowling, Kong Khoo, Ursula Lee, Krista Noonan, Jason Hart, R Petter Tonseth,Yaoqing Shen, Emma Titmuss, Martin Jones, Melika Bonakdar, Caralyn Reisle, Greg A. Taylor, Simon Chan, Karen Mungall, Eric Chuah, Yongjun Zhao, Andrew Mungall, Richard Moore, Howard Lim, Daniel J. Renouf, Karen Gelmon, Stephen Yip, Steven J.M. Jones, Marco Marra and Janessa Laskin. Therapeutic implication of genomic landscape of adult metastatic sarcoma. Accepted March 2019 JCO Precision Oncology.

2. Angeline de Bruyns1, Haocheng Li2, Andrea MacNeil3, Christine Simmons4, Paul Clarkson3, Karen Goddard5, Peter Munk6, Jason Hart7, Caroline Holloway8, Pauline Truong8, Xiaolan Feng (corresponding author). Evolving practice patterns over two decades (1993-2013) in the management of desmoid-type fibromatosis (DF) in British Columbia. Submitted March 2019

3. Hui-li Wong, Kevin C. Yang, Yaoqing Shen, Eric Y. Zhao, Jonathan M. Loree, Hagen F. Kennecke, Steve E. Kalloger, Joanna M. Karasinska, Howard J. Lim, Andrew Mungall, Xiaolan Feng, Janine M. Davies, Kasmintan Schrader, Chen Zhou, Aly Karsan, Janessa Laskin, Marco A. Marra, David F. Schaeffer, Sharon M. Gorski, Daniel J. Renouf. Molecular characterisation of metastatic pancreatic neuroendocrine tumours (PNETs) using shole genome and transcriptome sequencing. Could Spring Harbor Molecular Case Studies 2017.

4. Xiaolan Feng (first and corresponding author), Tanya Berrang, John Paul McGhie, Peter Watson, R Petter Tonseth, Pauline T. Truong. Acute inflammatory response during neoadjuvant chemotherapy for locally advanced breast cancer. Cureus 2017

5. Xiaolan Feng (first and corresponding author), Haocheng Li, Elizabeth N Kornaga, Michelle Dean, Susan P Lees-Miller, Karl Riabowol, Anthony M Magliocco, Don Morris, Peter H Watson, Emeka K Enwere, Gwyn Bebb, and Alexander Paterson. Low Ki67/high ATM protein expression in malignant tumors predicts favorable prognosis in a retrospective study of early stage hormone receptor positive breast cancer. Oncotarget 2016 PMID: 27741524

6. Elizabeth N. Kornaga, John B. McIntyre, Alexander C. Klimowicz, Michelle L. Dean, Angela M.Y. Chan, Xiaolan Feng, Natalia Guggisberg, Don G. Morris and Anthony M. Magliocco. Evaluation of multiple methodologies for assessing HER2 in breast cancer specimens. Submitted 2016

7. Elizabeth N. Kornaga, Alexander Paterson, Xiaolan Feng, Don G. Morris, Anthony M. Magliocco and Alexander C. Klimowicz. Clinical utility of progesterone receptor: Revisiting and redefining an important breast cancer biomarker. Submitted 2016

8. Dong Hu, Wei Zhou, Fang Wang, Simin Shu, Jiaxi Duan, Lingling Fan, Jing He, Ping Wang, Yanli He, Wen Du, Li Sun, Xiaoqing Li, Huiyu Li, Xiaolan Feng (co-senior author), and Shiang Huang. Evaluation of NanoString nCounter technology as a novel diagnostic platform for profiling multiple mRNA and fusion transcripts in acute leukemia. International Journal of Laboratory Hematology 2016 Jul 27. PMID: 27460049

9. Xiaolan Feng (first and corresponding author), Haocheng Li, Michelle Dean, Holly E Willson, Alexander C. Klimowicz, Anthony M Magliocco, Patricia Tang and Gwyn Bebb. ATM protein loss is an independent prognostic factor in a retrospective study of early stage hormone negative breast cancer. Breast Cancer Res. 2015 May 3;17(1):65. PMID: 25935535

