Infectious Diseases
Research Interests:

Microbial and viral pathogenicity.  Molecular genetics of microorganisms. Identification of targets for drug design.  Bioterrorism.

Recent Publications:
  • Bach, H., Sun, J., Wong , D., Hmama, Z. and Av-Gay Y. (2006), Mycobacterium avium ssp paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection. Infection and Immunity. 4:6540-6546.
  • Newton GL, Koledin T, Ko M, Av-Gay Y, Fahey RC (2006). N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-D-glucopyranoside Deacetylase, a Mycothiol Biosynthetic Enzyme (MshB), is a metalloprotein subject to feedback inhibition by Mycothiol. Protein Expression and Purification. 47:542-550.
  • Pérez, J., Garcia, R. L., Bach, H., H de Waard, J., Jacobs, W. R. Jr., Av-Gay, Y., Bubis, J and Takiff H. (2006). Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD. BBRC. 348:6-12.
  • Pick N, Rawat M, Arad D, Lan J, Fan J, Kende AS, Av-Gay Y. (2006). In Vitro Properties of Antimicrobial Bromo-Tyrosine Alkaloids, J Med. Micro. 55: 407-415.
  • Ung S.E.K,, and Av-Gay, Y. (2006). Mycothiol Dependent Mycobacterial Response to Oxidative Stress. FEBS Letters. 580:2712-2716.
  • Deghmane AE, Soualhine H,Bach, H., Sendide K, Itoh S, Tam A, Noubir S, Talal A, Lo R, Toyoshima S, Av-Gay Y, Hmama Z. (2007). LpdC mediates retention of coronin-1 on M. bovis BCG vacuoles, leading to arrest in phagosome maturation. J. Cell Sci. 120(16):2796-2806.
  • Mamta Rawat and and Yossef Av-Gay. (2007). Mycothiol dependent Proteins in Actinomycetes.  FEMS Microbiology Reviews. 31:278-292.
  • Miller,C. C. Rawat, M.,  Johnson, T., and Av-Gay, Y. (2007). Innate Protection of Mycobacteria Against the Antimicrobial Activity of Nitric Oxide is Provided by Mycothiol. Anti Microbial Agents and Chemotherapy, 51(9):3364-3366.
  • Rawat, M., Johnson, T., Cadiz, V., and Av-Gay Y. (2007). Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis. BBRC. 363:71-76.
  • Soualhine H, Deghmane AE, Mak K, Amina Talal A, Av-Gay Y, Hmama Z. (2007). Recombinant Mycobacterium bovis BCG secreting cathepsin S promotes MHC class II-directed antigen presentation by the macrophage cell line THP-1. J Immunol .179:5137-5145.
  • Zheng, X., Papavinasasundaram, K.G., and Av-Gay, Y. (2007), Novel Substrates of Mycobacterium tuberculosis PknH serine / Threonine Kinase. BBRC. 355:162-168.
  • Bach H, Papavinasasundaram KG, Wong D, Hmama Z, and Av-Gay Y. (2008). Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of Human VPS33B. Cell: Host & Microbe. 3(5):316-22.
  • Gopalasawamy, R., Naryanan, S., Jacobs. W.R., Jr., Ko, M., and Av-Gay, Y. (2008). Protein kinase MSMEG3682 from M. smegmatis is essential for maintenance of cell wall architecture and cell division. FEMS Microbiology Letters. 278:121-127.
  • Hegymegi-Barakonyi B, Székely R, Varga Z, Kiss R, Borbély G, Németh G, Bánhegyi P, Pató J, Greff Z, Horváth Z, Mészáros G, Marosfalvi J, Eros D, Szántai-Kis C, Breza N, Garavaglia S, Perozzi S, Rizzi M, Hafenbradl D, Ko M, Av-Gay Y, Klebl BM, Orfi L, Kéri G. (2008). Signalling Inhibitors Against Mycobacterium tuberculosis – Early Days of a New Therapeutic Concept in Tuberculosis. Curr. Med. Chem. 15(26):2760-70.
