Position:
Professor
Division:
Hematology
Research Interests:

Delineating links between coagulation and innate immunity to identify novel sights for intervention; hemostasis-thrombosis.

Research Sumary:

Since inflammation and cancer are often associated with excess blood clotting, we aim to determine the mechanisms in the blood and on the blood vessel wall. This will allow the design of better therapies and preventative strategies to prevent thrombosis.

Education:
University of Leuven, Belgium, Phd
Heriot Watt University, Edinburgh, MBA
Diploma in Hematology, Harvard University
University of Toronto, FRCP(C) in Internal Medicine
University of Toronto, MD
Electrical Engineering, University of Toronto, BASc
Recent Publications:
  • Foley JH, Conway EM. Gas6 gains entry into the coagulation cascade. Blood 2012 In Press.
  • Foubert K, Breynaert A, Theunis M, Van Den Bossche R, De Meyer GR, Van Daele A, Faizal A, Goossens A, Geelen D, Conway EM, Vlietinck A, Pieters L, Apers S. Evaluation of the anti-angiogenic activity of saponins from Maesa lanceolata by different assays.Nature Prod Communications 2012 7(9):1149-54.
  • Wang H, Vinnikov I, He T, Zhou Q, Shahzad K, Ranjan S, Wolter J, Kashif M, Oh J, Kirschfink M, Bierhaus A, Nawroth P, Conway EM, Madhusudhan T, Isermann B.  The lectin-like domain of thrombomodulin ameliorates complement dependent diabetic nephropathy. Thromb Haemost 2012.108(6): EPub. PMID 23014597
  • Iscru E,a Ahmed T, Coremans V, Bozzi Y, Caleo M, Conway EM, D’Hooge R, Balschun D. Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1 region. Neuroscience 2012 In press.
  • Zoja C, Locatelli M, Pagani C, Corna D, Isermann B, Remuzzi G, Conway EM, Noris M. Lack of the lectin-like domain of thrombomodulin worsens shiga toxin-associated HUS in mice.  J. Immunology 2012. 189(7):3661-8.
  • Schouten M, de Boer JD, van t Veer C, Roelofs JJTH, Meijers JCM, Levi MM, Conway EM, van der Poll T. The lectin-like domain of thrombomodulin hampers host defense in pneumoccoccal pneumonia. Eur Resp J 2012. Aug 30. Epub PMID 22936703
  • Krisinger M, Goebeler V, Lu Z, Meixner SC, Myles T, Pryzdial ELG, Conway EM. Revising the terminal complement pathway: Thrombin generates previously unidentified C5 products which augment lytic activity. Blood 2012. 120(8):1717-25.
  • Conway EM.  Thrombomodulin and its role in inflammation.  Seminars Immunopath. 2012. 34(1):107-125.
  • Valdez Y, Maia M, Conway EM. CD248: Reviewing its role in health and disease.  Curr Drug Targets 2012. Mar;13(3):432-439
  • Conway EM. The Type XIV family of C-type lectin-like domain (CTLD) containing proteins.  Curr Drug Targets 2012. Mar;13(3):409-410
  • Martinez-Gutierrez F, Thi E, Silverman M, Camargo C, Svensson S, Vanden Hoek A, Reiner N, Gaynor E, Pryzdial ELG, Conway EM, Orrantia E, Ruiz F, Av-Gay Y, Bach H.  Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine Jun 27, 2012 8(3):328-336.
  • Conway EM. The clock is ticking as the clot is thickening.  Arterioscler Thromb Vasc Biology. 2011. 31(11):2361-3
  • Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KCS, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood 2011. 118(10):2889-95.
  • Maia M, DeVriese A, Janssens T, Moons M, Lories RJ, Tavernier J, Conway EM. CD248 facilitates tumor growth via its cytoplasmic domain.  BMC Cancer 2011, 11:162.
  • Takagi T, Taguchi O, D’Alessandro-Gabazza C, Toda M, Kobayashi T, Ruiz DB, Bernabe PG, Aoki S, Chiba F, Yano Y, Conway EM, Munesue S, Yamamoto Y, Yamamoto H, Suzuki K, Takei Y, Morser J, Gabazza EC. Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells. Am J Resp Critical Care Med 2011. 183(1):31-42.
  • Maia M, DeVriese A, Janssens T, Moons M, Van Landuyt K, Tavernier J, Lories RJ, Conway EM.  CD248 and its cytoplasmic domain: a therapeutic target for arthritis.  Arthritis & Rheumatism 2010. 62(12):3595-606.
  • Coremans V, Ahmed T, Balschun D, D’Hooge R, DeVriese A, Cremer J, Antonucci F, Moons M, Baekelandt V, Reumers V, Cremer H, Eisch A, Lagace D, Janssens T, Bozzi Y, Caleo M, Conway EM.  Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin.  BMC Neuroscience Jan 5;11(1):2, 2010.
  • Conway EM. Super factor B”-gets atypical HUS.  Blood 2009.  114(13):2572-4
  • Delvaeye M, Conway EM. Coagulation and innate Immune responses: Can they be viewed separately?  Blood 2009. 114(2):2367-74.
  • Delvaeye M, De Vriese A, Esmon CT, Esmon N, Ferrell G, Claes B, Lambrechts D, Remuzzi G, Noris M, Conway EM. Mutations in thrombomodulin in hemolytic-uremic syndrome. New England Journal of Medicine (IF 51) 361:345-357, 2009.
  • Delvaeye M, De Vriese A, , Zwerts F, Betz I, Moons M, Autiero M, Conway EM. Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis. BMC Developmental Biology 2009 Mar 26;9:25
  • Geudens N, Van de Wouwer M, Banaudenaerde BM, Vos R, Van De Wauwer C, Verleden GM, Verbeken E, Lerut T, Van Raemdonck DEM, Conway EM. The lectin-like domain of thrombomodulin protects against ischemia-reperfusion lung injury.  European Respiratory Journal, 2008, 32(4):862-70.
Awards & Recognition:

Tier 1 Canada Research Chair in Endothelial Cell Biology