James C. Johnston

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Vision Statement

Dr.

James C. Johnston

Position

Clinical Associate Professor, Head of Respiratory Medicine Division at Vancouver General Hospital, Evaluation Lead at Provincial TB Services at BCCDC, Associate Member of the UBC School of Population & Public Health

Division

Respiratory

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Overview
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Research Interests

Dr. Johnston’s research interests include TB epidemiology, treatment outcomes, drug resistance and genomics.

Research Summary

Research Highlights

Personal

Education and Affiliations
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Education

Master of Public Health (MPH), Harvard School of Public Health,

Affiliations

Publications and Awards
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Recent Publications

1: Ronald LA, Campbell JR, Rose C, Balshaw R, Romanowski K, Roth D, Marra F,
Schwartzman K, Cook VJ, Johnston JC. Estimated impact of World Health
Organization latent tuberculosis screening guidelines in a low TB incidence
region: retrospective cohort study. Clin Infect Dis. 2019 Mar 11. pii: ciz188.
doi: 10.1093/cid/ciz188. [Epub ahead of print] PubMed PMID: 30856258.

2: Romanowski K, Campbell JR, Oxlade O, Fregonese F, Menzies D, Johnston JC. The
impact of improved detection and treatment of isoniazid resistant tuberculosis on
prevalence of multi-drug resistant tuberculosis: A modelling study. PLoS One.
2019 Jan 24;14(1):e0211355. doi: 10.1371/journal.pone.0211355. eCollection 2019.
PubMed PMID: 30677101; PubMed Central PMCID: PMC6345486.

3: Romanowski K, Balshaw RF, Benedetti A, Campbell JR, Menzies D, Ahmad Khan F,
Johnston JC. Predicting tuberculosis relapse in patients treated with the
standard 6-month regimen: an individual patient data meta-analysis. Thorax. 2019
Mar;74(3):291-297. doi: 10.1136/thoraxjnl-2017-211120. Epub 2018 Nov 12. PubMed
PMID: 30420407.

4: Campbell JR, Johnston JC, Ronald LA, Sadatsafavi M, Balshaw RF, Cook VJ, Levin
A, Marra F. Screening for Latent Tuberculosis Infection in Migrants With CKD: A
Cost-effectiveness Analysis. Am J Kidney Dis. 2019 Jan;73(1):39-50. doi:
10.1053/j.ajkd.2018.07.014. Epub 2018 Sep 28. PubMed PMID: 30269868.

5: Kapur VK, Johnston JC, Rueschman M, Bakker JP, Donovan LM, Hanson M,
Harrington Z, Weng J, Redline S. Patient satisfaction with sleep study
experience: findings from the Sleep Apnea Patient-Centered Outcomes Network.
Sleep. 2018 Aug 1;41(8). doi: 10.1093/sleep/zsy093. PubMed PMID: 29741736.

6: Fregonese F, Ahuja SD, Akkerman OW, Arakaki-Sanchez D, Ayakaka I, Baghaei P,
Bang D, Bastos M, Benedetti A, Bonnet M, Cattamanchi A, Cegielski P, Chien JY,
Cox H, Dedicoat M, Erkens C, Escalante P, Falzon D, Garcia-Prats AJ, Gegia M,
Gillespie SH, Glynn JR, Goldberg S, Griffith D, Jacobson KR, Johnston JC,
Jones-López EC, Khan A, Koh WJ, Kritski A, Lan ZY, Lee JH, Li PZ, Maciel EL,
Galliez RM, Merle CSC, Munang M, Narendran G, Nguyen VN, Nunn A, Ohkado A, Park
JS, Phillips PPJ, Ponnuraja C, Reves R, Romanowski K, Seung K, Schaaf HS,
Skrahina A, Soolingen DV, Tabarsi P, Trajman A, Trieu L, Banurekha VV, Viiklepp
P, Wang JY, Yoshiyama T, Menzies D. Comparison of different treatments for
isoniazid-resistant tuberculosis: an individual patient data meta-analysis.
Lancet Respir Med. 2018 Apr;6(4):265-275. doi: 10.1016/S2213-2600(18)30078-X.
Erratum in: Lancet Respir Med. 2018 Apr 18;:. PubMed PMID: 29595509.

