Graydon S. Meneilly

Group Website


Vision Statement


Graydon S. Meneilly




Geriatric Medicine




Research Interests

Research Summary

My primary research interest for the last 30 years has been in the area of diabetes and carbohydrate metabolism in the elderly.  I have made a number of significant contributions to our understanding of the pathogenesis of glucose intolerance in the elderly as well as the pathogenesis and treatment of diabetes in older individuals.  I have established an international reputation in both these areas, particularly in the area of diabetes in the elderly.

Research Highlights


Education and Affiliations


MD University of Saskatchewan,


Publications and Awards

Recent Publications

  • Madden KM, Lockhart C, Cuff D, Potter TF, Meneilly GS. Aerobic training-induced improvements in arterial stiffness are not sustained in older adults with multiple cardiovascular risk factors. J Hum Hypertens. 2012 Sep 6.
  • Sinclair A, Morley JE, Rodriguez-Mañas L, Paolisso G, Bayer T, Zeyfang A, Bourdel-Marchasson I, Vischer U, Woo J, Chapman I, Dunning T, Meneilly G, Rodriguez-Saldana J, Gutierrez Robledo LM, Cukierman-Yaffe T, Gadsby R, Schernthaner G, Lorig K. Diabetes Mellitus in Older People: Position Statement on behalf of the International Association of Gerontology and Geriatrics (IAGG), the European Diabetes Working Party for Older People (EDWPOP), and the International Task Force of Experts in Diabetes. J Am Med Dir Assoc. 2012 Jul;13(6):497-502.
  • Stafford S, Elahi D, Meneilly GS. The effect of the dipeptidyl peptidase-4 inhibitor sitagliptin in elderly people with type 2 diabetes mellitus. J Am Geriatr Soc. 2011 Jun;59(6):1148-9.
  • Madden KM, Lockhart C, Potter TF, Cuff D, Meneilly GS. Short-term aerobic exercise reduces nitroglycerin-induced orthostatic intolerance in older adults with type 2 diabetes. J Cardiovasc Pharmacol 2011;57:666-671.
  • Meneilly GS et al. Effect of repaglinide vs glyburide on post-prandial glucose and insulin values in elderly patients with type 2 diabetes. Diabetes Technology and Therapeutics 2011;13:63-65.
  • Stafford S, Elahi D, Meneilly GS. The effect of the dipeptidyl peptidase-4 inhibitor sitagliptin in elderly people with type 2 diabetes mellitus. J Am Ger Soc. In press, 2011.
  • Thompson D, Meloche M, Ao Ziliang, Breay P, Keown P, Shapiro RJ, Ho S, Worsley D, Fung M, Meneilly GS et al. Reduced progression of diabetic microvascular complications with islet cell transplantation compared with intensive medical therapy. Transplantation 2011;91:373-378.
  • Gibson W, Liu J, Gaylinn B, Thorner MO, Meneilly GS, Babich SL, Thompson D, Chanoine J-P. Effects of glucose and insulin on acyl ghrelin and desacyl ghrelin, leptin, and adiponectin in pregnant women with diabetes. Metabolism Clinical and Experimental 2010 59: 841-847.
  • Guimaraes C, Marra CA, Gill S, Simpson S, Meneilly GS, Queiroz RHC, Lynd LD. A discrete choice experiment evaluation of patients’ preferences for different risk, benefit, and delivery attributes of insulin therapy for diabetes management. Patient Preference and Adherence 2010;4 433-440.
  • Guimaraes C, Marra CA, Gill S, Simpson SH, Meneilly GS, Queiroz RHC, Lynd LD. Exploring patients’ perceptions for insulin therapy in type 2 diabetes: a Brazilian and Canadian qualitative study. Patient Pref Adherence 2010:4 171-179.
  • Leung S, Mattman A, Snyder FF, Kassam R, Meneilly GS, Nexo E. Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients. Clinical Biochemistry 2010;43:759-760.
  • Abu-Hamdah R, Rabiee A, Meneilly GS, Shannon RP, Andersen DK, Elahi D. The Extra-Pancreatic Effects of GLP-1 and Related Peptides.  J Clin Endocrinol Metab. 2009 94: 1843-1852.
  • Guimarães C, Marra CA, Colley L, Gill S, Simpson SH, Meneilly GS, Queiroz RH, Lynd LD. A valuation of patients’ willingness-to-pay for insulin delivery in diabetes. Int J Assess Health Care. 2009 Jul;25(3):359-66.
