Position:
Assistant Professor
Cardiac Electrophysiologist
Address:
220-1033 Davie St.
Vancouver, British Columbia V6E 1M7
Canada
Research Interests:
  • Arrhythmias
  • cardiogenetics
  • stem cell disease modelling
  • wearable technology
Research Summary:

Dr. Laksman’s research spans the breadth of clinical and basic science discovery and innovation in the fields of cardiogenetics, stem cell disease modeling and drug screening. He is a clinical cardiac electrophysiologist at St. Paul’s hospital and has close relationships and affiliations with UBC, SFU, and BC Children’s hospital. Ongoing research studies include the genetic causes of atrial fibrillation and sudden cardiac death, human induced pluripotent stem cell disease modeling of cardiac disease, and employing stem cell derived cardiomyocytes for high throughput drug screening.

Education:
University of Toronto, BSc, Human Biology
University of Toronto, MD
University of Toronto, FRCPC, Internal Medicine
University of Toronto , FRCPC, Cardiology
Western University, Electrophysiology Clinical and Research Fellowship
University of Toronto, MSc
McEwen Centre, University Health Network, Clinical Fellow in Cardiac Regenerative Medicine
Affiliations
Centre for Heart Lung Innovation, UBC and St. Paul’s Hospital, Early Career Investigator
UBC Department of Medicine, Experimental Medicine, Faculty
Simon Fraser University, Adjunct Professor
Michael Smith Foundation for Health Research, Profession-Investigator
Inherited Arrhythmia Clinic, St. Paul’s Hospital, , Director
Atrial Fibrillation Clinic, St. Paul’s Hospital, Director
Recent Publications:

Walia, J., Steinberg, C., Laksman, Z. Brugada Syndrome: Updated 2019
Perspectives. Research Reports in Clinical Cardiology. Accepted.

Laksman, Z, Barichello, S, Roston, T, Deyell, M, Krahn, AD. Acute Arrhythmia 2019
Management in Patients with Suspected Inherited Heart Rhythm Disorders.
Journal of the American College of Cardiology: Clinical Electrophysiology.
Epub March.

Shafaattalab, S, Li, Y, Lin, E, Stevens, C, Dewar, L, Lynn, F, Sanatani, S, 2019
Laksman, Z, Tieleman, D, Davis, J, Tibbits, G. Arrhythmogenic thin filament
variants as a cause of sudden cardiac death in infants: In vitro analyses
to determine pathogenicity Proceedings of the National Academy of Sciences.
Accepted.

Deyell MW, Wen G, Laksman Z, Bennett MT, Chakrabarti S, Yeung-Lai-Wah 2019
JA, Krahn AD, Andrade JG. The impact of steerable sheaths on unblinded
contact force during catheter ablation for atrial fibrillation. J Interv Card
Electrophysiol. Jan 20.Epub.

Malhi, N, So, P, Cheung, C, Laksman, Z, Healey, J, Chauhan, V, Green, M, 2018
Champagne, J, Steinberg, C, Sanatani, S, Angaran, P, Duff, H, Roberts, J,
Arbour, L, Leather, R, Simpson, C, Tadros, R, Talajic, M, Gardner, M, Seifer,
C, Krahn, AD. Early repolarization inheritance in the cardiac arrest survivors
with preserved ejection fraction registry (CASPER). JACC EP. Nov;4(11):
1473-1479.

Roston, TM, Jones, K, Hawkins, NM, Bos, JM, Schwartz, PJ, Perry, F, 2018
Ackerman, MJ, Laksman, Z, Kaul, P, Lieve, KVV, Atallah, J, Krahn, AD
Sanatani, S. Implantable cardioverter-defibrillator use in catecholaminergic
Polymorphic ventricular tachycardia: A systematic review. Heart Rhythm.
Dec;15(12):1791-1799.

Barichello, S, Roberts, J, Backx, P, Boyle, P, Laksman, Z. Personalizing 2018
Therapy for Atrial Fibrillation: the Role of Stem Cells and in Silico
Disease Models. Cardiovascular Research. Jun 1;114(7):931-943
Janze, M, Malhi, N, Laksman, Z, Krahn, A, Hawkins, N. The 2018
QT interval in anorexia nervosa: a systematic review and metaanalysis.
JACC EP. Jun;4(6):839-841.