  • Narayan HL, Naryanan S, Bach H, Papavinasasundaram KG, and Av-Gay Y. (2008). Molecular cloning and biochemical characterization of a serine threonine protein kinase, PknL, from Mycobacterium tuberculosis. Protein Expression and Purification. 58(2):309-17.
  • Vilcheze C, Av-Gay Y, Attarian R, Liu Z, Hazbón MH, Colangeli R, Chen B, Liu W, Alland D, Sacchettini JC, Jacobs Jr WR. (2008). Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis. Molecular Microbiology. 69(5):1316-29.
  • Attarian, R., Bach, H., Bennie, C., and Av-Gay, Y. (2009). Glutathione Disulfide and S-Nitrosoglutathione Detoxification by Mycobacterium tuberculosis Thioredoxin System.  FEBS Letters. 583: 3215-3220.
  • Bach, H. Wong, D. and Av-Gay, Y. (2009). Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA. Biochem J. 420:155-160.
  • Chao, D. J.,  Wong, D., Zheng, X., Poirier, V., Bach, H., Hmama. Z., and Av-Gay, Y. (2009). Protein kinases and phosphatases signaling in Mycobacterium tuberculosis physiology and pathogenesis. Biochimica et Biophysica Acta – Proteins and Proteomics. (Review). In press.
  • Gopalasawamy, R., Narayanan, S., Chen, B., Jacobs, W. R., and Av-Gay, Y. (2009). The serine/threonine kinase PknI controls the growth of Mycobacterium tuberculosis upon infection. FEMS microbiology Letters. 295:23-29.
  • Miller CC, McMullin B, Ghaffari A, Pick N, Roscoe D, Road J, Ghahary A, and Av-Gay Y. (2009). Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure. Nitric Oxide 20(1):16-23.
  • Bach MS., Fortuna MA., Attarian R., de Trimarco JT, Catalan CAN., Av-Gay. Y. and Bach, H., (2010). Antibacterial and Cytotoxic Activities of the Sesquiterpene Lactones Cnicin and Onopordopicrin. Natural. Prod. Comm. 5:  1-4.
  • Borrelli S, Zandberg WF, Mohan S, Ko M, Martinez-Gutierrez F, Partha SK, Sanders DA, Av-Gay Y, Pinto BM. (2010). Antimycobacterial activity of UDP-galactopyranose mutase inhibitors. Int J Antimicrob Agents. 36(4):364-368.
  • Chao JD, Papavinasasundaram KG, Zheng X, Chávez-Steenbock A, Wang X, Lee GQ, Av-Gay Y. (2010). Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis. J Biol Chem. 285(38):29232-29246.
  • Deshayes C, Bach H, Euphrasie D, Attarian R, Coureuil M, Sougakoff W, Laval F, Av-Gay Y, Daffé M, Etienne G, Reyrat JM. (2010). MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis. Mol Microbiol. 78(4):989-1003.
  • Martinez-Gutierrez. F., Olive, P., Banuelos, A., Nino, N., Ruiz, F., Bach, H., and Av-Gay. Y. (2010). Synthesis, characterization and evaluation of antimicrobial and cytotoxic effect of silver and titanium nano-particles. Nanomedicine. 6: 681-688.
  • Mascarello A, Chiaradia LD, Vernal J, Villarino A, Guido RV, Perizzolo P, Poirier V, Wong D, Martins PG, Nunes RJ, Yunes RA, Andricopulo AD, Av-Gay Y*, Terenzi H. (2010). Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth. Bioorg Med Chem. 18(11):3783-9. (* Co-corresponding authors).
  • Movahedzadeh F, Wheeler PR, Dinadayala P, Av-Gay Y, Parish T, Daffe M, Stoker N (2010). Inositol monophosphate phosphatase genes of mycobacterium tuberculosis. BMC Microbiology. 18;10:50.
  • Regev-Shoshani, G., M. Ko, Miller C. C., and Av-Gay, Y. (2010). The slow release of Nitric Oxide from charged catheter and its effect on Biofilm formation by Escherichia coli.  Antimicrob Agents Chemother. 54:273-279.