Position:
Clinical Associate Professor, UBC
Medical Director, Heart Transplant and MCS
Associate Program Director, UBC Postgraduate Cardiology Training
Program Director, Advanced Heart Failure/Transplant Training
Division:
Cardiology
Research Interests:

Dr. Toma’s research interests include outcomes research in heart failure, heart transplantation and mechanical circulatory support. He also has an active interest in biomarkers research and he has been involved with the PROOF Centre of Excellence for the Prevention of Organ Failures working on identifying biomarker panels for the diagnosis and prediction of numerous processes as they relate to acute and chronic heart failure, as well as cardiac transplantation.

Education:
MD, University of British Columbia (1999-2003)
MSc, Harvard School of Public Health (2010-2013)
Internal Medicine Residency, University of Alberta (2003-2006)
Cardiology Residency, University of Alberta (2006-2009)
Advanced Heart Failure and Heart Transplantation, Cleveland Clinic (2009-2010)
Recent Publications:
  • Interdisciplinary approach to an unusual case of myocarditis in pregnancy. Aude Marceau, Justin M.McGinnis, Fatemeh Derakhshan, Yi Ariel Liu, Gnalini Sathananthan, Ana Clara Sosa Cazales, Jasmine Grewal, Andrew Ignaszewski, Elisabet Joa, Michael Luong, Mustafa Toma, Sean A. Virani, Michael A. Seidman. CJC Open. https://doi.org/10.1016/j.cjco.2019.02.001
  • The Relationship Between Heart Failure Hospitalization and Mortality in Patients Receiving Transcatheter Aortic Valve Replacement.
    Hamed Nazzari, MD, PhD, Nathaniel M. Hawkins, MD, Justin Ezekowitz, MBBCh, MSc, Sandra Lauck, PhD, Lillian Ding, PhD, Jopie Polderman, BSc, Maggie Yu, BSc, Robert H. Boone, MD, Anson Cheung, MD, Jian Ye, MD, David Wood, MD, John Webb, MD, Mustafa Toma, MD, MSc
    DOI: https://doi.org/10.1016/j.cjca.2018.11.016
  • Mechanical circulatory support in the heart failure population.
    Nazzari H, Chue CD, Toma M.
    Curr Opin Cardiol. 2019 Jan 9. doi: 10.1097/HCO.0000000000000600. [Epub ahead of print]
    PMID: 30633077
  • The Impact of Left Ventricular Assist Device Infections on Postcardiac Transplant Outcomes: A Systematic Review and Meta-Analysis.
    Chahal D, Sepehry AA, Nazzari H, Wright AJ, Toma M.
    ASAIO J. 2019 Jan 4. doi: 10.1097/MAT.0000000000000921. [Epub ahead of print]
    PMID: 30575630
  • Rationale and design of the Study of Dietary Intervention Under 100 MMOL in Heart Failure (SODIUM-HF). Colin-Ramirez E, Ezekowitz JA; SODIUM-HF investigators. Am Heart J. 2018 Nov;205:87-96. doi: 10.1016/j.ahj.2018.08.005. Epub 2018 Aug 16.
  • Eligibility for cardiac resynchronization therapy in patients hospitalized with heart failure
    Joanna Osmanska, Nathaniel M. Hawkins, Mustafa Toma, Andrew Ignaszewski, Sean A. Virani
    ESC Heart Fail. 2018 Aug; 5(4): 668–674. Published online 2018 Jun 25. doi: 10.1002/ehf2.12297
    PMCID: PMC6073034
  • Heart Transplantation for End-Stage Cardiac Sarcoidosis: Increasingly Used With Excellent Results. Toma M, Birnie D. Can J Cardiol. 2018 Aug;34(8):956-958. doi: 10.1016/j.cjca.2018.04.018.
  • Palliative Care in Heart Failure: Review. Katie Wiskar, M Toma, Barret Rush. Trends in Cardiovascular Medicine. 2018 Feb 21. pii: S1050-1738(18)30031-8. doi: 10.1016/j.tcm.2018.02.008. [Epub ahead of print] Review.PMID: 29735287
  • Update on the management of acute heart failure.
    Rayner-Hartley E, Virani S, Toma M.
    Curr Opin Cardiol. 2018 Mar;33(2):225-231. doi: 10.1097/HCO.0000000000000485.