Roston, TM, Deward, L, Franciosi, S, Hathaway, J, Bartels, K, 2018
Cunninghamn, T, Gibbs, KA, Sheps, S, Laksman, Z, Sanatani, S, Krahn,
AD. The accessibility and utilization of genetic testing for inherited heart
rhythm disorders: a Canadian cross-sectional survey study.
J Community Genet. Jul;9(3):257-262.

Halperin, L, Mellor, G, Talajic, M, Krahn, A, Tadros, R, Laksman, Z. 2018
Quinidine Effective for Management of Ventricular and Atrial
Arrhythmias associated with Brugada Syndrome. Heart Rhythm Case Reports.
Apr 30;4(7):270-272.

Zachary Laksman M.D., Marianne Wauchop B.Sc., Eric Lin Ph.D., 2017
Stephanie Protze Ph.D., Jeehoon Lee B.Sc., Wallace Yang P.Eng.,
Farzad Izaddoustdar M.Sc., Sanam Shafaattalab B.Sc.,
Lior Gepstein M.D., Ph.D., Glen F Tibbits Ph.D., Gordon Keller Ph.D.,
Peter H Backx Ph.D., DVM. Modeling Atrial Fibrillation using Human
Embryonic Stem Cell-Derived Atrial Tissue. Scientific Reports.
Jul 13;7(1):5268.

Jeehoon Lee, Stephanie I Protze, Zachary Laksman, Peter H. Backx, 2017
Gordon M Keller. The atrial and ventricular cardiomyocyte lineages
derive from distinct mesodermal progenitors that are specified by
gradients of BMP and Activin A signalling. Cell Stem Cell.
Aug 3;21(2):179-194

Greg Mellor, Zachary WM Laksman, Rafik Tadros, Jason D. Roberts, 2017
Brenda Gerull, Christopher S. Simpson, George Klein, Jean Champagne,
Mario Talajic, Martin Gardner, Christian Steinberg, Laura Arbour, David H.
Birnie, Paul Angaran, Richard Leather, Shubhayan Sanatani,Vijay S.
Chauhan, Colette Seifer, Jeffrey S. Healey, Andrew D. Krahn. Genetic
Testing in the Evaluation of Unexplained Cardiac Arrest: From the Cardiac
Arrest Survivors with Preserved Ejection Fraction Registry. Circulation:
Cardiovascular Genetics. Jun;10(3).

Thomas M. Roston, Taylor Cunningham, Anna Lehman, Zachary W. 2017
Laksman, Andrew D. Krahn, Shubhayan Sanatani.Beyond the
Electrocardiogram: Mutations in Cardiac Ion Channel Genes Underlie
Nonarrhythmic Phenotypes. Clinical Medicine Insights: Cardiology.
Mar 16;11

Krahn AD, Healey JS, Gerull B, Angaran P, Chakrabarti S, Sanatani S, 2016
Arbour L, Laksman ZW, Carroll SL, Seifer C, Green M, Roberts JD,
Talajic M, Hamilton R, Gardner M. The Canadian Arrhythmogenic Right
Ventriculr Cardiomyopathy Registry: Rationale, Design, and Preliminary
Recruitment. Can J Cardiol. Dec;32(12):1396-1401

Steinberg C, Padfield GJ, Al-Sabeq B, Adler A, Yeung-Lai-Wah JA, 2016
Kerr CR, Deyell MW, Andrade JG, Bennett MT, Yee R, Klein GJ,
Green M, Laksman ZW, Krahn AD, Chakrabarti S. Experience with
Bisoprolol in long-QT1 and long-QT2 syndrome. J Interv Card
Electrophysiol. Nov;47(2):163-170. 2016

Steinberg C, Laksman ZW, Krahn AD. Sudden Cardiac death: A 2016
Reappraisal. Trends Cardiovasc Med. Nov;26(8): 709-719.

Laksman, Z. Update on Atrial Fibrillation. Canadian Journal of CME. 2016
October.

Mellor G, Steinberg C, Laksman Z, Deyell MW. Short-Coupled Ventricular 2016
Fibrillation. J Cardiovasc Electrophysiol. Oct;27 (10):1236-1237.

