Katherine Plewes

Portrait photo of Katherine Plewes

Group Website

Address

Heather Pavilion East 452D
2733 Heather Street
Vancouver, BC V5Z 3J5
Canada

Vision Statement

Dr.

Katherine Plewes

MSc, MD, DTMH, FRCPC, DPhil

Position

Clinical Assistant Professor

Division

Infectious Diseases

Phone

Email

Katherine.plewes@vch.ca

Overview
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Research Interests

Global Health, Infectious Diseases, Tropical medicine, Parasitology, Malaria, Travel and Migration medicine

Research Summary

Dr. Plewes is an Adult Infectious Diseases specialist and Honorary Visiting Research Fellow in Tropical Medicine, University of Oxford, with research interests in malaria and tropical diseases. She works with an international and multidisciplinary team focused on the pathophysiology and treatment of severe malaria, and the causes of fever and antimicrobial susceptibility of bacterial pathogens causing fever in low-, middle-, and high-income settings. She has extensive field experience, currently working on active projects in Bangladesh and the Democratic Republic of the Congo. She is also Vancouver Site Lead for the GeoSentinel Surveillance Network, a global network of 70 sites in 31 countries that conducts surveillance of emerging infectious diseases using returning travelers, immigrants, and refugees as sentinels of infection.

Research Highlights

Personal

Education and Affiliations
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Education

University of Oxford, DPhil,

University of British Columbia, , Infectious Diseases, FRCPC,

University of Liverpool, Diploma in Tropical Medicine and Hygiene,

University of British Columbia, Internal Medicine , FRCPC,

University of Calgary, MD,

University of Calgary, MSc,

University of Calgary, BSc,

Affiliations

Nuffield Department of Medicine, University of Oxford, Honorary Visiting Research Fellow

Public Health Agency of Canada, Committee to Advise on Tropical Medicine and Travel (CATMAT), Committee Member

Public Health Agency of Canada, Canadian Malaria Network, British Columbia Designate Physician

GeoSentinel Surveillance Network, Vancouver Site Director

Publications and Awards
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Recent Publications