10. Xiaolan Feng (first and corresponding author), Don G Morris. Systemic treatments for gastrointestinal stromal tumor (GIST): A state of art. Oncology and Hematology Review,2014;10(2) 110-22. ww.touchoncology.com/articles/systemic-treatment-gastrointestinal-stromal-tumor-state-art

11. Bose P, Thakur S, Thalappilly S, Ahn BY, Satpathy S, Feng X, Suzuki K, Kim SW, Riabowol K. ING1 induces apoptosis through direct effects at the mitochondria. Cell Death Dis. 2013,4:e788 PMID:24008732

12. Don G Morris, Xiaolan Feng, Lisa M. DiFrancesco, Kevin Fonseca, Peter A Forsyth, Matt C. Coffey Brad Thompson and Alexander H. Paterson. REO-001. A phase I clinical trial of percutaneous intralesional administration of reovirus type 3 dearing (Reolysin®) in patients with advanced solid tumors. Investigational New Drugs 2013, 31(3):696-706. PMID: 22886613

13. Satber Thakur, Xiaolan Feng, Zong Q Shi, Amudha Ganapathy, Manoj K Mishra, Peter Atadja, Don Morris and Karl Riabowol. Targeting multiple epigenetic mechanisms effectively blocks breast cancer cell growth. PLoS One 2012, 7(8):e43671 PMID: 22916295

14. Xiaolan Feng, Liena Zhao, Guangming Han, Moosa Khalil, Francis Green, Travis Ogilvie, Vanessa Krause. A case report of an extremely rare and aggressive tumor: primary malignant pericardial mesothelioma. Rare tumors 2012, 4(2): 67-8. PMID: 22826778

15. Thalappilly S, Feng X (Co-first Author), Pastyryeva S, Suzuki K, Muruve D, Larocque D, Richard S, Truss M, von Deimling A, Riabowol K, Tallen G. The p53 Tumor Suppressor Is Stabilized by Inhibitor of Growth 1 (ING1) by Blocking polyubiquitination. PLoS One. 2011;6(6):e21065. PMID: 21731648

16. Heather Smith, Sitar Shah, Xiaolan Feng, Derrick E. Rancout and Karl Riabowol. ING function in apoptosis in diverse model systems. Biochem Cell Biol. 2009 Feb;87(1):117-25. PMID: 19234528

17. Xijing Han, Xiaolan Feng (Co-first Author), Jerome B. Rattners, Kyle J. Roux, Brain E. Burke and Karl T. Riabowol. Tethering of ING proteins to lamin A pontentiates ING protein function and is compromised in Hutchison-Gilford progeria cells. Nat Cell Biol. 2008 Nov;10(11):1333-40. PMID:18836436

18. Krishna P. Sarker, Hiromi Kataoka, Angela Chan, Stuart J. Netherton, Isabelle Pot, Xiaolan Feng, Karl Riabowol, and Shirin Bonni. ING2 as a Novel Mediator of TGF-b-Dependent Responses in Epithelial Cells. J Biol Chem. 2008 May 9;283(19):13269-79. PMID: 18334480

19. Walzak, Nik Veldhoen, Xiaolan Feng, Karl Riabowol, and Caren C. Helbing. Expression Profiles of mRNA Transcript Variants Encoding the Human Inhibitor of Growth Tumor Suppressor Gene Family in Normal and Neoplastic Tissues. Exp Cell Res. 2008 Jan 15;314(2):273-85. PMID: 17720155

20. Soliman, M., Berardi, P., Pastyryeva, S., Bonnefin, P., Suzuki, K., Feng, X.,Russell, M., Colina, A., Young, D. and Riabowol, K. Regulation of Chromatin Structure by Differential Expression of ING1 Splicing Isoforms during Cell Senescence. Aging cell 2008 Dec; 7(6):783-94. PMID:18691180

21. Feng Y, Wu J, Feng X, Tao D, Hu J, Qin J, Li X, Xiao W, Gardner K, Judge SI, Li QQ, Gong J. Timing of apoptosis onset depends on cell cycle progression in peripheral blood lymphocytes and lymphocytic leukemia cells. Oncol Rep. 2007 Jun;17(6):1437-44. PMID: 17487402

22. Xiaolan Feng, Shirin Bonni and Karl Riabowol. Induction of HSP70 by ING proteins sensitizes cells to TNF-a receptor mediated apoptosis. Mol Cell Biol. 2006 Dec;26(24):9244-55. PMID: 17030616