7: Sartwelle TP, Johnston JC. Continuous Electronic Fetal Monitoring during
Labor: A Critique and a Reply to Contemporary Proponents. Surg J (N Y). 2018 Mar
7;4(1):e23-e28. doi: 10.1055/s-0038-1632404. eCollection 2018 Jan. Review. PubMed
PMID: 29527573; PubMed Central PMCID: PMC5842073.

8: Ronald LA, Campbell JR, Balshaw RF, Romanowski K, Roth DZ, Marra F, Cook VJ,
Johnston JC. Demographic predictors of active tuberculosis in people migrating to
British Columbia, Canada: a retrospective cohort study. CMAJ. 2018 Feb
26;190(8):E209-E216. doi: 10.1503/cmaj.170817. PubMed PMID: 29483329; PubMed
Central PMCID: PMC5826706.

9: Johnston JC, van der Kop ML, Smillie K, Ogilvie G, Marra F, Sadatsafavi M,
Romanowski K, Budd MA, Hajek J, Cook V, Lester RT. The effect of text messaging
on latent tuberculosis treatment adherence: a randomised controlled trial. Eur
Respir J. 2018 Feb 7;51(2). pii: 1701488. doi: 10.1183/13993003.01488-2017. Print
2018 Feb. PubMed PMID: 29437940.

10: Sartwelle TP, Johnston JC, Arda B. A half century of electronic fetal
monitoring and bioethics: silence speaks louder than words. Matern Health
Neonatol Perinatol. 2017 Nov 21;3:21. doi: 10.1186/s40748-017-0060-2. eCollection
2017. Review. PubMed PMID: 29201387; PubMed Central PMCID: PMC5697350.

11: Campbell JR, Johnston JC, Sadatsafavi M, Cook VJ, Elwood RK, Marra F.
Cost-effectiveness of post-landing latent tuberculosis infection control
strategies in new migrants to Canada. PLoS One. 2017 Oct 30;12(10):e0186778. doi:
10.1371/journal.pone.0186778. eCollection 2017. PubMed PMID: 29084227; PubMed
Central PMCID: PMC5662173.

12: Patel AR, Campbell JR, Sadatsafavi M, Marra F, Johnston JC, Smillie K, Lester
RT. Burden of non-adherence to latent tuberculosis infection drug therapy and the
potential cost-effectiveness of adherence interventions in Canada: a simulation
study. BMJ Open. 2017 Sep 15;7(9):e015108. doi: 10.1136/bmjopen-2016-015108.
PubMed PMID: 28918407; PubMed Central PMCID: PMC5640098.

13: Romanowski K, Chiang LY, Roth DZ, Krajden M, Tang P, Cook VJ, Johnston JC.
Treatment outcomes for isoniazid-resistant tuberculosis under program conditions
in British Columbia, Canada. BMC Infect Dis. 2017 Sep 4;17(1):604. doi:
10.1186/s12879-017-2706-0. PubMed PMID: 28870175; PubMed Central PMCID:
PMC5583994.

14: Butt ZA, Shrestha N, Wong S, Kuo M, Gesink D, Gilbert M, Wong J, Yu A,
Alvarez M, Samji H, Buxton JA, Johnston JC, Cook VJ, Roth D, Consolacion T, Murti
M, Hottes TS, Ogilvie G, Balshaw R, Tyndall MW, Krajden M, Janjua NZ; BC
Hepatitis Testers Cohort. A syndemic approach to assess the effect of substance
use and social disparities on the evolution of HIV/HCV infections in British
Columbia. PLoS One. 2017 Aug 22;12(8):e0183609. doi:
10.1371/journal.pone.0183609. eCollection 2017. PubMed PMID: 28829824; PubMed
Central PMCID: PMC5568727.