  • Differentiating heart failure phenotypes using sex-specific transcriptomic and proteomic biomarker panels. Toma M, Mak GJ, Chen V, Hollander Z, Shannon CP, Lam KKY, Ng RT, Tebbutt SJ, Wilson-McManus JE, Ignaszewski A, Anderson T, Dyck JRB, Howlett J, Ezekowitz J, McManus BM, Oudit GY.
    ESC Heart Fail. 2017 Aug;4(3):301-311. doi: 10.1002/ehf2.12136. Epub 2017 Mar 4.
    PMID:28772032
  • Barriers to Goals of Care Discussions With Patients Who Have Advanced Heart Failure: Results of a Multicenter Survey of Hospital-Based Cardiology Clinicians. You JJ, Aleksova N, Ducharme A, MacIver J, Mielniczuk L, Fowler RA, Demers C, Clarke B, Parent MC, Toma M, Strachan PH, Farand P, Isaac D, Zieroth S, Swinton M, Jiang X, Day AG, Heyland DK, Ross HJ.
    J Card Fail. 2017 Jun 23. pii: S1071-9164(17)30188-4. doi: 10.1016/j.cardfail.2017.06.003. [Epub ahead of print]
    PMID: 28648852
  • The Use of Text Messaging to Improve the Hospital-to-Community Transition in Acute Coronary Syndrome Patients (Txt2Prevent): Intervention Development and Pilot Randomized Controlled Trial Protocol. Ross ES, Sakakibara BM, Mackay MH, Whitehurst DG, Singer J, Toma M, Corbett KK, Van Spall HG, Rutherford K, Gheorghiu B, Code J, Lear SA. JMIR Res Protoc. 2017 May 23;6(5):e91. doi:10.2196/resprot.6968 URL: http://www.researchprotocols.org/2017/5/e91
  • Transapical mitral valve implantation after unclipping of a MitraClip: a glimpse into the future and treatment considerations in mitral regurgitation. Dvir D, Cheung A, Boone R, Leipsic J, Blanke P, Perlman G, Moss R, Toma M, Stub D, Banai S, Webb J.EuroIntervention. 2016 Jun 12;12(2):e244-9. doi: 10.4244/EIJV12I2A38.
  • Enumerateblood – an R package to estimate the cellular composition of whole blood from Affymetrix Gene ST gene expression profiles. Shannon CP, Balshaw R, Chen V, Hollander Z, Toma M, McManus BM, FitzGerald JM, Sin DD, Ng RT, Tebbutt SJ. BMC Genomics. 2017 Jan 6;18(1):43. doi: 10.1186/s12864-016-3460-1.
    PMID: 28061752
  • Differentiating heart failure with preserved and reduced ejection fraction through sex-specific transcriptomic and proteomic biomarker panels. MUSTAFA TOMA, George J Mak, VIRGINIA CHEN, ZSUZSANNA HOLLANDER, Casey Shannon (11 more) DOI:10.1002/ehf2.12136 (In-press)
  • Evaluation of a National Organ Sharing Policy for Highly Sensitized Patients Listed for Heart Transplantation in Canada. B. Clarke, A. Ducharme, N. Giannetti, D. Kim, M. McDonald, O. Kiamanesh, P. Pflugfelder, M. Rajda, M. Senechal, E. Stadnick, M. Toma, S. Zieroth, D. Isaac. J Heart Lung Transplant. 2017 Jan 6. pii: S1053-2498(17)30010-4. doi: 10.1016/j.healun.2017.01.003
  • Meta-Analysis of the Effectiveness of Heart Transplantation in Patients With a Failing Fontan. Tabarsi N, Guan M, Simmonds J, Toma M, Kiess M, Tsang V, Ruygrok P, Konstantinov I, Shi W, Grewal J. Am J Cardiol. 2017 Jan 25. pii: S0002-9149(17)30040-1. doi: 10.1016/j.amjcard.2017.01.001
  • Ranolazine for refractory angina in a heart transplant recipient with cardiac allograft vasculopathy.
    Yeung DF, Toma M, Davis MK, Ignaszewski A. Am J Transplant. 2016 Dec 30. doi: 10.1111/ajt.14190. [Epub ahead of print] PMID: 28035732