  1. Ishioka H, Plewes K, Pattnaik R, Kingston HWF, Leopold SJ, Herdman MT, Mahanta K, Mohanty A, Dey C, Alam S, Srinamon K, Mohanty A, Maude RJ, White NJ, Day NPJ, Hossain MA, Faiz, MA, Charunwatthana P, Mohanty S, Ghose A, Dondorp AM. Associations between restrictive fluid management and renal function and tissue perfusion in adults with severe falciparum malaria- a prospective observational study. Journal of Infectious Diseases 2019. [epub ahead of print]. PMID: 31504666.
  2. Leopold SJ, Apinan S, Ghose A, Kingston HW, Plewes K, Hossain A, Dutta AK, Paul S, Barua A, Sattar A, Day NPJ, Tarning J, Winterberg M, White NJ, Dondorp AM. Amino acid derangements in adults with severe falciparum malaria. Scientific Reports 2019. 9(1): 6602. PMID: 31036854.
  3. Kingston HW, Ghose A, Rungpradubvong V, Herdman MT, Plewes K, Ishioka H, Leopold SJ, Maude RJ, Intharabut B, Mohanty S, Day NPJ, White NJ, Hossain MA, Anstey NM, Dondorp AM. Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study. Malaria Journal 2019. 18(1):97. PMID: 30909915.
  4. Plewes K, Leopold SJ, Kingston HWF, Dondorp AM. Malaria: What’s new in the management of malaria? Infectious Diseases Clinics of North America. 2019 Mar; 33(1):33-60. PMID: 30712767.
  5. Leopold SJ, Ghose A, Allman EL, Kingston HWF, Hossain A, Butta AK, Plewes K, Chotivanich, K, Day NPJ, Tarning J, Winterberg M, White NJ, Llinas M, Dondorp AM. Identifying the components of acidosis in patients with severe P. falciparum malaria using metabolomics. Journal of Infectious Diseases. 2018 Dec. [Epub ahead of print]. PMID: 30566600.
  6. Leopold SJ, Ghose A, Plewes K, Mazumder S, Pisani L, Kingston HWF, Paul S, Barua A, Sattar MA, Huson MAM, Walden AP, Henwood PC, Riviello ED, Schultz MJ, Day NPJ, Kumar Dutta A, White NJ, Dondorp AM. Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study. PLoS One. 2018 Dec 12;13(12):e0204832. PMID: 30540757.
  7. Kam RKT, Chan MHM, Wong HT, Ghose A, Dondorp AM, Plewes K, Tarning J. Quantitation of paracetamol by liquid chromatography-mass spectrometry in human plasma in support of clinical trial. Future Science OA 2018; 4(8): FS0331. PMID: 30271617.
  8. Cooper DJ, Plewes K, Grigg MJ, Rajahram G, Piera KA, Williams T, Chatfield MD, Yeo TW, Dondorp AM, Anstey NM, Barber BE. The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW): a study protocol for a randomised controlled trial. Trials 2018; 19(1):250. PMID: 29690924.
  9. Barber BE, Grigg MJ, Piera KA, William T, Cooper DJ, Plewes K, Dondorp AM, Yeo TW, Anstey NM. Intravascular hemolysis in severe Plasmodium knowlesi malaria: association with endothelial activation, microvascular dysfunction, and acute kidney injury. Emerging Microbes and Infections 2018; 7:106. PMID: 29872039.
  10. Plewes K, Kingston HW, Ghose A, Hassan MMU, Haider MS, Alam S, Islam MA, Faiz MA, Herdman MT, Leopold SJ, Ishioka H, Wattanakul T, Piera KA, Charunwatthana P, Silamut K, Yeo TW Lee SJ, Mukaka M, Maude RJ, Tarning J, Turner GDH, Oates JA, Anstey NM, White NJ, Day NPJ, Hossain MA, Roberts LJ, Dondorp AM. Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe falciparum malaria: A randomized, controlled, open-label trial. Clinical Infectious Diseases 2018; 67(7):991-999. PMID: 29538635.
  11. Sriboonvorakul N, Ghose A, Hassan MMU, Hossain MA, Faiz MA, Mishra S, Pukrittayakamee S, Chotivanich K, Sukthana Y, Leopold SJ, Plewes K, Tarning J, Day NPJ, White NJ, Tarning J, Dondorp AM. Acidosis and acute kidney injury in severe malaria. Malaria Journal 2018; 17(1):128. PMID: 29566677.
