My goal is to determine the role of nitric oxide as a first line antimicrobial agent for use in infectious diseases in order to reduce the use of antibiotics.
Antimicrobial role of nitric oxide
• Antibiotic resistance associated with M. tuberculosis, S. aureus, P. aeruginosa
• Role of nitric oxide in non-healing wounds and cystic fibrosis
• Therapeutic use of nitric oxide in Avian flu and parasitic infections
• Inhaled nitric oxide for treatment of cerebral malaria ( www.inouganda.com )
• Tumorcidal activity of nitric oxide
• Ventilator acquired pneumonia
Dr. Miller’s research is to ultimately determine the antimicrobial role of nitric oxide for potential as a first line treatment for infections such as tuberculosis, malaria, leishmaniasis, cystic fibrosis, bovine respiratory disease and viral pandemics.
Scouts Canada Sponsor Representative, LDS Youth Group Mentor
Hawkes M, Robert, Opoka RO, Namasopo S, Miller C,Thorpe KE, Lavery JV, Conroy AL, Liles C, John CC, Kain KC. Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: Protocol for a Randomized Controlled Trial. Trials 2011;12(1):176-189.
Rezakhanloua, A, Miller C, McMullin B, Ghaffaria A, Ghaharya A. Gaseous Nitric Oxide Exhibits Does Not Effect Skin Fibroblast Extra Cellular Matrix Gene Expression and Immune Cell Viability. Cell Biol Int 2011;35:407-415.
Regev-Shoshani G , Ko M, Miller C, Av-Gay Y. The slow release of Nitric Oxide from charged catheter and its antimicrobial effect on Escherichia coli Antimicrobial Agents And Chemotherapy 2010;54(1):273-279.
Miller C, McMullin B, Ghaffari A, Miller J, Stenzler A, Pick N, Roscoe D, Ghahary A, Road J, Av Gay Y. Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure Nitric Oxide 2009;20 :16-23.
Trudell Award and Jimmy Schultz Award for his contributions for innovative use of respiratory technologies for patient care.