Cheung CC, Laksman ZW, Mellor G, Sanatani S, Krahn AD. Exercise and 2016
Inherited Arrhythmias. Can J Cardiol. Apr;32(4):452-8.

Laksman, ZW, Krahn, AD. Fast and Spurious; Correcting the QT interval. 2016
Heart Rhythm. Feb;13(2):536-7.

Liu J, Laksman Z, Backx PH. The electrophysiological development of 2016
Cardiomyocytes. Adv Drug Deliv Rev. Jan 15;96:253-73.

Holmes, JW, Laksman, Z, Gepstein, L. Making better scar: Emerging 2016
Approaches for modifying mechanical and electrical properties following
Infarction and ablation. Prog Biophys Mol Biol. Jan;120(1-3):134-48.

Hanninen M, Klein GJ, Laksman Z, Conacher SS, Skanes AC, Yee R, 2015
Gula LJ, Leong-Sit P, Manlucu J, Krahn AD. J Genet Couns.
Aug;24(4):558-64.

Laksman, Z, Momciu, B, Conacher, S, Burrows, P, Skanes, AC, 2015
Yee, R, Gula, LJ, Leong-Sit, P, Manlucu, J, Klein, GJ, Krahn, AD.
Hospital Recorded QT Prolongation: A Detailed Description And
Assessment of Outcomes. The American Journal of Cardiology.
Apr 1;115(7):907-11.

Cassagneau R, Hanninen M, Laksman Z, Manlucu J, Yee R. An 2015
“irritating” magnet test. Pacing Clin Electrophysiol. Jan;38(1):151-2.

Laksman, Z, Burrows, P, Nevis, I, Skanes, AC, Yee, R, Gula, LJ, 2014
Leong-Sit, P, Manlucu, J, Klein, GJ, White, J. Model-based navigation
of left and right ventricular leads to optimal targets for cardiac
resynchronization therapy.Circulation: Arrhythmia and Electrophysiology.
Dec; 7(6):1040-7.

Laksman, Z, Dulay, D, Gollob, M, Skanes, A, Krahn, A. Evolution of a 2014
Genetic Diagnosis. Clinical Genetics. Dec; 86(6):580-4.

Laksman, Z, Gula, LJ, Saklani, P, Cassagneau, R, Yee, R, Skanes, A, 2014
Leong-Sit, P, Manlucu, J, Klein, G, Krahn, A. Early Repolarization is a
Cofactor Predicting Risk of Symptoms in Patients with
Long QT Syndrome. Heart Rhythm.Sep;11(9):1632-8.

Laksman, Z, Krahn, A, Dorian, P, Simpson, C, Crystal, E, Healey, J, 2014
Khaykin, Y, Wang, X, Lee, DS. Higher Mortality Risk Among Patients
with Delayed Follow-up After Implantable Cardioverter Defibrillator
Procedures. Canadian Journal of Cardiology. Jun;30(6):598-605.

Al-Sabeq, B, Conacher, S, Krahn, A, Klein, G, and Laksman, Z. ARVC 2014
with recessive inheritance related to a new homozygous desmocollin-2
mutation. Canadian Journal of Cardiology. Jun;30(6):696.

Laksman, Z, Klein, G. Cryptogenic Stroke, when and how you should 2014
look for arrhythmias. Cardiac Electrophysiology Clinics. Mar;6(1) :161-7.

Laksman, Z, Skanes, AC, Klein, G, Manlucu, J. Dual atrial tachycardia 2013
in a transplant heart– when is “in” really “out”? Journal of
Cardiovascular Electrophysiology. Dec;24(12):1428-31.

Perrin, MJ, Angaran, P, Laksman, Z, Zhang, H, Porepa, L, Rutberg, J, 2013
James, C, Krahn, A, Judge, D, Calkins, H, Gollob, MH. Exercise Testing
in Asymptomatic Gene Carriers Exposes a Latent Electrical Substrate of
Arrhythmogenic Right Ventricular Cardiomyopathy. Journal of American
College of Cardiology. Nov 5;62(19):1772-9.

