Position:
Adjunct Professor
Division:
Infectious Diseases
Research Interests:

Microbial pathogenicity, Proteomics of host-pathogen interaction, Identification of targets for drug design, Nanomedicine, Natural compounds

Education:
Technion Institute, Biology, BSc
Technion Institute, Environmental Engineering, MSc
Recent Publications:

•Bach H*, Sun J, Hmama Z, Av-Gay Y. (2006). Mycobacterium avium subsp. paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection. Infect. Immun. 74:6540-6546. * Corresponding Author.
•Bach H, Gutnick DL. (2006). A unique polypeptide from the C-terminus of an esterase of Acinetobacter venetianus RAG-1 modulates the emulsifying activity of the bioemulsifier apoemulsan. Appl. Microbiol. Biotechnol. 71:177-183.
•Bach H, Gutnick DL. (2006). Novel Polysaccharide-Protein Based Amphipathic Formulations. Appl. Microbiol. Biotechnol. 71:34-38.
•Pérez J, Garcia R, Bach H, de Waard J, Jacobs W, Av-Gay Y, Bubis J, Takiff HE. (2006). Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD. Biochem. Biophys. Res. Commun. 348:6-12.
•Deghmane AE, Soulhine H, Bach H, Sendide K, Itoh S, Tam A, Noubir S, Talal A, Lo R, Toyoshima S, Av-Gay Y, Hmama Z. (2007). Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation. J. Cell Sci. 120:2796-2806.
•Bach H, Papavinasasundaram K, Wong D, Hmama Z, Av-Gay Y. (2008). Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of Human VPS33B. Cell Host and Microbe. 3:316-322.
•Lakshminarayan H, Narayanan S, Bach H, Sundaram KG, Av-Gay Y. (2008). Molecular cloning and biochemical characterization of a serine threonine protein kinase, PknL, from Mycobacterium tuberculosis. Prot. Expr. Purif. 58:309-317.
•Attarian R, Benny C, Bach H, Av-Gay Y. (2009). Glutathione disulfide and S-nitrosoglutathione detoxification by Mycobacterium tuberculosis thioredoxin system. FEMS Lett. 583:3215-3220.
•Bach H, Wong D, Av-Gay Y. (2009). Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA. Biochemical J. 420:155-160.
•Bach H*, Ko H, Attarian R, Raizman, EA, Cho B, Biet F, Enns R, Bressler B. (2010). Immunogenecity of Mycobacterium avium spp paratuberculosis proteins in Crohn’s disease patients. Scand. J. Gastroenterol. 46:30-39. * Corresponding Author.
•Bach SM, Fortuna AM, Attarian R, Trimarco JT, Catalan CAN, Av-Gay Y, Bach H*. (2010). Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin. Nat. Prod. Commun. 6:163-166. * Corresponding Author.
•Chao J, Wong D, Zheng X, Poirier V, Bach H, Hmama Z, Av-Gay Y. (2010). Protein kinases and phosphatases signaling in Mycobacterium tuberculosis physiology and pathogenesis. Bioch. Bioph. Acta: Proteins and Proteomics 1804: 620-627.
•Deshayes C, Bach H, Euphrasie D, Attarian R, Coureuil M, Sougakoff W, Laval F, Av-Gay Y, Daffe M, Etienne G, Reyrat JM. (2010). MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis. Mol. Microbiol. 79:989-1003.
•Martinez F, Olive P, Banuelos A, Orrantia E, Nino N, Ruiz F, Bach H*, Av-Gay Y. (2010). Synthesis, characterization and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles. Nanomedicine 6:681-688. * Corresponding Author.
•Bach SM, Diaz FR, Bach H, Catalan CAN. (2011). A facile and efficient four-step synthesis of vernolepin from minimolide, the major germacranolide of Mikania minima. Nat. Prod. Commun. 6:433-438.
•Bach SM, Perotti ME, Merep AP, Marcial GE, Grau A, Attarian R, Av-Gay Y, Bach H*, Catalan CAN. (2011). Chemical constituents, anti-inflammatory, and antioxidant activities of bark extracts from Prunus tucumanensis. Molecules (in review). * Corresponding Author.
•Bolivar P, Cruz-Paredes C, Hernandez LR, Juarez ZN, Sanchez-Arreola E, Av-Gay Y, Bach H*. (2011). Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum. J. Ethnopharmacol. 137: 141-147. * Corresponding Author.
•Fortuna AM, Juarez ZN, Bach H, Nematallah A, Av-Gay Y, Sanchez-Arreola E, Riscala E, Catalan C, Turbay S, Hernandez L. (2011). Sesquiterpene lactones and inositol derivatives from Hymenoxys robusta. Phytochemistry (Accepted).
•Martinez-Gutierrez F, Thi E, Silverman M, Camargo C, Svensson S, Vanden Hoek A, Reiner N, Gaynor E, Pryzdial E, Conway E, Orrantia, Ruiz F, Av-Gay Y, Bach H*. (2011). Antibacterial activity, inflammatory response, and coagulation and cytotoxicity effects of silver nanoparticles. Nanomedicine. (In Press). * Corresponding Author.
•Romano E, Raschi AB, Gonzalez AM, Jaime G, Fortuna MA, Hernandez LR, Bach H, Benavente AM. (2011). Phytotoxic activities of (2R)-6-hydroxytremetone. Plant Physiol. Biochem. 49: 671-675.