15: Sartwelle TP, Johnston JC, Arda B. The Ethics of Teaching Physicians
Electronic Fetal Monitoring: And Now for the Rest of the Story. Surg J (N Y).
2017 Mar 20;3(1):e42-e47. doi: 10.1055/s-0037-1599229. eCollection 2017 Jan.
PubMed PMID: 28825019; PubMed Central PMCID: PMC5553489.

16: Hatherell HA, Didelot X, Pollock SL, Tang P, Crisan A, Johnston JC, Colijn C,
Gardy JL. Declaring a tuberculosis outbreak over with genomic epidemiology.
Microb Genom. 2016 May 31;2(5):e000060. doi: 10.1099/mgen.0.000060. eCollection
2016 May. PubMed PMID: 28348853; PubMed Central PMCID: PMC5320671.

17: Roth DZ, Ronald LA, Ling D, Chiang LY, Cook VJ, Morshed MG, Johnston JC.
Impact of interferon-γ release assay on the latent tuberculosis cascade of care:
a population-based study. Eur Respir J. 2017 Mar 22;49(3). pii: 1601546. doi:
10.1183/13993003.01546-2016. Print 2017 Mar. PubMed PMID: 28331032.

18: Johnston JC, Campbell JR, Menzies D. Effect of Intermittency on Treatment
Outcomes in Pulmonary Tuberculosis: An Updated Systematic Review and
Metaanalysis. Clin Infect Dis. 2017 May 1;64(9):1211-1220. doi:
10.1093/cid/cix121. Review. PubMed PMID: 28203783.

19: Johnston JC, Chiang L, Elwood K. Mycobacterium kansasii. Microbiol Spectr.
2017 Jan;5(1). doi: 10.1128/microbiolspec.TNMI7-0011-2016. Review. PubMed PMID:
28185617.

20: Johnston JC, Sartwelle TP. Letter re: Neuroimaging overuse is more common in
Medicare compared with the VA. Neurology. 2017 Feb 7;88(6):608. doi:
10.1212/WNL.0000000000003593. PubMed PMID: 28167624.

21: Johnston JC, Sartwelle TP. Letter re: Neuroimaging overuse is more common in
Medicare compared with the VA. Neurology. 2017 Feb 7;88(6):607. doi:
10.1212/WNL.0000000000003580. PubMed PMID: 28167622.

22: Ronald LA, Campbell JR, Balshaw RF, Roth DZ, Romanowski K, Marra F, Cook VJ,
Johnston JC. Predicting tuberculosis risk in the foreign-born population of
British Columbia, Canada: study protocol for a retrospective population-based
cohort study. BMJ Open. 2016 Nov 25;6(11):e013488. doi:
10.1136/bmjopen-2016-013488. PubMed PMID: 27888179; PubMed Central PMCID:
PMC5168543.

23: Johnston JC, Wester K, Sartwelle TP. Neurological Fallacies Leading to
Malpractice: A Case Studies Approach. Neurol Clin. 2016 Aug;34(3):747-73. doi:
10.1016/j.ncl.2016.04.011. Review. PubMed PMID: 27445252.

24: Romanowski K, Clark EG, Levin A, Cook VJ, Johnston JC. Tuberculosis and
chronic kidney disease: an emerging global syndemic. Kidney Int. 2016
Jul;90(1):34-40. doi: 10.1016/j.kint.2016.01.034. Epub 2016 May 10. Review.
PubMed PMID: 27178832.

25: Redline S, Baker-Goodwin S, Bakker JP, Epstein M, Hanes S, Hanson M,
Harrington Z, Johnston JC 2nd, Kapur VK, Keepnews D, Kontos E, Lowe A, Owens J,
Page K, Rothstein N; Sleep Apnea Patient-Centered Outcomes Network. Patient
Partnerships Transforming Sleep Medicine Research and Clinical Care: Perspectives
from the Sleep Apnea Patient-Centered Outcomes Network. J Clin Sleep Med. 2016
Jul 15;12(7):1053-8. doi: 10.5664/jcsm.5948. Review. PubMed PMID: 27166300;
PubMed Central PMCID: PMC4918988.