Laksman, Z, Hamilton, R, Chockalingam, P, Wilde, A, Ballantyne, E, 2013
Stephenson, E, Gross, G, Gula, L, Klein, G, Krahn, A. Does Mutation
Affect Severity of Phenotype in Type 1 Long QT Syndrome? Impact of
Transmembrane and c-Loop location. Journal of Cardiovascular
Electrophysiology. Sep;24(9):1015-20

Laksman ZW, Silversides CK, Sedlak T, Samman AM, Williams WG, 2011
Webb GD, Liu PP. Valvular aortic stenosis as a major sequelae in patients
with pre-existing subaortic stenosis; changing spectrum of outcomes.
Journal of American College of Cardiology. Aug 23;58 (9):962-5.

Laksman, Z, Harris, L, Silversides, C. Arrhythmias in Pregnancy, a 2011
Review. Fetal and Maternal Medicine Review. May (22):2;123-143.

Laksman, Z and Detsky, A. Personalized Medicine: Understanding 2011
Probabilities and Managing Expectations. Journal of General Internal
Medicine. Feb (2):204-6.

Laksman, Z, Kane, G, Murphy, J. Thrombolytic Therapy for Late 2008
Thrombosis of a Bioprosthetic Mitral Valve: Atypical Diagnostic
Echocardiographic Features and Literature Review. Journal of Heart
Valve Disease. Nov;17(6):670-3.

Awards & Recognition:
  • Charles Kerr Distinguished Scholar in Cardiovascular Genetics
  • First Prize, Alan Wu Competition, Institute of Medical Sciences, School of Graduate Studies
    University of Toronto, 2015
  • Most Innovative Research Award, Cardiovascular Sciences Collaborative Program,
    School of Graduate Studies, University of Toronto, 2015
  • Eliot Phillipson Clinician Scientist Training Award, University of Toronto, 2014
  • First Prize, Case Challenge, Winter Arrhythmia Update, Whistler BC, 2014
  • Heart & Stroke/Richard Lewar Centre of Excellence Fellowship Award, 2013
  • First place, Resident Research Day, Division of Cardiology, Western University, 2013
  • Resident Research Career Development Award, Department of Medicine, Western University, 2013
  • Outstanding Resident of the Year, Internal Medicine, University Health Network, University of Toronto, 2008
  • Canadian Foundation for Innovation
    Title: High throughput screening using stem cell derived cardiomyocytes
  • Stem Cell Network-Clinical Translation & Accelerator Impact grant
    Title: Testing novel compounds for atrial fibrillation
  • Canadian Cardiovascular Society-Bayer National Resident Vascular Award
    Title: CRAVE AF
  • Canadian Institutes of Health and Research Operating Grant
    Title: Risk prediction of sudden death in arrhythmogenic right ventricular cardiomyopathy: the Canadian ARVC registry
  • Canadian Institutes of Health and Research Operating Grant
    Title: Investigating drug therapies for inherited and acquired long QT syndrome using iPSC-derived cardiomyocytes and zebrafish whole hearts as translational models
  • Canadian Institutes of Health and Research Operating Grant
    Title: Arrhythmogenic mutations in the neonate cardiac contractile element.
  • Michael Smith Foundation for Health Research- Professional Investigator Award
  • Canadian Institutes of Health and Research Operating Grant
    Title: Investigating Pharmacogenetic Mechanisms of Doxorubicin-Induced Cardiotoxicty in Human Pluripotent Stem Cell-Derived Cardiomyocytes
  • Cardiology Academic Practice Plan Pilot Project
    Title: Studying post-translational modification in atrial fibrillation using human atrial samples
  • Canadian Institutes of Health and Research Operating Grant
    Title: Familial hypertrophic cardiomyopathy: etiology involving troponin mutations
  • Canadian Cardiovascular Society-Atrial Fibrillation Research Award
    Title: PERSONALIZE AF
  • Canadian Institutes of Health and Research Operating Grant – MOP-84524
    Title: Next generation arrhythmia modeling: the role of pluripotent stem
    cells and the future of personalized medicine
  • Canadian Institutes of Health and Research Operating Grant
    Title: Impact of early repolarization on Long QT syndrome: Canadian Genetic Heart Rhythm Network
  • UBC, Cardiovascular Pathophysiology 570, Lecturer
  • UBC, Cardiology Residents, Lecturer

 

Students

  • Co-supervisor to 1 PhD student
  • Co-supervisor to 4 MSc students
  • Supervisor to 12 medical students/residents/fellows