  12. Kingston HW, Hossain M, Leopold SJ, Anantatat T, Tanganuchitcharnchai A, Sinha I, Plewes K, Maude RJ, Chowdhury MAH, Paul S, Alam R, Uddin ME, Siddiqui MAN, Shahed A, Zahed M, Abu Sayeed A, Rahman MH, Barua A, Uddin MJ, Sattar MA, Dondorp AMD, Blacksell SD, Day NPJ, Ghose A, Hossain MA, Paris DH. Rickettsial illnesses as important causes of febrile illness in Chittagong, Bangladesh. Emerging Infectious Disease 2018; 24(4). PMID: 29553921.
  13. Plewes K, Turner GDH, Dondorp AM. Pathophysiology, clinical presentation and treatment of coma and acute kidney injury complicating falciparum malaria. Current Opinion in Infectious Diseases 2018; 31(1):69-77. PMID: 29206655.
  14. Kingston HW, Ghose A, Plewes K, Ishioka H, Leopold SJ, Maude RJ, Paul S, Intharabut B, Silamut K, Woodrow C, Day NPJ, Chotivanich K, Anstey NM, Hossain A, White NJ, Dondorp AM. Disease severity and effective parasite multiplication rate in falciparum malaria. Open Forum Infectious Diseases 2017; 4(4). PMID: 29302604.
  15. Ndour PA, Larréché S, Mouri O, Argy N, Gay F, Roussel C, Jauréguiberry S, Perillaud C, Langui D, Biligui S, Chartrel N, Mérens A, Kendjo E, Ghose A, Hassan MMU, Hossain MA, Kingston HWF, Plewes K, Dondorp AM, Danis M, Houzé S, Bonnefoy S, Thellier M, Woodrow CJ, Buffet PA; French Artesunate Working Group. Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis. Science Translational Medicine 2017; 5;9(397). PMID: 28679662.
  16. Plewes K, Soontarawirat I, Ghose A, Bancone G, Kingston HWF, Herdman MT, Leopold SJ, Ishioka H, Faiz MA, Anstey NM, Day NPJ, Hossain MA, Imwong M, Dondorp AM, Woodrow CJ. Genotypic and phenotypic characterization of G6PD deficiency in Bengali adults with severe and uncomplicated malaria. Malaria Journal 2017;16(1):134. PMID: 28356147.
  17. Plewes K, Kingston HW, Ghose A, Maude RJ, Herdman MT, Hasan, MU, Haider MS, Alam S, Piera K, Charunwatthana P, Yeo TW, Lee SJ, Turner GDH, Faiz MA, Anstey NM, Roberts LJ, White NJ, Day NPJ, Hossain A, Dondorp AM. Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study. BMC Infectious Diseases 2017; 17(1):313. PMID: 28449641.
  18. Jeeyapant A, Kingston HW, Plewes K, Maude RJ, Hanson J, Herdman MT, Leopold SJ, Ngernseng T, Charunwatthana P, Phu NH, Ghose A, Hasan MM, Fanello CI, Faiz MA, Hien TT, Day NP, White NJ, Dondorp AM. Defining Surrogate endpoints for clinical trials in severe falciparum malaria. PLoS One 2017; 12(1):e0169307. doi: 10.1371/journal.pone.0169307. PMID: 28052109.
  19. Wattanakul T, Teerapong P, Plewes K, Newton P, Chierakul W, Ruangveerayuth R, Silamut K, Chotivanich K, White NJ, Dondorp AM, Tarning J. Pharmacokinetic properties of intramuscular versus oral paracetamol in falciparum malaria. Malaria Journal 2016; 15:244-255. PMID: 27118212.
  20. Ishioka H, Ghose A, Charunwatthana P, Maude R, Plewes K, Kingston H, Intharabut B, Woodrow C, Chotivanich K, Sayeed AA, Hasan MU, Day NP, Faiz MA, White NJ, Hossain A, Dondorp AM. Sequestration and red cell deformability as determinants of hyperlactataemia in falciparum malaria. Journal of Infectious Diseases 2016; 19(1):382. PMID: 26494775.
  21. Plewes K, Maude RJ, Ghose A, Dondorp AM. Severe falciparum malaria complicated by prolonged haemolysis and rhinomaxillary mucormycosis after parasite clearance: a case report. BMC Infectious Diseases 2015; 15(1):555. PMID: 26634340.
  22. Herdman MT, Sriboonvorakul N, Leopold SJ, Douthwaite S, Mohanty S, Hassan MU, Maude RJ, Kingston HWF, Plewes K, Charunwatthana P, Silamut K, Woodrow CJ, Chotinavich K, Hossain MA, Faiz MA, Mishra S, Leepipatpiboon, N, White NJ, Day NPJ, Tarning J, Dondorp AM. The role of previously unmeasured organic acids in the pathogenesis of severe malaria. Critical Care 2015; 19:317. PMID: 26343146.