  • Guimaraes C, Marra CA, Gill S, Simpson S, Meneilly G, Queiroz RHC, Lynd LD. Socio-economic Differences in Preferences and Willingness-To-Pay for Insulin Delivery Systems in Type 1 and Type 2 Diabetes. Diabetes Technology and Therapeutics, 11:567-73, 2009.
  • Halaschek-Wiener J, Amirabbasi-Beik M, Monfared N, Pieczyk M, Sailer C, Kollar A, Thomas R, Agalaridis G, Yamada S, Oliveira L, Collins JA, Meneilly G, Marra MA, Madden KM, Le ND, Connors JM, Brooks-Wilson AR. Genetic Variation in Healthy Oldest-Old. PLoS ONE 2009 4: e6641.
  • Klimek AM, Soukhatcheva G, Thompson DM, Warnock GL, Salehi M, Rilo H, D’Alessio D, Meneilly GS, Panagiotopoulos C, Verchere CB. Impaired Proinsulin Processing is a Characteristic of Transplanted Islets. Am J Transplant 2009 9: 2119-2125.
  • Madden KM, Lockhart C, Cuff D, Potter TF, Meneilly, GS. Short-term Aerobic Exercise Reduces Arterial Stiffness in Older Adults with Type 2 Diabetes, Hypertension and Hypercholesterolemia. Diabetes Care. 2009 32:1531-5.
  • Chanoine JP, Mackelvie KJ, Barr SI, Wong AC, Meneilly GS, Elahi DH. GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise. Obesity (Silver Spring) 2008 Jan;16(1):202-4.
  • Elahi D, Egan JM, Shannon RP, Meneilly GS, Khatri A, Habener JF, Andersen DK. GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity (Silver Spring) 2008 Jul;16(7):1501-9. Epub 2008 Apr 17.
  • Madden KM, Tedder G, Lockhart C, Meneilly GS. Euglycemic hyperinsulinemia alters the response to orthostatic stress in older adults with type 2 diabetes. Diabetes Care. 2008 31:2203-8.
  • Madden KM, Tedder G, Lockhart C, Meneilly GS. The Oral Glucose Tolerance Test Reduces Arterial Baroreflex Sensitivity in Older Adults. Can J Physio Pharm 2008 86(3):71-77.
  • Meneilly GS and multiple authors.  Canadian Diabetes Association 2008 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada.  Canadian Journal of Diabetes. 32 (Suppl 1) S181-186.  2008.
  • Thompson DM, Begg IS, Harris C, Ao Z, Fung MA, Meloche RM, Keown P, Meneilly GS, Shapiro RJ, Ho S, Dawson KG, Al Ghofaili K, Al Riyami L, Al Mehthel M, Kozak SE, Tong SO, Warnock GL. Reduced progression of diabetic retinopathy after islet cell transplantation compared with intensive medical therapy. Transplantation 2008 May 27;85(10):1400-5.
  • Fung MA, Warnock GL, Ao Z, Keown P, Meloch M, Shapiro RJ, Ho S, Worsley D. Meneilly GS, Al Ghofali K, Kozak SE, Tong SO, Trinh M, Blackburn L, Kozak RM, Fensom BA, Thompson DM.  The effect of medical therapy and islet cell transplantation on diabetic nephropathy: an interim report.  Transplantation 84(1): 17-22. 2007.
  • Kassam R, Meneilly GS.  Role of the pharmacist on a multi-disciplinary diabetes team.    Canadian Journal of Diabetes.  31(3): 215-222, 2007.
  • Khalil N, Fung M, Shapiro RJ, Warnock GL, Elahi D, Meneilly GS, Thompson D. Effect of Exenatide on Beta Cell Function After Islet Transplantation in Type 1 Diabetes.  Transplantation. 83: 24-38, 2007.
  • Mackelvie KJ, Meneilly GS, Elahi D, Wong ACK, Barr SI, Chanoine J-P. Regulation of Appetite in Lean and Obese Adolescents Following Exercise: Role of Acylated and Deacylated ghrelin.  J. Clin Endodrinol Metab. 92: 648-654, 2007.
  • Meneilly GS.  A comparison of Insulin aspart and regular insulin in elderly patients with type 2 diabetes. Diabetes, Obesity and Metabolism.  9: 754-755, 2007.
  • Fung M, Thompson D, Shapiro RJ, Warnock GL, Andersen DK, Elahi D, Meneilly GS.  Effect of glucagon-like peptide-1 on beta cell function after islet transplantation in type I diabetes.  Diabetes Res Clin Pract 74: 189-193 (2006).
  • Meneilly GS, Elahi D.  Effect of GLP-1 on the ß cell response to GIP in elderly patients with diabetes.   J Am Geriatric Soc, 54:554-555 (2006).
  • Meneilly GS, Veldhuis JD, Elahi D.  Pulsatile insulin secretion in elderly patients with diabetes. Diabetes Res Clin Pract 73: 218-220 (2006).

Awards & Recognition