Critical Care Medicine
Vision Statement:

Advancing knowledge to improve outcomes of critically ill patients.

Research Interests:

Sepsis, ventricular dysfunction, genetic determinants of critical illness

Research Summary:

The focus of Dr. Walley’s research is to investigate 1) the mechanism of decreased left ventricular contractility and other organ failure during sepsis and 2) the impact of genotype on patient outcomes in sepsis and systemic inflammatory states. Clinical research and development of local biotech are used to translate bench discoveries to clinical application.

BSc (Hons Physics), MD, University of Manitoba
Internal Medicine Residency, McGill University
Pulmonary Critical Care Fellowship, University of Chicago
Recent Publications:
  • Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA. Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med 38(2):259-265, 2011
  • von Dadelszen P, Payne B, Li J, Ansermino JM, Broughton-Pipkin F, Cote AM, Douglas JM, Gruslin A, Hutcheon JA, Joseph KS, Kyle PM, Lee T, Loughna P, Menzies JM, Merialdi M, Millman AL, Moore MP, Moutquin JM, Ouellet AB, Smith GN, Walker JJ, Walley KR, Walters BN, Widmer M, Lee SK, Russell JA, Magee LA for the PIERS Study Group. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet, 377(9761):219-227, 2011.
  • Walley KR. Use of central venous oxygen saturation to guide therapy. Am J Respir Crit Care Med, 184: 514-520, 2011.
  • Thair SA, Walley KR, Nakada TA, McConechy MK, Boyd JH, Russell JA. A single nucleotide polymorphism in NF-kB inducing kinase is associated with mortality in septic shock. J Immunol. 15;186(4):2321-2328, 2011.
  • Nakada TA, Russell JA, Wellman H, Boyd JH, Nakada E, Thain KR, Thair SA, Hirasawa H, Oda S, Walley KR. Leucyl/cystinyl aminopeptidase gene variants in septic shock. Chest, 139;1042-1049, 2011.
  • Nakada TA, Russell JA, Boyd JH, McLaughlin L, Nakada E, Thair SA, Hirasawa H, Oda S, Walley KR. Association of angiotensin II type 1 receptor-associated protein (AGTRAP) gene polymorphism with increased mortality in septic shock. Crit Care Med. 39(7):1641-1648, 2011.
  • Nakada E, Nakada T, Walley KR, McConechy M, McLaughlin L, von Dadelszen P, Shozub M, Boyd JH. mRNA induces RANTES production in trophoblast cells via TLR3 only when delivered intracellularly using lipid membrane encapsulation. Placenta. 32(7):500-505, 2011.
  • Millman AL, Payne B, Qu Z, Douglas MJ, Hutcheon JA, Lee T, Magee LA, Walley KR, von Dadelszen P. Oxygen saturation as a predictor of adverse maternal outcomes in women with preeclampsia. J Obstet Gynaecol Can. 33(7):705-714, 2011.
  • Sutherland AM, Walley KR, Nakada TA, Sham AHP, Wurfel MM, Russell JA. A Non-Synonymous Polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligands. J Innate Immun, 3(5):447-58, 2011.
  • Russell JA, Boyd JH, Nakada T, Thair SA, Walley KR. Molecular mechanisms of sepsis. Contrib Microbiol. 17:48-85, 2011.
  • Mehta S, Granton J, Lapinsky S, Newton G, Bandayrel K, Little A, Cook DJ, Ayers D, Singer J, Lee TCK, Walley KR, Storms M, Cooper KJ, Holmes CL, Hebert P, Gordon AC, Presneill J, Russell JA, for the VASST Investigators. Agreement in ECG interpretation in patients with septic shock. Crit Care Med. 39(9):2080-2086, 2011.
  • Scott Budinger GR, Walley KR. Predicting mortality in patients with acute lung injury. Am J Respir Crit Care Med. 184(4), 394-395, 2011.
  • Vincent JL, Rhodes A, Perel A, Martin GS, Rocca GD, Vallet B, Pinsky MR, Hofer CK, Teboul JL, de Boode WP, Scolletta S, Vieillard-Baron A, De Backer D, Walley KR, Maggiorini M, Singer M. Clinical review: Update on hemodynamic monitoring – a consensus of 16. Crit Care 15(4):229, 2011.
  • Mathur S, Walley KR, Wang Y, Indrambarya T, Boyd JH. Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2. Circ J. 75(10):2445-52, 2011.
  • Mathur. S, Walley KR, Boyd JH. The TLR9 ligand CpG-C attenuates acute inflammatory cardiac dysfunction. Shock. [Epub ahead of print, Sep 7, 2011].
  • Nakada T, Russell JA, Boyd JH, Walley KR. IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis. Crit Care In Press, 2011.
  • Walley KR. Shock. In: Principles of Critical Care, 4th Edition. JB Hall and GA Schmidt, Editors. McGraw Hill Publishers, New York, NY, 2011, in press.
  • Walley KR. Ventricular dysfunction in critical illness. In: Principles of Critical Care, 4th Edition. JB Hall and GA Schmidt, Editors. McGraw Hill Publishers, New York, NY, 2011, in press.
  • Manocha S, Walley KR. Adjunctive Respiratory Therapy. In: Textbook of Critical Care, 6th Edition. Vincent J-L, Abraham E, Moore FA, Kochanek PM, Fink MP, Editors, Elsevier Saunders, USA, 2011, pp 364-368.
Awards & Recognition:
  • 2003-2008 Distinguished Scholar, Michael Smith Foundation
  • 2009 Chaire Internationale, Universite Libre de Bruxelles.
  • 2010 Izaak Walton Killam Memorial Fund Research Prize