  23. Plewes K, Haider MS, Kingston HW, Yeo TW, Ghose A, Hossain MA, Dondorp AM, Turner GDH, Anstey NM. Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury. Malaria Journal 2015; 14:246. PMID: 26081927.
  24. Hanson J, Lee SJ, Hossain MA, Charunwatthana P, Maude RJ, Kingston HWF, Mishra SK, Mohanty S, Plewes K, Piera K, Hassan MU, Ghose A, Faiz MA, White NJ, Day NPJ, Dondorp AM. Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults. BMC Medicine 2015; 13(1):122. PMID: 26018532.
  25. Hanson J, Phu NH, Hasan MU, Charunwatthana P, Plewes K, Maude RJ, Prapansilp P, Kingston HW, Mishra SK, Mohanty S, Price RN, Faiz MA, Dondorp AM, White NJ, Hien TT, Day NPJ. The clinical implications of thrombocytopenia in adults with severe falciparum malaria: a retrospective analysis. BMC Medicine 2015;13(1): 97. PMID: 25907925.
  26. Tun KM, Imwong M, Lwin KM, Win AA, Hlaing, TM, Hlaing T, Lin K, Kyaw MP, Plewes K, Faiz MA, Dhorda M, Cheah PY, Pukrittayakamee S, Ashley EA, Anderson TJ, Nair S, McDew-White M, Flegg JA, Grist EP, Guerin P, Maude RJ, Smithius F, Dondorp AM, Day NP, Nosten F, White NJ, Woodrow CJ. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: as cross-sectional survey of the K13 molecular marker. Lancet Infectious Diseases 2015; 15(4):415-421. PMID: 25704894.
  27. Plewes K, Royakkers AA, Hanson J, Hasan MMU, Alam S, Ghose A, Maude RJ, Stassen PM, Prakaykaew C, Lee SJ, Turner GDH, Dondorp AM, Schultz, MJ. Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria. Malaria Journal 2014;13:91. PMID: 24618154.
  28. Maude RJ, Barkhof F, Hassan MU, Ghose A, Hossain A, Faiz MA, Choudury E, Rashid R, Abu Sayeed A, Charunwatthana P, Plewes K, Kingston H, Maude RR, Silamut K, Day NPJ, White NJ, Dondorp AM. MRI of the brain in adults with severe falciparum malaria. Malaria Journal 2014; 13:177. PMID: 24884982.
  29. Maude RJ, Silamut K, Plewes K, Charunwatthana P, Ho M, Faiz MA, Rahman R, Hossain MA, Hassan MU, Bin   Yunus E, Hoque G, Islam F, Ghose A, Hanson J, Schlatter J, Lacey R, Eastaugh A, Tarning J, Lee SJ, White NJ, Chotivanich K, Day NP, Dondorp AM. Randomised controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitaemia. Journal of Infectious Diseases 2014; 209:120-129. PMID: 23943850.
  30. Maude RJ, Plewes K, Charunwatthana P, Faiz MA, Yunus EB, Gofranul Hoque M, Hasan MU, Hossain A, Day NPJ, White NJ, Dondorp AM. Does artesunate prolong the QT interval in patients with severe malaria? American Journal of Tropical Medicine and Hygiene 2009; 80(1):126–132. PMID: 19141850.
    More Publications can be found on PubMed

Awards & Recognition

  • Michael Smith Foundation for Health Research Health Professional-Investigator Award (2019 –2024)
  • IDSA ERF/NFID Merle A. Sande/Pfizer Fellowship in International Infectious Diseases (2011-2012)
Grants
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Grants

  • Canadian Institutes of Health Research Project Grant recipient; Primary Investigator (2019-2022)
  • Li Ka Shing Foundation – Asia Research Network Seed Award- University of Oxford; Co-Primary investigator (2012-2013)
Teaching/Students
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  • UBC Tropical and Geographic Medicine Intensive Short Course – Annual; Co-director and lecturer
  • UBC Tropical Medicine Rounds- Weekly; Coordinator and lecturer
  • UBC Post-graduate Clinical Research Program, Department of Pediatrics; Mentor
  • UBC Pathology 722: Medical Microbiology; Malaria and babesiosis; Lecturer