23. Kataoka, H., Bonnefin, P., Vieyra, D., Feng, X., Hara, Y., Miura, Y., Nakabayashi, H., Vaziri, H. and Riabowol, K. ING1 Represses transcription by direct DNA binding and through effects on p53. Cancer Res. 2003, 63:5785-92. PMID: 14522900

24. Feng, X., Hara, Y. and Riabowol, K. HATs of the ING proteins. Trends in Cell Biology 2002, 12: 532-538. PMID: 12446115

25. Deding Tao, Xiaolan Feng, Fanghe Li. The Application of CD71 and Hoechst33258 in Staining Method for Sorting Fetal Nucleated Red Blood Cells in the Peripheral Blood of Pregnant Women. Chinese Journal of Medical Genetics 2000, 17 (5) 352-354. PMI11024219

26. Xiaolan Feng, Iwona Auer-Grzesiak, Ian Scott. Atypical Presentation of Subcutaneous Panniculitis-Like T-Cell Lymphoma. Canadian Journal of General Internal Medicine March 2009, 4(1): 20-22

27. Xiaolan Feng, Siyuan Chen, Ning Dong. Study of Synergic Effect of Hybromic Acid BL Alkline on Oncomelania-killing Drugs. Marine Science of China 1998, 27: 23-28

28. Ph.D Thesis: Biochemical and Functional Characterization of the ING Tumor Suppressor Family. University of Calgary (2006)

Non-Refereed Publications

1. Xiaolan Feng, Michael Smylie, Jose Monzon, Tina Cheng, Richard Lee-Ying. The Impact of Clinical Response to First Induction of Anti-CTLA4 Treatment on Overall Survival (OS) in Metastatic Melanoma (MM). J Clin Oncol 32:5s, 2014 (suppl; abstr 9080)

2. Richard M. Lee-Ying, Xiaolan Feng, Michael Smylie, Jose Gerard Monzon, Tina Cheng; Efficacy of two ipilimumab (IPI) doses (10 vs. 3 mg/kg) in Alberta, Canada, tertiary cancer centers. J Clin Oncol 32:5s, 2014 (suppl; abstr 9090)

3. Xiaolan Feng, Elizabeth Freiheit, Donald Morisky, Karen Mulder, Quincy Chu, Vivien Bramwell, Don Morris. A Prospective Observational Cohort Study of Adherence to Oral Tyrosine Kinase Inhibitors (TKIs) in Gastrointestinal Stromal Tumor (GIST). Oncology Exchange Aug 2014 (abstract CAMO 2014)

29. M.Sc Thesis: Immunohistochemical Characteristics and Cytokine Gene Expression Patterns in Condyloma Acuminata. Tongji Medical University (2000)

Awards & Recognition:
  • Albert Heritage Foundation for Medical Research (AHFMR) Full-time Studentship 2004-2006
  • CIHR Strategic Training Program in Translational Cancer Research Grant Award 2004
  • Medical Science Graduate Research Scholarship, University of Calgary 2003
  • William H. Davies Medical Research Scholarship, University of Calgary 2002
  • Entrance Scholarship, University of Calgary 2001
  • Academic Excellence Scholarship, Tongji ,Medical University 1993-1997
  • 2017 Glenita Mungcal Research Award; Retrospective analysis of p16 expression in metastatic GIST
  • 2016-2018 Breast Cancer Society of Canada: New biostatistical methodologies for the analysis of breast cancer data with gene expression
  • 2015-2016 Breast Cancer Society of Canada: Determining prognostic value of ATM/Ki67 in early stage breast cancer
  • 2014-2015 Breast Cancer Society of Canada: Investigation of the role of ING2 in breast cancer
  • 2006-2008 Canadian Breast Cancer Foundation Prairies/NWT: Could ING Proteins be Novel Therapeutic Agents for Breast Cancer?
  • 2003-2004 NCIC/Canadian Prostate Cancer Research Initiative: Can ING Proteins selectively Induce Apoptosis in Prostate Cancer Cells?
  • 2002-2003 CIHR Aging Pilot Grant: Regulation of Gene Expression by the ING Proteins