26: Sartwelle TP, Johnston JC, Arda B. Perpetuating Myths, Fables, and Fairy
Tales: A Half Century of Electronic Fetal Monitoring. Surg J (N Y). 2015 Nov
20;1(1):e28-e34. doi: 10.1055/s-0035-1567880. eCollection 2015 Dec. PubMed PMID:
28824967; PubMed Central PMCID: PMC5530627.

27: Johnston JC, Khan FA, Dowdy DW. In reply. Int J Tuberc Lung Dis. 2015
Oct;19(10):1264. doi: 10.5588/ijtld.15.0518-2. PubMed PMID: 26459551.

28: Johnston JC. Imaging the Patient With Migraine: A Question Answered.
Headache. 2015 Nov-Dec;55(10):1442-3. doi: 10.1111/head.12653. Epub 2015 Aug 28.
PubMed PMID: 26314249.

29: Sartwelle TP, Johnston JC. Neonatal encephalopathy 2015: opportunity lost and
words unspoken. J Matern Fetal Neonatal Med. 2016;29(9):1372-5. doi:
10.3109/14767058.2015.1051526. Epub 2015 Jun 11. Review. PubMed PMID: 26067269.

30: Johnston JC, Khan FA, Dowdy DW. Reducing relapse in tuberculosis treatment:
is it time to reassess WHO treatment guidelines? Int J Tuberc Lung Dis. 2015
Jun;19(6):624. doi: 10.5588/ijtld.15.0224. PubMed PMID: 25946348.

31: Johnston JC, Ruthruff E, Lien MC. Visual information processing from multiple
displays. Hum Factors. 2015 Mar;57(2):276-97. doi: 10.1177/0018720814545974. Epub
2014 Aug 4. PubMed PMID: 25850158.

32: Wlodarska M, Johnston JC, Gardy JL, Tang P. A microbiological revolution
meets an ancient disease: improving the management of tuberculosis with genomics.
Clin Microbiol Rev. 2015 Apr;28(2):523-39. doi: 10.1128/CMR.00124-14. Review.
PubMed PMID: 25810419; PubMed Central PMCID: PMC4402953.

33: Mengistu G, Ewunetu BD, Johnston JC, Metaferia GZ. Neuroimaging of Ethiopian
patients with epilepsy: a retrospective review. Ethiop Med J. 2014
Apr;52(2):57-66. PubMed PMID: 25588286.

34: Sartwelle TP, Johnston JC. Cerebral palsy litigation: change course or
abandon ship. J Child Neurol. 2015 Jun;30(7):828-41. doi:
10.1177/0883073814543306. Epub 2014 Sep 2. Review. PubMed PMID: 25183322; PubMed
Central PMCID: PMC4431995.

35: Cheng MP, Hirji A, Roth DZ, Cook VJ, Lima VD, Montaner JS, Johnston JC.
Tuberculosis in HIV-infected persons in British Columbia during the HAART era.
Can J Public Health. 2014 May 30;105(4):e258-62. PubMed PMID: 25166127.

36: Johnston JC, Haile A, Wang D, Ronnett G, Jones LC. Dexamethasone treatment
alters function of adipocytes from a mesenchymal stromal cell line. Biochem
Biophys Res Commun. 2014 Sep 5;451(4):473-9. doi: 10.1016/j.bbrc.2014.07.063.
Epub 2014 Jul 29. PubMed PMID: 25078627.

37: Weiss P, Chen W, Cook VJ, Johnston JC. Treatment outcomes from
community-based drug resistant tuberculosis treatment programs: a systematic
review and meta-analysis. BMC Infect Dis. 2014 Jun 17;14:333. doi:
10.1186/1471-2334-14-333. Review. PubMed PMID: 24938738; PubMed Central PMCID:
PMC4071022.

More Publications are available on Google Scholar.

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