Position:
Assistant Professor
Division:
Rheumatology
Research Sumary:

My research program focuses on osteoarthritis (OA). My recent work has focused on the detection of early OA and determination of risk factors for OA progression with three major areas of investigations including clinical assessments, biomarker determination and magnetic resonance imaging of joints.In addition to evaluating biomarkers as diagnostic and prognostic markers, understanding the use of biomarkers for evaluation of treatment response is of interest. The development of potential disease-modifying drugs in OA is hindered by the fact that OA is a slowly progressive disease, which implies that clinical trials require long-term and costly follow-up. One of the areas of research interest is the use of biomarkers for assessment of treatment response. I evaluated biomarkers in the glucosamine discontinuation trial and found no treatment effect of glucosamine on biomarkers (Cibere J et al. J Rheumatol 2005;32:896-902). Since biomarkers are preferably measured in serum, such measurements are a reflection of contributions from all joints. To better understand the contribution of a single knee to serum biomarker levels, I developed a study proposal to assess biomarker level before and after total knee arthroplasty.

 

Education:
University of Saskatchewan, MD,
University of British Columbia, Health Care & Epidemiology, PhD,
Recent Publications:

•Kopec JA, Rahman M, Le Petit C, Berthelot JM, Aghajanian J, Sayre EC, Cibere J, Anis AH, Badley EM. Descriptive epidemiology of osteoarthritis in British Columbia, Canada. J Rheumatol 2007;34(2):386-93. Epub 2006 Dec 15.
•Gossec L, Hawker G, Davis AM, Maillefert JF, Lohmander LS, Altman R, Cibere J, Conaghan PG, Hochberg MC, Jordan JM, Katz JN, March L, Mahomed N, Pavelka K, Roos EM, Suarez-Almazor ME, Zanoli G, Dougados M. OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. J Rheumatol 2007;36:1432-5.
•Marra C, Cibere J, Tsuyuki R, Soon J, Esdaile J, Gastonguay L, Oteng  B, Embley P, Colley L, Enenajor G, Kok R. Improving osteoarthritis detection in the community: Pharmacist Identification of New, Diagnostically Confirmed Osteoarthritis. Arthritis Rheum 2007;57(7):1238-1244.
•McWalter EJ*, Cibere J, Nicolaou S, MacIntyre NJ, Nicolaou S, Schulzer M, Wilson DR.  Relationship between varus-valgus alignment and patellar kinematics in individuals with knee osteoarthritis.  J Bone Joint Surg Am 2007;89:2723-31 (*PhD student).
•Cibere J, Thorne A, Bellamy N, Greidanus N, Chalmers A, Mahomed N, Shojania K, Kopec J, Esdaile JM. Reliability of the hip examination in osteoarthritis: Effect of standardization. Arthritis Rheum 2008;59:373-81.
•Hawker, GA, Davis AM, French MR, Cibere J, Jordan JM,  March L, Suarez-Almazor M, Katz JN, Dieppe P. Development and Preliminary Psychometric Testing of a New OA Pain Measure – An OARSI/OMERACT Initiative. Osteoarthritis Cartilage, 2008;16(4):409-414.
•Hawker, GA, Stewart L, French MR, Cibere J, Jordan JM,  March L, Suarez-Almazor M, Gooberman-Hill R.  Understanding the Pain Experience in Hip and Knee Osteoarthritis – An OARSI/OMERACT Initiative. Osteoarthritis Cartilage, 2008;16(4):415-422.
•Kopec JA, Rahman M, Sayre E, Cibere J, Flanagan B, Fines P, Aghajanian J, Anis A, Jordan J, Badley E. Trends in osteoarthritis incidence in British Columbia, Canada, 1996 – 2003. Arthritis Care Res, 2008;59(7):929-34.
•Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec JA, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Differential association of biomarkers with pre-radiographic and radiographic knee osteoarthritis in a population based study. Arthritis Rheum 2009 (in press).
•Cibere J, Zhang H, Thorne A, Wong H, Singer J, Kopec J, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of clinical findings with pre-radiographic and radiographic knee osteoarthritis in a population-based study. Arthritis Rheum 2010;62;(12):1691-8. (FA).
•Grindrod K, Marra C, Colley L, Cibere J, Tsuyuki R, Esdaile J, Gastonguay L, Kopec J. After patients are diagnosed with knee osteoarthritis, what do they do? Arthritis Care Res 2010;62(4):510-515.
•Kopec JA, Sayre EC, Flanagan WM, Fines P, Cibere J, Rahman M, Bansback NJ, Anis AH, Jordan JM, Sobolev B, Aghajanian J, Kang W, Greidanus NV, Garbuz DS, Hawker GA, Badley EM. Development of a population-based microsimulation model of osteoarthritis in Canada. Osteoarthritis Cartilage 2010;18(3):303-311.
•McWalter E*, Wilson D, Cibere J, MacIntyre N. A single measure of patellar kinematics is an inadequate surrogate marker for patterns of three-dimensional kinematics in healthy knees. Knee 2010;17:135-140 (*PhD student).
•Rahman MM, Kopec JA, Sayre EC, Greidanus NV, Aghajanian J, Anis AH, Cibere J, Jordan JM, Badley EM. Effect of Socio-demographic Factors on Surgical Consultations and Hip or Knee Replacements among Patients with Osteoarthritis in British Columbia, Canada J Rheumatol 2010 (Epub ahead of print).
•Ratzlaff C*, Doerfling P, Kopec J, Steininger G, Cibere J, Liang M, McIntyre D, Wilson D. Lifetime trajectory of physical activity according to energy expenditure and joint force. Arthritis Care Res. 2010;62(10):1452-9 (*PhD student).
•Sayre EC*, Jordan JM, Cibere J, Murphy L, Schwartz TA, Helmick CG, Rahman MM, Aghajanian J, Kang W, Badley EM, Kopec JA. Quantifying the association of radiographic osteoarthritis in knee or hip joints with other knees or hips: the Johnston County Osteoarthritis Project. J Rheumatol 2010;37:1260-5. (*Post-doctoral trainee).
•Sayre EC*, Li LC, Kopec JA, Esdaile JM, Bar S, Cibere J. The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis. PLoS One. 2010;3;5:e10470. (*Post-doctoral trainee).
•Cibere J, Sayre EC, Guermazi A, Nicolaou S, Kopec JA, Esdaile JM, Thorne A, Singer J, Wong H. Natural history of cartilage defects and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain. Osteoarthritis Cartilage 2011 (in press). (FA).
•Ip S‡, Sayre EC, Guermazi A, Nicolaou S, Wong H, Thorne A, Singer J, Kopec JA, Esdaile JM, Cibere J. Frequency of bone marrow lesions in knee osteoarthritis and association with pain severity: Results from a population-based study. J Rheumatol 2011 (in press) (‡J. Cibere, summer medical student supervisor). (SA).
•Rahman MM‡, Kopec JA, Sayre EC, Greidanus NV, Aghajanian J, Anis AH, Cibere J, Jordan JM, Badley EM. Effect of socio-demographic factors on surgical consultations and hip or knee replacements among patients with osteoarthritis in British Columbia, Canada. J Rheumatol 2011 (in press). (‡J. Cibere, PhD committee member). (CA).
•Ratzlaff C‡, Steininger G, Doerfling P, Koehoorn M, Cibere J, Liang M, Wilson D, Esdaile J, Kopec J. Influence of Lifetime Hip Joint Force on the Risk of Self-reported Hip Osteoarthritis: A Community-based Cohort Study. Osteoarthritis Cartilage 2011 (in press). (‡J. Cibere, PhD committee member). (CA).